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The map label for this gene is holC [H]

Identifier: 167622894

GI number: 167622894

Start: 1175949

End: 1176452

Strand: Reverse

Name: holC [H]

Synonym: Shal_0954

Alternate gene names: 167622894

Gene position: 1176452-1175949 (Counterclockwise)

Preceding gene: 167622896

Following gene: 167622893

Centisome position: 22.51

GC content: 46.23

Gene sequence:

>504_bases
ATGTTTACGAGCCAATCGTCAAGCCAGTCGCAAGCCCAGTTTTATCTGATGCCAAAGGACGTTAATCGAGCATCCAATGC
GCCTAAAACAGCGTTAGAGCAAGTGTACCTGCTTGCCTGCCAATTGGCCGAGCGAGCGTTTACCGCACATGAGCTCGTTT
ATATTCATTGCCAAGATCAACAGCAAGCTTATGCCGTTGATGAGCTTCTCTGGCAATTTGAACCGCAATCATTTGTGCCC
CACAACCTTAAAGGTGAAGGCCCATTAGGCGGTGCACCGGTAGAAATTGGCTTTGATAGACTTGGCGCCAACAAAAAACG
TCATCTTCTTATTAATCTTGCAGACCAAGTGCCGCAATTTGCGGTAAACTTTGGACAGATTATCGATTTCGTTGCCAACG
ACGATAGCCATAAAGCGATTGCTCGCGATCGCTATCGGCAGTATCGCGCACTTGGAATTGCATTAAGCACCCAAGATATA
GCAACACAACCTATTAATTTTTAG

Upstream 100 bases:

>100_bases
CCGAGCATAAATAAATCGGTGATTATAGGCTGATCTCTGACCTACTTTTAGTGTAAAATCTCCTCTTTCGTCAGCCAAAA
AGCCAAGCCATTAGCAAACT

Downstream 100 bases:

>100_bases
TTTGAGATAAACACGCCCCATGGAAAAAACATATAACCCGCAGTCTATAGAACAGTCTCTTTACCAAAACTGGGAAGAGA
AAGGTTACTTCAAGCCACAC

Product: DNA polymerase III chi subunit HolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MFTSQSSSQSQAQFYLMPKDVNRASNAPKTALEQVYLLACQLAERAFTAHELVYIHCQDQQQAYAVDELLWQFEPQSFVP
HNLKGEGPLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALSTQDI
ATQPINF

Sequences:

>Translated_167_residues
MFTSQSSSQSQAQFYLMPKDVNRASNAPKTALEQVYLLACQLAERAFTAHELVYIHCQDQQQAYAVDELLWQFEPQSFVP
HNLKGEGPLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALSTQDI
ATQPINF
>Mature_167_residues
MFTSQSSSQSQAQFYLMPKDVNRASNAPKTALEQVYLLACQLAERAFTAHELVYIHCQDQQQAYAVDELLWQFEPQSFVP
HNLKGEGPLGGAPVEIGFDRLGANKKRHLLINLADQVPQFAVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALSTQDI
ATQPINF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=146, Percent_Identity=41.7808219178082, Blast_Score=123, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 18767; Mature: 18767

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTSQSSSQSQAQFYLMPKDVNRASNAPKTALEQVYLLACQLAERAFTAHELVYIHCQDQ
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCC
QQAYAVDELLWQFEPQSFVPHNLKGEGPLGGAPVEIGFDRLGANKKRHLLINLADQVPQF
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCCEEEEEEEHHHHHHH
AVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALSTQDIATQPINF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCHHCCCCCCC
>Mature Secondary Structure
MFTSQSSSQSQAQFYLMPKDVNRASNAPKTALEQVYLLACQLAERAFTAHELVYIHCQDQ
CCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCC
QQAYAVDELLWQFEPQSFVPHNLKGEGPLGGAPVEIGFDRLGANKKRHLLINLADQVPQF
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHCCCCCEEEEEEEHHHHHHH
AVNFGQIIDFVANDDSHKAIARDRYRQYRALGIALSTQDIATQPINF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8389364; 8246893; 7610040; 9278503; 2670557; 8505305; 1575709 [H]