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The map label for this gene is sufS [H]

Identifier: 167622759

GI number: 167622759

Start: 1021720

End: 1022931

Strand: Reverse

Name: sufS [H]

Synonym: Shal_0819

Alternate gene names: 167622759

Gene position: 1022931-1021720 (Counterclockwise)

Preceding gene: 167622760

Following gene: 167622758

Centisome position: 19.57

GC content: 50.08

Gene sequence:

>1212_bases
ATGGATCTCTCAACGCTGCGGTCACAGTTCCCAACCCTTGCTCAATCTAACGACGGCTACCCTCTGTGTTACTTAGACAC
GGCAGCAACGAGTCAGAAGCCCCAGCAAGTCATTGATGCCATGAACCACTATTATCATCATGATAATGCCAATGTGCATC
GCGCAGCGCACCAACTATCGGCACGTGCCACCAGCCAGTATGAGGCGGTGCGTGACAAGCTCTGCAAATTTATTAATGCC
TATCGACGTGAAGAGATCATCTTTACTCACGGCACCACTGAATCGATTAATATTGTCGCCAACGGCTTAACGGCTCAAAT
TAAGCAGGGTAGCCTGATTTTAATCGATAGCGCCGCCCACCACGCCAATATAGTGCCTTGGCAAGAGCTCGCAAAGCGCA
CAGGCGCAGTAATTAAGCCTATCCCACTGACGGCAGATTGCCGCCTAGACTTAGCGGCATTTGAAGCGCTATTACAGCAA
AAGCCCGCCATCGTGGCGCTGAGTCATGTATCAAATGCCTTAGGTACACTCAACCCGGTTAACGAGTTAGTTGCCAAAGC
CAAACAAGCTGGCGCTATCACCTTAGTCGATGGCGCTCAGGCTATCGCGCATATGAAGGTTGATGTTCAAACTATCGATT
GTGATTTCTATGTGTTCTCAGGCCACAAGATGTATGGCCCGACAGGCATAGGCGTCTTATATGGTCGCTTCGATATTTTA
GATAACCTAAGTCCCTTGATGACGGGCGGCGAGATGATCAAAACCGTCAGCTTTGAAGCAACCGAGTTTAATCAGCTCCC
CAACAGACTCGAGGCAGGTACGCCACCGATTGCAGAAGTGATCGGCTTAGGCGCCGCAATAGACTTCATCGAGGCACTGC
CAGCTGAACAGGTCCATGCAAAAGAGCGGGAGCTACTCAACTACCTACAAGCATCTCTAAAGAGCCTAGGGGATGTAATA
CTTTATGGCGCCCATCAGGACAATATCGGCGCAGTCGCCTTTAACCTCGCCGATGAGCACCATCAAGATGTGGGCATTTT
ATTAGATCAACAAGGCATAGCGGTGCGCTGCGGCCATCACTGCGCGATGCCCTTGATGCAAAGTTTAGGCTTAAAAGGCT
GCTGCCGCGCCTCGATTGGCGTTTATACTAATAAGGCCGATATCGACCGCTTTATTATGGCGATGGCGTCGGTGAAAGAG
TTATTACTTTAA

Upstream 100 bases:

>100_bases
TTAAAAGCGATGCTTTTAACAGTCTAAACTTGCTTTAGGCGCTCAGATCTTACAAGATCTGAGCGCCTTTTTATTTTTAT
CGATAACCTTGGATCAATTA

Downstream 100 bases:

>100_bases
AAAGAAGGTTCTAGGTTCTAGGAAAGGCTAAGATGGTAGCGGCCGAGTAAAGCAAGAAAAGCAGGAAAATATTAGAGCAA
CCGCAATCAAAGCCCATTGT

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MDLSTLRSQFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
YRREEIIFTHGTTESINIVANGLTAQIKQGSLILIDSAAHHANIVPWQELAKRTGAVIKPIPLTADCRLDLAAFEALLQQ
KPAIVALSHVSNALGTLNPVNELVAKAKQAGAITLVDGAQAIAHMKVDVQTIDCDFYVFSGHKMYGPTGIGVLYGRFDIL
DNLSPLMTGGEMIKTVSFEATEFNQLPNRLEAGTPPIAEVIGLGAAIDFIEALPAEQVHAKERELLNYLQASLKSLGDVI
LYGAHQDNIGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKADIDRFIMAMASVKE
LLL

Sequences:

>Translated_403_residues
MDLSTLRSQFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
YRREEIIFTHGTTESINIVANGLTAQIKQGSLILIDSAAHHANIVPWQELAKRTGAVIKPIPLTADCRLDLAAFEALLQQ
KPAIVALSHVSNALGTLNPVNELVAKAKQAGAITLVDGAQAIAHMKVDVQTIDCDFYVFSGHKMYGPTGIGVLYGRFDIL
DNLSPLMTGGEMIKTVSFEATEFNQLPNRLEAGTPPIAEVIGLGAAIDFIEALPAEQVHAKERELLNYLQASLKSLGDVI
LYGAHQDNIGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKADIDRFIMAMASVKE
LLL
>Mature_403_residues
MDLSTLRSQFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
YRREEIIFTHGTTESINIVANGLTAQIKQGSLILIDSAAHHANIVPWQELAKRTGAVIKPIPLTADCRLDLAAFEALLQQ
KPAIVALSHVSNALGTLNPVNELVAKAKQAGAITLVDGAQAIAHMKVDVQTIDCDFYVFSGHKMYGPTGIGVLYGRFDIL
DNLSPLMTGGEMIKTVSFEATEFNQLPNRLEAGTPPIAEVIGLGAAIDFIEALPAEQVHAKERELLNYLQASLKSLGDVI
LYGAHQDNIGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKADIDRFIMAMASVKE
LLL

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=25.9259259259259, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=47.5247524752475, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=39.0977443609023, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=24.9350649350649, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=228, Percent_Identity=28.5087719298246, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=371, Percent_Identity=22.1024258760108, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=405, Percent_Identity=25.679012345679, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129463, Length=281, Percent_Identity=28.8256227758007, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43787; Mature: 43787

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSTLRSQFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLS
CCHHHHHHHCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHH
ARATSQYEAVRDKLCKFINAYRREEIIFTHGTTESINIVANGLTAQIKQGSLILIDSAAH
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCEEEECCCCEEEEECCCC
HANIVPWQELAKRTGAVIKPIPLTADCRLDLAAFEALLQQKPAIVALSHVSNALGTLNPV
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHCCCHH
NELVAKAKQAGAITLVDGAQAIAHMKVDVQTIDCDFYVFSGHKMYGPTGIGVLYGRFDIL
HHHHHHHHHCCCEEEECCHHHHHEEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHHHHH
DNLSPLMTGGEMIKTVSFEATEFNQLPNRLEAGTPPIAEVIGLGAAIDFIEALPAEQVHA
HCCHHHHCCCHHHHEEECCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
KERELLNYLQASLKSLGDVILYGAHQDNIGAVAFNLADEHHQDVGILLDQQGIAVRCGHH
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCH
CAMPLMQSLGLKGCCRASIGVYTNKADIDRFIMAMASVKELLL
HHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDLSTLRSQFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLS
CCHHHHHHHCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHH
ARATSQYEAVRDKLCKFINAYRREEIIFTHGTTESINIVANGLTAQIKQGSLILIDSAAH
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCEEEECCCCEEEEECCCC
HANIVPWQELAKRTGAVIKPIPLTADCRLDLAAFEALLQQKPAIVALSHVSNALGTLNPV
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHCCCHH
NELVAKAKQAGAITLVDGAQAIAHMKVDVQTIDCDFYVFSGHKMYGPTGIGVLYGRFDIL
HHHHHHHHHCCCEEEECCHHHHHEEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHHHHH
DNLSPLMTGGEMIKTVSFEATEFNQLPNRLEAGTPPIAEVIGLGAAIDFIEALPAEQVHA
HCCHHHHCCCHHHHEEECCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
KERELLNYLQASLKSLGDVILYGAHQDNIGAVAFNLADEHHQDVGILLDQQGIAVRCGHH
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEECCCH
CAMPLMQSLGLKGCCRASIGVYTNKADIDRFIMAMASVKELLL
HHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA