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The map label for this gene is tyrP [H]

Identifier: 167622671

GI number: 167622671

Start: 908138

End: 909337

Strand: Direct

Name: tyrP [H]

Synonym: Shal_0731

Alternate gene names: 167622671

Gene position: 908138-909337 (Clockwise)

Preceding gene: 167622669

Following gene: 167622672

Centisome position: 17.37

GC content: 48.92

Gene sequence:

>1200_bases
GTGAACTCAAAAATACTTGGCTCTATCGCCATTGTTGCCGGAACGGCAATTGGTGGTGGCATGTTGGCATTACCGCTGGC
TACTGCTTCATTAGGTACCATTCCCGCGCTGCTGTTACTTATCACGATTTGGGGTGTATCTATCTATACCTCCCTATTAA
TGCTTGAAATTAACCTACGTGTTGGTGTTGGCTTAAACCTGCATAGCATCACGGGTAAAACCTTAGGTAAGCTAGGTCAG
CTTATTCAAGGCGGCTCATTCTTAAGCCTGTTGTTTGCGCTTACCATGGTCTATCTGATGGGCGGCTCTTCGCTGCTTGA
GTCTAAAATGGAACTGGTTGGCATGAAGATGGACAATCAGTTTGCAGTGCTGCTGTTCACCTTGATTTTCGGTGGTTTTA
TTGCCGTTGGTGTCGGCTGGATTGATAAAGTTTCACGTGTGCTGTTTACCACTATGATCGCGTTGCTGGTCGTTGTCGTC
GCGTACTTGATGCCAGAAGTCGACATGGGCATGATGATGACCAACACTACCGATAGCTTAGTCGACGGGCGTGATCTGAC
TAACCTATGGCTGGCGGCTATTCCAATCGTGTTTACCTCTTTTGGTTTCCATGTCTGTATCGCCACTATCGTGCGTTACT
TAGACGGCGATGCCATGTCGCTGCGTAAGGTATTGATTATCGGTTCAACCATTCCGCTAGTGTGCTATATCCTGTGGCTA
GTGGTGACCTTGGGTACGTTAGGCGGCAAAACGGTTCATGAGTTTGATGGCTCACTGCCACTGCTAGTAACGGCGCTGCA
AGGCGTTGCCGAGTCTTCAATCCTGAAGCACTTTATCGATCTGTTCGCCAACCTTGCGCTGGTGACCTCATTCCTTGGCG
TAACCATGAGTCTGTTTGATTATGTTGCCGAGCTGACTCGCGCGAAAGAGAGCTGGAAGGGACGTGCACAGACTTGGTTA
CTGACTTTTATACCACCGCTATTGTGTGCCCTTTACTATCCAGATGGCTTCTTCAAGGTGCTGGGCTTTGCGGCAATTCC
ACTGGTAGTGATGATTATTTTCCTACCGATAGCGATGGCATTGGGCCTACGTAAGCAAAACTTGGGTGGTTATCAGGTAT
CTGGTGGCAACGCGGCGCTAGGCTTAGCGGCCGTTGCGGGTTTAACTATTATCTTGGCTCAGCTATGGGTCGCACTTTAA

Upstream 100 bases:

>100_bases
GGCTGTTAATGATATTGTTAGCTTGCAAAATCCTCTCCCTCAAAGTCGTTCTAAATCTGACCTATCTAAATAAATAAATA
AAATTTAACAGGACAATTTT

Downstream 100 bases:

>100_bases
TCGTTGCACTTTAATAAATGACAGCATCAGTCTGTAACAACCTTAGCGACTCTTACCTATACAAAGTTATAGCTTTGTAA
GAGATTAATTCAGAAGCTGT

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNSKILGSIAIVAGTAIGGGMLALPLATASLGTIPALLLLITIWGVSIYTSLLMLEINLRVGVGLNLHSITGKTLGKLGQ
LIQGGSFLSLLFALTMVYLMGGSSLLESKMELVGMKMDNQFAVLLFTLIFGGFIAVGVGWIDKVSRVLFTTMIALLVVVV
AYLMPEVDMGMMMTNTTDSLVDGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIDLFANLALVTSFLGVTMSLFDYVAELTRAKESWKGRAQTWL
LTFIPPLLCALYYPDGFFKVLGFAAIPLVVMIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAAVAGLTIILAQLWVAL

Sequences:

>Translated_399_residues
MNSKILGSIAIVAGTAIGGGMLALPLATASLGTIPALLLLITIWGVSIYTSLLMLEINLRVGVGLNLHSITGKTLGKLGQ
LIQGGSFLSLLFALTMVYLMGGSSLLESKMELVGMKMDNQFAVLLFTLIFGGFIAVGVGWIDKVSRVLFTTMIALLVVVV
AYLMPEVDMGMMMTNTTDSLVDGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIDLFANLALVTSFLGVTMSLFDYVAELTRAKESWKGRAQTWL
LTFIPPLLCALYYPDGFFKVLGFAAIPLVVMIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAAVAGLTIILAQLWVAL
>Mature_399_residues
MNSKILGSIAIVAGTAIGGGMLALPLATASLGTIPALLLLITIWGVSIYTSLLMLEINLRVGVGLNLHSITGKTLGKLGQ
LIQGGSFLSLLFALTMVYLMGGSSLLESKMELVGMKMDNQFAVLLFTLIFGGFIAVGVGWIDKVSRVLFTTMIALLVVVV
AYLMPEVDMGMMMTNTTDSLVDGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIDLFANLALVTSFLGVTMSLFDYVAELTRAKESWKGRAQTWL
LTFIPPLLCALYYPDGFFKVLGFAAIPLVVMIIFLPIAMALGLRKQNLGGYQVSGGNAALGLAAVAGLTIILAQLWVAL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=40.6947890818859, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1790145, Length=394, Percent_Identity=29.4416243654822, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789552, Length=372, Percent_Identity=26.8817204301075, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42572; Mature: 42572

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKILGSIAIVAGTAIGGGMLALPLATASLGTIPALLLLITIWGVSIYTSLLMLEINLR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VGVGLNLHSITGKTLGKLGQLIQGGSFLSLLFALTMVYLMGGSSLLESKMELVGMKMDNQ
EECCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
FAVLLFTLIFGGFIAVGVGWIDKVSRVLFTTMIALLVVVVAYLMPEVDMGMMMTNTTDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHH
VDGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHH
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIDLFANLALVTSFLGVTMSLFD
HHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVAELTRAKESWKGRAQTWLLTFIPPLLCALYYPDGFFKVLGFAAIPLVVMIIFLPIAMA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGLRKQNLGGYQVSGGNAALGLAAVAGLTIILAQLWVAL
HCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNSKILGSIAIVAGTAIGGGMLALPLATASLGTIPALLLLITIWGVSIYTSLLMLEINLR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VGVGLNLHSITGKTLGKLGQLIQGGSFLSLLFALTMVYLMGGSSLLESKMELVGMKMDNQ
EECCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCH
FAVLLFTLIFGGFIAVGVGWIDKVSRVLFTTMIALLVVVVAYLMPEVDMGMMMTNTTDSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHH
VDGRDLTNLWLAAIPIVFTSFGFHVCIATIVRYLDGDAMSLRKVLIIGSTIPLVCYILWL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHH
VVTLGTLGGKTVHEFDGSLPLLVTALQGVAESSILKHFIDLFANLALVTSFLGVTMSLFD
HHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVAELTRAKESWKGRAQTWLLTFIPPLLCALYYPDGFFKVLGFAAIPLVVMIIFLPIAMA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGLRKQNLGGYQVSGGNAALGLAAVAGLTIILAQLWVAL
HCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]