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The map label for this gene is serA [H]

Identifier: 167622663

GI number: 167622663

Start: 898752

End: 899981

Strand: Reverse

Name: serA [H]

Synonym: Shal_0723

Alternate gene names: 167622663

Gene position: 899981-898752 (Counterclockwise)

Preceding gene: 167622670

Following gene: 167622662

Centisome position: 17.22

GC content: 48.13

Gene sequence:

>1230_bases
ATGGCGAAACATTCGCTGGACAAGGATAAAATTAAGATCCTGCTGTTGGAAGGCGTCCACCAATCTGCGGTAGATGTATT
TGAACGTGCGGGTTACACCAACATTGAATATCACAAAGCATCACTAGCTGAAGATGAATTACAAACAGCGGTTAAAGATG
CACACTTCATTGGTATCCGCTCCCGTACCCAATTGACTGAAGAAGTATTATCCCAAGCCGACAAACTCATCAGTGTTGGT
TGTTTCTGTATTGGTACCAATCAGGTCAGTCTCGCTGCGGCTGAAAAGCTGGGGATCCCGGTATTCAACGCGCCTTTCTC
AAATACCCGTAGCGTAGCGGAACTGGTATTGGGCGAGATCATCATGCTACTGCGTGGGATCCCACAGCGTAATGCATTGG
CTCACCGTGGTGGTTGGCTAAAGAGTGCTTCGGGAAGTTATGAGGCTCGCGGTAAGACCTTAGGTGTCATCGGCTACGGT
CATATTGGTACTCAGCTTGGTATTCTTGCAGAAACTTTGGGTATGCGCGTTATCTTCTTCGATATCGAAGACAAGCTACC
ACTGGGTAATGCACAGCAAGTGCACTCTCTACAGCAGCTGCTATCACTTGCCGATGTGGTGAGTTTACACGTACCAGAAA
CACCACAGACCAAAGAGATGCTCAGCTATGAAGAGCTGGCCTGTATGCGTAAAGGCAGCATTTTAATTAATGCTTCTCGC
GGTACCGTTGTCGATATTGATGCGCTCGCGGCTTCATTAAAAGAGGAGCACCTTGCTGGCGCCGCCATCGACGTGTTCCC
TATCGAGCCTAAGTCGAATGACGATGAATTTATCAGCCCACTACGCGGCTTAGATAATGTGTTGCTGACGCCACATGTTG
GCGGTAGCACGGCTGAAGCTCAAGAGAATATCGGTATCGAAGTCGCGGGTAAGTTGGCTAAATACTCAGACAATGGCTCG
ACCATGACGGCGGTGAACTTCCCAGAGGTGTCACTTGCTCAACACTCTGGTACGTCGCGCTTACTGCATATTCACCGTAA
CCGCCCTGGAATCTTGATCCAAATTAACTCCGCGTTTGCAGAAAAAGGCATTAACATTGCTGCTCAGTATCTACAAACAA
CCGCTGAAATTGGCTACGTGGTAATGGAAGTCGATTCAGATCAGGCCGAAAATGCATTGGTTGAATTGCAAGCGATTGAA
GGCACGATTAGAACCCGTTTACTTCACTAA

Upstream 100 bases:

>100_bases
GTAGTCTATACCCAAACCACTCCTACAACGTAGAGTTTAGTCGTCTCTGCGGTGGCATTAAGTATACATAATACATATAA
ACTAAAAGGGTACATAAATC

Downstream 100 bases:

>100_bases
AGCTGGGGAAATCTGGGTAAATCAGAGTCATGACTAATTCAGAGTCATGACTAGTCGATTCAGGCTTAGGTTAAGAACAG
AAGATGCGTTGGTTGAGTTG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELQTAVKDAHFIGIRSRTQLTEEVLSQADKLISVG
CFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSYEARGKTLGVIGYG
HIGTQLGILAETLGMRVIFFDIEDKLPLGNAQQVHSLQQLLSLADVVSLHVPETPQTKEMLSYEELACMRKGSILINASR
GTVVDIDALAASLKEEHLAGAAIDVFPIEPKSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDQAENALVELQAIE
GTIRTRLLH

Sequences:

>Translated_409_residues
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELQTAVKDAHFIGIRSRTQLTEEVLSQADKLISVG
CFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSYEARGKTLGVIGYG
HIGTQLGILAETLGMRVIFFDIEDKLPLGNAQQVHSLQQLLSLADVVSLHVPETPQTKEMLSYEELACMRKGSILINASR
GTVVDIDALAASLKEEHLAGAAIDVFPIEPKSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDQAENALVELQAIE
GTIRTRLLH
>Mature_408_residues
AKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELQTAVKDAHFIGIRSRTQLTEEVLSQADKLISVGC
FCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSYEARGKTLGVIGYGH
IGTQLGILAETLGMRVIFFDIEDKLPLGNAQQVHSLQQLLSLADVVSLHVPETPQTKEMLSYEELACMRKGSILINASRG
TVVDIDALAASLKEEHLAGAAIDVFPIEPKSNDDEFISPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGST
MTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDQAENALVELQAIEG
TIRTRLLH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=361, Percent_Identity=31.8559556786704, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=33.9920948616601, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=33.9920948616601, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=33.9920948616601, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=31.1787072243346, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=31.1787072243346, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI6912396, Length=274, Percent_Identity=24.8175182481752, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=67.3965936739659, Blast_Score=576, Evalue=1e-166,
Organism=Escherichia coli, GI1787645, Length=237, Percent_Identity=32.0675105485232, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=28.6852589641434, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788660, Length=310, Percent_Identity=28.3870967741935, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=33.8414634146341, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.792270531401, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.792270531401, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=24.9027237354086, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=26.171875, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=32.890365448505, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571528, Length=297, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=26.0700389105058, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=26.0700389105058, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=26.0700389105058, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=26.0700389105058, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=26.0700389105058, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=23.5880398671096, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44197; Mature: 44066

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELQTAVKDAHFIGIR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHEEEEC
SRTQLTEEVLSQADKLISVGCFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEI
HHHHHHHHHHHHHHHHHEEEEEEEECCCEEEHHHHHCCCCEECCCCCCHHHHHHHHHHHH
IMLLRGIPQRNALAHRGGWLKSASGSYEARGKTLGVIGYGHIGTQLGILAETLGMRVIFF
HHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSLQQLLSLADVVSLHVPETPQTKEMLSYEELACMRKGSILINASR
EECCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEECCC
GTVVDIDALAASLKEEHLAGAAIDVFPIEPKSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFA
HHCCCEEEECCHHEECCCCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCEEEEECHHHH
EKGINIAAQYLQTTAEIGYVVMEVDSDQAENALVELQAIEGTIRTRLLH
HCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHEEEEHHHHHHHHHHCCC
>Mature Secondary Structure 
AKHSLDKDKIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELQTAVKDAHFIGIR
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHHEEEEC
SRTQLTEEVLSQADKLISVGCFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEI
HHHHHHHHHHHHHHHHHEEEEEEEECCCEEEHHHHHCCCCEECCCCCCHHHHHHHHHHHH
IMLLRGIPQRNALAHRGGWLKSASGSYEARGKTLGVIGYGHIGTQLGILAETLGMRVIFF
HHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSLQQLLSLADVVSLHVPETPQTKEMLSYEELACMRKGSILINASR
EECCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCEEEECCC
GTVVDIDALAASLKEEHLAGAAIDVFPIEPKSNDDEFISPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFA
HHCCCEEEECCHHEECCCCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCEEEEECHHHH
EKGINIAAQYLQTTAEIGYVVMEVDSDQAENALVELQAIEGTIRTRLLH
HCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]