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The map label for this gene is dctA [H]

Identifier: 167622293

GI number: 167622293

Start: 414929

End: 416164

Strand: Reverse

Name: dctA [H]

Synonym: Shal_0352

Alternate gene names: 167622293

Gene position: 416164-414929 (Counterclockwise)

Preceding gene: 167622294

Following gene: 167622292

Centisome position: 7.96

GC content: 47.25

Gene sequence:

>1236_bases
ATGGGTATAGCTCACAAATGGAATGACTTTATGTGGCAAAAAATTAAGCCCTATCGCTCCTCTATTATCTTACTTTCGGC
TTTGATGCTAGGAGGACTGATTGGGATCCTCTTTCCAGTGTTTGCCCTTAAGCTAAAGCCCTTGGGCCAGATATTTCTAA
ACTTACTGTTTATGATTATCGTGCCATTAGTGGCGATTAGCGTCACCTCCTCTATCGCCCGTATGACAGACTTAAAAAAA
CTCGGTGTGATCCTAGTGACCATTTTCATGGTCTCTATTGTTATGGCGATTATCCCAACAATAGGAATTATCGGCCTCGC
TTCTATTTACGACCCAGCACAAGGGGTAACCCTAGATCTGCATCAACAAGTGAGCACTGGCTCTGGAAGCATGGATTTTG
TTAACCTGCTGACCACCAACGACTTTGTTGGTTTGCTGTCTAAGTCCAACATTCTGGCACTGATTATCATGTCAGTTATT
TCAGGCATTGCTATTGGGCAGTCAGGAAAGGATGGCGAGAAGGTCTCGGCCATGCTCGATAGCTTAAATACCGTGATCAT
GAAAATCGTCTCTATTTTAATGATCGTTGCACCAGTGGGACTCGGCGCCTACTTTGCATCGACGATGGCCAGCCAAGATA
CCGAACTCTTGAGTACATTTGCCCGTGCTATCGGCCTGTTTTTTATCGCTGCCGCACTCTACTACACCCTTGGTAGCACG
CTATACGCCTGGTTAGGCGGTGGCATTAATGGCATTAAGCAATTTTGGCGCAACGCCATTGAGCCATCAGCGACGGCATT
AGGAACAAGCTCCTCCCTTGCATCACTACCTGTCAATATTCGCGCCGCTAATAAGATGGGCATTAGAGAGGAGATTGCCG
ATATCTGTCTGCCCTTACTGGTAAACCTAAACAAGGGCGGCGCAGCCATGACCACGGCCCTTAAAATTGTGTTTATCTAC
TCGATTCTCGGATTGGATTTTACTGCAGATATCTTTGCGCTAACGGTACTGATTTCTGTCCTCTCAGCCTTTGTGATTGG
CGGCGTGCCAGGCGGGGCTTTTCTTGGCGAGATATTTATCGTCACCACGTTAGGCTTACCGATAGAGGTGATCCCCATCT
TAGTGATTATTGGTGCGGTTACCGACGCCCCAGCAACGGTGATCAACGTGATCCACGACCTCAACGCGACCCAAATAATC
GAACGGATTAACGGTAAGCGTTATGCAAGAAGCTGA

Upstream 100 bases:

>100_bases
TTACCTTGTTCGCCTGTCTATCTACTGTTGACCTATAGTTTATCTATCCCTATTCGCTTTCGTCTGCGAAAAAGCTAATA
CCAACCAGTATAAGCCTTCT

Downstream 100 bases:

>100_bases
GGCTATAGTGACAAACGCCAAAACCTTAGCGAACTAACGACCTCCTTTACCATTGATAGCATATTAAGCAAAAGCATCTT
AATTACAATCAATTAGGCAT

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKK
LGVILVTIFMVSIVMAIIPTIGIIGLASIYDPAQGVTLDLHQQVSTGSGSMDFVNLLTTNDFVGLLSKSNILALIIMSVI
SGIAIGQSGKDGEKVSAMLDSLNTVIMKIVSILMIVAPVGLGAYFASTMASQDTELLSTFARAIGLFFIAAALYYTLGST
LYAWLGGGINGIKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIREEIADICLPLLVNLNKGGAAMTTALKIVFIY
SILGLDFTADIFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQII
ERINGKRYARS

Sequences:

>Translated_411_residues
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKK
LGVILVTIFMVSIVMAIIPTIGIIGLASIYDPAQGVTLDLHQQVSTGSGSMDFVNLLTTNDFVGLLSKSNILALIIMSVI
SGIAIGQSGKDGEKVSAMLDSLNTVIMKIVSILMIVAPVGLGAYFASTMASQDTELLSTFARAIGLFFIAAALYYTLGST
LYAWLGGGINGIKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIREEIADICLPLLVNLNKGGAAMTTALKIVFIY
SILGLDFTADIFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQII
ERINGKRYARS
>Mature_410_residues
GIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMIIVPLVAISVTSSIARMTDLKKL
GVILVTIFMVSIVMAIIPTIGIIGLASIYDPAQGVTLDLHQQVSTGSGSMDFVNLLTTNDFVGLLSKSNILALIIMSVIS
GIAIGQSGKDGEKVSAMLDSLNTVIMKIVSILMIVAPVGLGAYFASTMASQDTELLSTFARAIGLFFIAAALYYTLGSTL
YAWLGGGINGIKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIREEIADICLPLLVNLNKGGAAMTTALKIVFIYS
ILGLDFTADIFALTVLISVLSAFVIGGVPGGAFLGEIFIVTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIE
RINGKRYARS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=29.1512915129151, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=29.1512915129151, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5032093, Length=271, Percent_Identity=29.1512915129151, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=26.7156862745098, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI66773030, Length=307, Percent_Identity=27.3615635179153, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4827012, Length=273, Percent_Identity=27.1062271062271, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI169790839, Length=269, Percent_Identity=26.7657992565056, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40254478, Length=249, Percent_Identity=26.1044176706827, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI194239697, Length=312, Percent_Identity=25.9615384615385, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789947, Length=347, Percent_Identity=27.3775216138329, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790514, Length=380, Percent_Identity=25.2631578947368, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788024, Length=380, Percent_Identity=23.9473684210526, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=392, Percent_Identity=23.9795918367347, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=438, Percent_Identity=23.7442922374429, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983099, Length=438, Percent_Identity=23.7442922374429, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193206505, Length=407, Percent_Identity=24.8157248157248, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996953, Length=272, Percent_Identity=26.4705882352941, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17541374, Length=396, Percent_Identity=25.5050505050505, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193206654, Length=402, Percent_Identity=22.1393034825871, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583025, Length=408, Percent_Identity=24.2647058823529, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137668, Length=408, Percent_Identity=24.2647058823529, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583023, Length=408, Percent_Identity=24.2647058823529, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43575; Mature: 43444

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VPLVAISVTSSIARMTDLKKLGVILVTIFMVSIVMAIIPTIGIIGLASIYDPAQGVTLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
HQQVSTGSGSMDFVNLLTTNDFVGLLSKSNILALIIMSVISGIAIGQSGKDGEKVSAMLD
HHHHCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SLNTVIMKIVSILMIVAPVGLGAYFASTMASQDTELLSTFARAIGLFFIAAALYYTLGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYAWLGGGINGIKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIREEIADICLPLL
HHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHH
VNLNKGGAAMTTALKIVFIYSILGLDFTADIFALTVLISVLSAFVIGGVPGGAFLGEIFI
HCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIERINGKRYARS
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GIAHKWNDFMWQKIKPYRSSIILLSALMLGGLIGILFPVFALKLKPLGQIFLNLLFMII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
VPLVAISVTSSIARMTDLKKLGVILVTIFMVSIVMAIIPTIGIIGLASIYDPAQGVTLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
HQQVSTGSGSMDFVNLLTTNDFVGLLSKSNILALIIMSVISGIAIGQSGKDGEKVSAMLD
HHHHCCCCCCHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SLNTVIMKIVSILMIVAPVGLGAYFASTMASQDTELLSTFARAIGLFFIAAALYYTLGST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYAWLGGGINGIKQFWRNAIEPSATALGTSSSLASLPVNIRAANKMGIREEIADICLPLL
HHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHH
VNLNKGGAAMTTALKIVFIYSILGLDFTADIFALTVLISVLSAFVIGGVPGGAFLGEIFI
HCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VTTLGLPIEVIPILVIIGAVTDAPATVINVIHDLNATQIIERINGKRYARS
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA