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The map label for this gene is fadD [C]

Identifier: 167622004

GI number: 167622004

Start: 72038

End: 73834

Strand: Direct

Name: fadD [C]

Synonym: Shal_0063

Alternate gene names: 167622004

Gene position: 72038-73834 (Clockwise)

Preceding gene: 167622000

Following gene: 167622005

Centisome position: 1.38

GC content: 47.25

Gene sequence:

>1797_bases
ATGTCGCTCGAGCAATATCACGTAGTACGATTAATACAGCAACAAAGCCAAGCACTTGGCGACGCTATTGCGCTCGAAGG
ATTCGAAACAGCAGCGCCATGGCATCAAGTGAGCTGGGCTCAATTTGATACCATCACCTCTAAAATTGCACGGGTGTTGA
TTCAGTTTGGTATTGAATCCCATGACCGCGCAGTGATTTTGTCACAGAACTGTCCACAGTGGACTTGTGCTGATTTTGGC
CTACTAAAGGCTAAAGCCGTTGTTGTACCTATCTATCCAACTAGCACAATTGAACAAGCTACTTACATAGTTAACGATGC
CGAAGCGAAACTTGTCTTCGTCGATGATAAAGATCAGTACGCGATGGCGTGTGATCTCGTTGCTCAGTGTGACAGCTTGA
CTCGAGTTGTGGTATTCGACAAATCTGTTGAGCTACAAGATCAGCAAAATCATTTTTACTTAGACGACCTACTCGAACGT
GAGGTTGACTTAGTCGCAGCAGCAGAGCTTGAAAAGCGCTTAGCGGACTTAAGTTTAGATGACTTATTAACGCTGATTTA
TACTTCAGGTACAACTGGTGACCCTAAAGGGGTGATGCTCGATTACCGTAATTTTGCTTCTATGGTACGTCAGCATGACA
CACTCTTGCCATTTACACCGGGTGATGTGTCATTGGCATTCTTGCCACTGAGTCACGTGTTTGAACGCGGTTGGAGCTTC
TACGTCCTATGTCGTGGCGGCCATAACGTCTACCTGTCTAACCCTATGGCTGTGAAAGAGGCAATTGTACAAGTTCGCCC
GCACACTCTTTGTGTCGTGCCACGCTTCTTAGAAAAAGTGTATAGCGCGGTACAAGACAAGGTCATTAAAGCGCCAGAGA
TGAGACAGAAGATGTTCACTTGGGCGATGTCTGTGGGTCATAAGCAGTCTGAAGTGGGCCAAGGCCGACACAAGGCTTCG
TTGGGCTTAAGTCTGCAGTGGAAACTGGCCGATAAGCTGGTTTTCAGCAAGTTAAAGCAGGTCTTAGGTGGACGCCTTAA
GTTTATGCCTTGCGGCGGTGCGGCACTCGATCCAAATGTCAGTGCTTTCTTCCAAAGCATCGACGTGCCAGTACTGTGTG
GCTATGGCATGACAGAAACCACGGCGACAGCAACCTGCAATACCTTAAGTAATCGCGTGCCAGGTTCTAACGGTAAGGCG
ATACCTGAAGTTGAGATCAAGCTAGGTAAAGACAACGAAATTCTGGTTCGTGGTGATACCGTAATGCGCGGTTACTTCAA
TCGTCCACAAGAAACCGCTGATGCGTTTGAAGATGGTTGGTTGAAAACGGGTGATGCGGGTCGTCTGGATGAAAATGGCA
ACCTGTTTATCACCGACCGCATTAAAGAGTTGATGAAGACCTCAAACGGTAAGTATATCGCTCCGCAACGTGTAGAAGGT
AAAGTGGGGTGTTGCCCATTCATCGAGCAAGTTGCGATTGTTGCCGATGCGCGTAACTATGTGACCGCCTTGATTGTGCC
AGCCTTTGAGTCGTTAGAAGCTTGGGCGAAAGAGAAGGGCGTTCATTACGAAACCCAGCTTGATCTACTACGCAATATTC
GTGTGGTTGAGCTTTTTGAGCAGCGTCTTAAAACTTTGCAAAGCGAGCTCGCTGGCTTTGAGAAGATTAAGAAGTTTACC
TTGTTGCCAGATGCTTTCTCGATGGAAGCGGGTTTAATTACCCCGACCATGAAGCTACGTCGTAAGGTGATTTACAACAA
GTATGCTCGTGAAATCGACAAGATGTACAGCCGCTAA

Upstream 100 bases:

>100_bases
TGAGTTAACAAAAATAGAGCAAAAACTCTTAGTGTTTAGTGCGTCTTCGAGTAAACTTGCGCCAAAGCGGAACACTTGTA
AGCTAAAAGGTAGCCATTTT

Downstream 100 bases:

>100_bases
ACGGGTTTGAAACAGATAAATAAAGGCACGCATTAGCGTGCCTTTTTTATGCCCATGCTTTATTTAAAAGCCCATGGATG
GAAAGCGTTGGTATTTATTT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSLEQYHVVRLIQQQSQALGDAIALEGFETAAPWHQVSWAQFDTITSKIARVLIQFGIESHDRAVILSQNCPQWTCADFG
LLKAKAVVVPIYPTSTIEQATYIVNDAEAKLVFVDDKDQYAMACDLVAQCDSLTRVVVFDKSVELQDQQNHFYLDDLLER
EVDLVAAAELEKRLADLSLDDLLTLIYTSGTTGDPKGVMLDYRNFASMVRQHDTLLPFTPGDVSLAFLPLSHVFERGWSF
YVLCRGGHNVYLSNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDKVIKAPEMRQKMFTWAMSVGHKQSEVGQGRHKAS
LGLSLQWKLADKLVFSKLKQVLGGRLKFMPCGGAALDPNVSAFFQSIDVPVLCGYGMTETTATATCNTLSNRVPGSNGKA
IPEVEIKLGKDNEILVRGDTVMRGYFNRPQETADAFEDGWLKTGDAGRLDENGNLFITDRIKELMKTSNGKYIAPQRVEG
KVGCCPFIEQVAIVADARNYVTALIVPAFESLEAWAKEKGVHYETQLDLLRNIRVVELFEQRLKTLQSELAGFEKIKKFT
LLPDAFSMEAGLITPTMKLRRKVIYNKYAREIDKMYSR

Sequences:

>Translated_598_residues
MSLEQYHVVRLIQQQSQALGDAIALEGFETAAPWHQVSWAQFDTITSKIARVLIQFGIESHDRAVILSQNCPQWTCADFG
LLKAKAVVVPIYPTSTIEQATYIVNDAEAKLVFVDDKDQYAMACDLVAQCDSLTRVVVFDKSVELQDQQNHFYLDDLLER
EVDLVAAAELEKRLADLSLDDLLTLIYTSGTTGDPKGVMLDYRNFASMVRQHDTLLPFTPGDVSLAFLPLSHVFERGWSF
YVLCRGGHNVYLSNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDKVIKAPEMRQKMFTWAMSVGHKQSEVGQGRHKAS
LGLSLQWKLADKLVFSKLKQVLGGRLKFMPCGGAALDPNVSAFFQSIDVPVLCGYGMTETTATATCNTLSNRVPGSNGKA
IPEVEIKLGKDNEILVRGDTVMRGYFNRPQETADAFEDGWLKTGDAGRLDENGNLFITDRIKELMKTSNGKYIAPQRVEG
KVGCCPFIEQVAIVADARNYVTALIVPAFESLEAWAKEKGVHYETQLDLLRNIRVVELFEQRLKTLQSELAGFEKIKKFT
LLPDAFSMEAGLITPTMKLRRKVIYNKYAREIDKMYSR
>Mature_597_residues
SLEQYHVVRLIQQQSQALGDAIALEGFETAAPWHQVSWAQFDTITSKIARVLIQFGIESHDRAVILSQNCPQWTCADFGL
LKAKAVVVPIYPTSTIEQATYIVNDAEAKLVFVDDKDQYAMACDLVAQCDSLTRVVVFDKSVELQDQQNHFYLDDLLERE
VDLVAAAELEKRLADLSLDDLLTLIYTSGTTGDPKGVMLDYRNFASMVRQHDTLLPFTPGDVSLAFLPLSHVFERGWSFY
VLCRGGHNVYLSNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDKVIKAPEMRQKMFTWAMSVGHKQSEVGQGRHKASL
GLSLQWKLADKLVFSKLKQVLGGRLKFMPCGGAALDPNVSAFFQSIDVPVLCGYGMTETTATATCNTLSNRVPGSNGKAI
PEVEIKLGKDNEILVRGDTVMRGYFNRPQETADAFEDGWLKTGDAGRLDENGNLFITDRIKELMKTSNGKYIAPQRVEGK
VGCCPFIEQVAIVADARNYVTALIVPAFESLEAWAKEKGVHYETQLDLLRNIRVVELFEQRLKTLQSELAGFEKIKKFTL
LPDAFSMEAGLITPTMKLRRKVIYNKYAREIDKMYSR

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=622, Percent_Identity=29.903536977492, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI27477105, Length=629, Percent_Identity=28.9348171701113, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI42794760, Length=612, Percent_Identity=28.1045751633987, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI42794758, Length=612, Percent_Identity=28.1045751633987, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI42794756, Length=612, Percent_Identity=28.1045751633987, Blast_Score=224, Evalue=3e-58,
Organism=Homo sapiens, GI57165410, Length=557, Percent_Identity=28.5457809694794, Blast_Score=222, Evalue=9e-58,
Organism=Homo sapiens, GI57165412, Length=557, Percent_Identity=28.5457809694794, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI83745141, Length=602, Percent_Identity=26.7441860465116, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI12669909, Length=602, Percent_Identity=25.5813953488372, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4758332, Length=602, Percent_Identity=25.5813953488372, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI42794754, Length=605, Percent_Identity=25.4545454545455, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI42794752, Length=605, Percent_Identity=25.4545454545455, Blast_Score=186, Evalue=8e-47,
Organism=Escherichia coli, GI1788107, Length=470, Percent_Identity=24.2553191489362, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI145693145, Length=163, Percent_Identity=33.1288343558282, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788595, Length=355, Percent_Identity=24.5070422535211, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556552, Length=560, Percent_Identity=30.1785714285714, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17510401, Length=587, Percent_Identity=29.6422487223169, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17553312, Length=640, Percent_Identity=24.84375, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17541856, Length=602, Percent_Identity=28.9036544850498, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI25147511, Length=601, Percent_Identity=25.7903494176373, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17564090, Length=539, Percent_Identity=28.0148423005566, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI193204819, Length=625, Percent_Identity=27.2, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17559526, Length=496, Percent_Identity=25.6048387096774, Blast_Score=125, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=483, Percent_Identity=23.6024844720497, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17531443, Length=460, Percent_Identity=23.4782608695652, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=169, Percent_Identity=31.3609467455621, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=211, Percent_Identity=29.3838862559242, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=365, Percent_Identity=23.5616438356164, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560140, Length=132, Percent_Identity=32.5757575757576, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320852, Length=644, Percent_Identity=24.6894409937888, Blast_Score=178, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324893, Length=624, Percent_Identity=25.8012820512821, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323903, Length=613, Percent_Identity=24.3066884176183, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322182, Length=616, Percent_Identity=25.1623376623377, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319699, Length=160, Percent_Identity=30.625, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366413, Length=598, Percent_Identity=29.5986622073579, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24666501, Length=597, Percent_Identity=29.6482412060301, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24666497, Length=597, Percent_Identity=29.6482412060301, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI17933690, Length=635, Percent_Identity=27.7165354330709, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI19921316, Length=624, Percent_Identity=27.4038461538462, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI62471679, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI62471683, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI62471685, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24586636, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI62471681, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI62471687, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24586634, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI22026970, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI62471689, Length=610, Percent_Identity=25.7377049180328, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=25.5278310940499, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130357, Length=140, Percent_Identity=33.5714285714286, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI18859661, Length=214, Percent_Identity=29.4392523364486, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 67019; Mature: 66888

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEQYHVVRLIQQQSQALGDAIALEGFETAAPWHQVSWAQFDTITSKIARVLIQFGIES
CCCHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCC
HDRAVILSQNCPQWTCADFGLLKAKAVVVPIYPTSTIEQATYIVNDAEAKLVFVDDKDQY
CCCEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHEEEEECCCEEEEEEECCCCH
AMACDLVAQCDSLTRVVVFDKSVELQDQQNHFYLDDLLEREVDLVAAAELEKRLADLSLD
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLLTLIYTSGTTGDPKGVMLDYRNFASMVRQHDTLLPFTPGDVSLAFLPLSHVFERGWSF
HHHHHHEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHCCCEE
YVLCRGGHNVYLSNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDKVIKAPEMRQKMFT
EEEEECCCEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WAMSVGHKQSEVGQGRHKASLGLSLQWKLADKLVFSKLKQVLGGRLKFMPCGGAALDPNV
HHHHCCCCHHHHCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
SAFFQSIDVPVLCGYGMTETTATATCNTLSNRVPGSNGKAIPEVEIKLGKDNEILVRGDT
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCC
VMRGYFNRPQETADAFEDGWLKTGDAGRLDENGNLFITDRIKELMKTSNGKYIAPQRVEG
EEEHHCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCC
KVGCCPFIEQVAIVADARNYVTALIVPAFESLEAWAKEKGVHYETQLDLLRNIRVVELFE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHH
QRLKTLQSELAGFEKIKKFTLLPDAFSMEAGLITPTMKLRRKVIYNKYAREIDKMYSR
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLEQYHVVRLIQQQSQALGDAIALEGFETAAPWHQVSWAQFDTITSKIARVLIQFGIES
CCHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCC
HDRAVILSQNCPQWTCADFGLLKAKAVVVPIYPTSTIEQATYIVNDAEAKLVFVDDKDQY
CCCEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHEEEEECCCEEEEEEECCCCH
AMACDLVAQCDSLTRVVVFDKSVELQDQQNHFYLDDLLEREVDLVAAAELEKRLADLSLD
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHH
DLLTLIYTSGTTGDPKGVMLDYRNFASMVRQHDTLLPFTPGDVSLAFLPLSHVFERGWSF
HHHHHHEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHCCCEE
YVLCRGGHNVYLSNPMAVKEAIVQVRPHTLCVVPRFLEKVYSAVQDKVIKAPEMRQKMFT
EEEEECCCEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
WAMSVGHKQSEVGQGRHKASLGLSLQWKLADKLVFSKLKQVLGGRLKFMPCGGAALDPNV
HHHHCCCCHHHHCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
SAFFQSIDVPVLCGYGMTETTATATCNTLSNRVPGSNGKAIPEVEIKLGKDNEILVRGDT
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCC
VMRGYFNRPQETADAFEDGWLKTGDAGRLDENGNLFITDRIKELMKTSNGKYIAPQRVEG
EEEHHCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHHCCCCCEECCCCCCC
KVGCCPFIEQVAIVADARNYVTALIVPAFESLEAWAKEKGVHYETQLDLLRNIRVVELFE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHH
QRLKTLQSELAGFEKIKKFTLLPDAFSMEAGLITPTMKLRRKVIYNKYAREIDKMYSR
HHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]