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The map label for this gene is dnaA [H]

Identifier: 167621942

GI number: 167621942

Start: 81

End: 1466

Strand: Direct

Name: dnaA [H]

Synonym: Shal_0001

Alternate gene names: 167621942

Gene position: 81-1466 (Clockwise)

Preceding gene: NA

Following gene: 167621943

Centisome position: 0.0

GC content: 42.21

Gene sequence:

>1386_bases
GTGGCGGTTTCACTTTGGCAACAATGTATCGCAAGGCTGCAAGATGAGCTCTCTGCTCAGCAATTCAGTATGTGGATAAG
ACCGTTACAAGTAGAAATGGAAGGCGATACTCTCGTCATCTATGCGCCTAACCGTTTTGTGTTGGATTGGGTTAGGGATA
AATACCTAAATATCATCAACCAATTTTTTACTGAACAAATGGGTAGCGATGCGCCAAATTTGCGTTTCGATATTGGTAGT
CGTCCATCGGCTAGGCCTATTGTTCAGGCTACTGCAGCAATAAGAACTAGCAGACCAGTTAGTAGAGAAGTTGTTAAGCC
TTCTTTTAATACTCCACATGCTGACCCTATTGCTAATGCTAATCACCGTAGCAATATTAATCCCACTTATCAGTTTGACA
ACTTCGTCGAAGGTAAATCAAATCAGTTGGGTAAGGCCGCTGCTATGCAGGTGGCTGAAAATCCAGGCGGTGCCTATAAC
CCACTCTTCCTTTATGGTGGCACTGGTTTAGGTAAGACTCACCTTTTGCATGCTGTTGGCAATGGTATTATTAAGAATAA
TCCTAATGCCAAAGTGGTTTATATGCATTCTGAGCGCTTTGTGCAGGATATGGTTAAGGCATTGCAAAATAACGCGATTG
AAGAGTTTAAGCGTTATTATCGCAGTGTTGATGCACTATTTATCGATGATATTCAATTTTTTGCCAATAAAGACAGATCG
CAAGAAGAGTTTTTTCATACCTTTAATGCACTATTAGAGGGGAATCATCAGATCATCTTAACTTCAGACAAGTATCCAAA
AGAGATCGATGGTGTTGAGGATCGTCTTAAGTCTCGCTTTGGCTGGGGACTAACGGTAGCTATTGAGCCGCCAGAGTTAG
AAACTCGTGTGGCGATCTTGATGCGTAAGGCACAAGAGAGCGGTATTAACTTACCTGATGAAGTGGCTTTCTTTATTGCT
AAGCGTTTACGTTCAAACGTACGTGAGCTAGAAGGCGCATTGAACCGAGTTATTGCTAACGCCAACTTTACCGGTCGTCC
TATCACTATCGATTTTGTTCGGGAAGCATTGCGCGATCTGCTTGCTCTACAAGAGAAGCTAGTCACTATCGATAATATCC
AAAAGACGGTAGCGGAATACTACAAGATTAAGATGGCTGATATGTTGTCTAAGCGTCGTTCACGCAGTGTCGCCAGACCT
AGGCAGGTGGCTATGGCGTTATCAAAAGAATTAACTAACCAGAGTTTGCCAGAAATTGGTGATGCATTTGGTGGTCGTGA
CCATACAACTGTTTTACACGCATGTCGTAAAATTGCGCAGTTGCGTGAAGAAAGTCATGACATTAAAGAAGATTATGCTA
ACTTGATAAGAACCTTATCTTCTTAA

Upstream 100 bases:

>100_bases
TAGTTGATCTATCTGGGGATAAATATATTTAAAGGATAGCGATCAGCGTGATCTCACTATAGAATAGGCCTCTTTTGTAT
GATTTTTGGGGATAACTACA

Downstream 100 bases:

>100_bases
TATCTGGGATATTGAACCAATGAAATTTTCAATTGATAGGGACGCCTTATTAAAACCGCTTCAACTAGTTAGTGGCGCGG
TTGAAAGACGTCATAACTTG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAVSLWQQCIARLQDELSAQQFSMWIRPLQVEMEGDTLVIYAPNRFVLDWVRDKYLNIINQFFTEQMGSDAPNLRFDIGS
RPSARPIVQATAAIRTSRPVSREVVKPSFNTPHADPIANANHRSNINPTYQFDNFVEGKSNQLGKAAAMQVAENPGGAYN
PLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRS
QEEFFHTFNALLEGNHQIILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIA
KRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARP
RQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS

Sequences:

>Translated_461_residues
MAVSLWQQCIARLQDELSAQQFSMWIRPLQVEMEGDTLVIYAPNRFVLDWVRDKYLNIINQFFTEQMGSDAPNLRFDIGS
RPSARPIVQATAAIRTSRPVSREVVKPSFNTPHADPIANANHRSNINPTYQFDNFVEGKSNQLGKAAAMQVAENPGGAYN
PLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRS
QEEFFHTFNALLEGNHQIILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIA
KRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARP
RQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
>Mature_460_residues
AVSLWQQCIARLQDELSAQQFSMWIRPLQVEMEGDTLVIYAPNRFVLDWVRDKYLNIINQFFTEQMGSDAPNLRFDIGSR
PSARPIVQATAAIRTSRPVSREVVKPSFNTPHADPIANANHRSNINPTYQFDNFVEGKSNQLGKAAAMQVAENPGGAYNP
LFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRSQ
EEFFHTFNALLEGNHQIILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIAK
RLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPR
QVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=468, Percent_Identity=78.8461538461538, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=230, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52282; Mature: 52151

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSLWQQCIARLQDELSAQQFSMWIRPLQVEMEGDTLVIYAPNRFVLDWVRDKYLNIIN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
QFFTEQMGSDAPNLRFDIGSRPSARPIVQATAAIRTSRPVSREVVKPSFNTPHADPIANA
HHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCC
NHRSNINPTYQFDNFVEGKSNQLGKAAAMQVAENPGGAYNPLFLYGGTGLGKTHLLHAVG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHC
NGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRS
CCCEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QEEFFHTFNALLEGNHQIILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAIL
HHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHH
MRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHH
LALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHH
DAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVSLWQQCIARLQDELSAQQFSMWIRPLQVEMEGDTLVIYAPNRFVLDWVRDKYLNIIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
QFFTEQMGSDAPNLRFDIGSRPSARPIVQATAAIRTSRPVSREVVKPSFNTPHADPIANA
HHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCC
NHRSNINPTYQFDNFVEGKSNQLGKAAAMQVAENPGGAYNPLFLYGGTGLGKTHLLHAVG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHC
NGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRS
CCCEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QEEFFHTFNALLEGNHQIILTSDKYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAIL
HHHHHHHHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHH
MRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHH
LALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHH
DAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA