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Identifier: 16752297

GI number: 16752297

Start: 201

End: 1199

Strand: Direct

Name: Not Available

Synonym: CP0001

Alternate gene names: 16752297

Gene position: 201-1199 (Clockwise)

Preceding gene: NA

Following gene: 16752300

Centisome position: 0.02

GC content: 39.24

Gene sequence:

>999_bases
ATGAGTTCTTTAACACTAAGTAGACGTCCTAGAAGAAACCGAAAGACAGCAGCTATAAGAGATTTGTTGGCCGAAACTCA
CTTAAGCCCAAAAGATCTCATAGCACCATTCTTTGTGAAGTATGGAAATAACATAAAGGAAGAGATCCCGAGTCTTCCTG
GAGTGTTCCGATGGAGTTTGGATTTGCTATTAAAGGAAATAGAGCGTTTGTGTACCTACGGGTTACGAGCTGTAATGCTG
TTTCCCATTATTCCTGATGATCTTAAAGATGCTTACGGTTCTTACTCCTCAAATCCTAAAAACATCTTATGTCATAGCAT
TCATGAAATAAAAAACGCATTTCCTCACCTATGTCTGATTAGTGATATAGCTTTAGATCCTTATACGACACACGGTCATG
ATGGGATTTTCCTTAATGGAGAGGTCCTTAATGATGAAAGTGTTAGAATTTTTGGAAATATTGCAACTTTACATGCTGAA
ATGGGAGCGGATATCGTAGCTCCGAGTGATATGATGGATGGAAGGATTGGCTACATTCGCTCTAAGTTAGACCAGTCTGG
CTACTCAAAGACCTCTATAATGTCTTATAGTGTAAAGTACGCTTCTTGTTTGTATTCTCCTTTTCGTGATGCGCTGAGTT
CTCACGTAACTTCAGGAGATAAAAAACAGTATCAGATGAACCCTAAAAACGTATTAGAGGCATTGCTTGAATCTTCTTTA
GACGAGGAGGAGGGAGCAGATATCTTAATGGTGAAGCCTGCAGGACTCTATCTTGATGTGATCTATCGGATTCGACAAAA
TACCTGTTTGCCTCTAGCTGCGTATCAGGTCAGTGGGGAATACGCTATGATCTTATCAGCCTTTCAACAAGGTTGGTTAG
ATAAAGAAACACTATTTCATGAGTCTTTGATAGCAATCAAGAGAGCTGGCGCAGATATGATTATTAGTTACTCCGCTCCT
TTTATTTTGGAATTACTGCATCAGGGATTTGAATTTTAA

Upstream 100 bases:

>100_bases
TTAAACAGTTTCCACACCCCCTAAAGAAGAAGAGAATATTATGTATAAATATAACAATATATATTTAGGACCTGTGGAAA
CTGTTGAAAGGATCTGAGAA

Downstream 100 bases:

>100_bases
GTTCTTTGAAGAACAAAAAATCAATCTTGATGGGGAGTTAGGATCCCTGATTCCTTGGCATACTCTATTAAGGATTCCTT
GACTATGGTAAGCATTTCTG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSLDLLLKEIERLCTYGLRAVML
FPIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLISDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAE
MGADIVAPSDMMDGRIGYIRSKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSL
DEEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFHESLIAIKRAGADMIISYSAP
FILELLHQGFEF

Sequences:

>Translated_332_residues
MSSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSLDLLLKEIERLCTYGLRAVML
FPIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLISDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAE
MGADIVAPSDMMDGRIGYIRSKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSL
DEEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFHESLIAIKRAGADMIISYSAP
FILELLHQGFEF
>Mature_331_residues
SSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSLDLLLKEIERLCTYGLRAVMLF
PIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLISDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAEM
GADIVAPSDMMDGRIGYIRSKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSLD
EEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFHESLIAIKRAGADMIISYSAPF
ILELLHQGFEF

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=39.9350649350649, Blast_Score=218, Evalue=5e-57,
Organism=Escherichia coli, GI87081728, Length=323, Percent_Identity=44.8916408668731, Blast_Score=254, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6321398, Length=316, Percent_Identity=38.9240506329114, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21358291, Length=323, Percent_Identity=34.0557275541796, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM2_CHLPN (Q9Z7G1)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   E86583
- PIR:   F72040
- RefSeq:   NP_224940.1
- RefSeq:   NP_300800.1
- RefSeq:   NP_444554.1
- RefSeq:   NP_877044.1
- ProteinModelPortal:   Q9Z7G1
- SMR:   Q9Z7G1
- GeneID:   1467451
- GeneID:   895528
- GeneID:   919514
- GeneID:   963624
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0001
- KEGG:   cpn:CPn0744
- KEGG:   cpt:CpB0772
- TIGR:   CP_0001
- HOGENOM:   HBG285270
- OMA:   WINVGIL
- PhylomeDB:   Q9Z7G1
- ProtClustDB:   PRK09283
- BioCyc:   CPNE115711:CP_0001-MONOMER
- BioCyc:   CPNE115713:CPN0744-MONOMER
- BioCyc:   CPNE138677:CPJ0744-MONOMER
- BioCyc:   CPNE182082:CPB0772-MONOMER
- BRENDA:   4.2.1.24
- InterPro:   IPR001731
- InterPro:   IPR013785
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR11458
- PIRSF:   PIRSF001415
- PRINTS:   PR00144

Pfam domain/function: PF00490 ALAD

EC number: =4.2.1.24

Molecular weight: Translated: 37280; Mature: 37149

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: ACT_SITE 199-199 ACT_SITE 252-252 BINDING 209-209 BINDING 221-221 BINDING 278-278 BINDING 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
DLLLKEIERLCTYGLRAVMLFPIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEHH
SDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAEMGADIVAPSDMMDGRIGYIR
HHHCCCCCCCCCCCCEEECCEEECCCCEEEEEHHHHHHHHHCCCEECCCHHHCCHHHHHH
SKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHCC
DEEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFH
CHHCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHH
ESLIAIKRAGADMIISYSAPFILELLHQGFEF
HHHHHHHHCCCCEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
DLLLKEIERLCTYGLRAVMLFPIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLI
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEHH
SDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAEMGADIVAPSDMMDGRIGYIR
HHHCCCCCCCCCCCCEEECCEEECCCCEEEEEHHHHHHHHHCCCEECCCHHHCCHHHHHH
SKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHCC
DEEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFH
CHHCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHH
ESLIAIKRAGADMIISYSAPFILELLHQGFEF
HHHHHHHHCCCCEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362