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The map label for this gene is thrB [H]

Identifier: 167040923

GI number: 167040923

Start: 2329283

End: 2330209

Strand: Reverse

Name: thrB [H]

Synonym: Teth514_2309

Alternate gene names: 167040923

Gene position: 2330209-2329283 (Counterclockwise)

Preceding gene: 167040924

Following gene: 167040922

Centisome position: 94.83

GC content: 35.71

Gene sequence:

>927_bases
ATGGAGAGTGACATGGTAAAGGTAAAAGTTCCAGCCTCTTCTGCAAACTTAGGGCCCGGTTTTGACTCTATAGGAGTAGC
ACTAAATTTGTATACAGAAATTTCTATGGGATTTATAGAAGAAGGGCTCTTGATAGAGGTTTCAGGAGAGGACTATAAAG
AAATTGAAACAACTGAGAATAATCTTGTCTATAAAGCGGCTAAAAAAGTTTTTGAAAAAACTGAGACACAATATGAAGGA
TTAAAAATAGAAATAAGAAATGGTATTCCTGTGGGTGCTGGTCTTGGAAGTAGTGCGGCAGCAATAATTGGAGGAATGTT
GGCAGCAAATGAACTTGCAGGGGGTATTTTAACACATAAAGAAATTTTAGACCTTGCGGCTTCTATGGAAGGGCATGCCG
ATAATGTAGCTCCTGCTCTAAATGGAGGACTGAATGTAACGGTTTTTGACGGTAATACTACTTATTATGTAAAAAAAGAA
TTAGAAGAAGAATTAAAATTTATTGCCTTTACTCCCAAAAAACTTTTAAAAACAGAGATTGCAAGAAATATATTGCCCCA
AAAAATAGATTTTAAAGATGCTGTATTCAATACAGGTAGGTCTTCTCTTTTAACAGCAGCTTTGTTTAGTGGAAGGTACG
ATTTGTTAAAGATTGCTTCTCAAGATATGCTACATCAAAAATATCGCTCTAAACTTATACCTGAAATGTATGCCTGTTTT
GAAAAAGCTTTAGAAGCAGGTGCTTATTCTGTTTTTTTAAGTGGAGCAGGCCCCACAATTATGGCTATTTGTCCAGAGGA
AAAGGTAAAAAGAGTAGTTTATGAAGTAAGCAAGGTATATATTGACCGGGGAATAGACTATAGAGTGTATAAACTTCACT
GCGAAAATAACGGTGCCCAAGTTTTGAAGGCTTCTCTATCAATATAG

Upstream 100 bases:

>100_bases
TTGACGGGAAATGGATTAAAAGATCCAGATACTGCTGTTAAATTAGGTGGCGAGATAAAAACGATAGAGGCGAATCTAAA
AGCATTGGAGGAAGTTTTAT

Downstream 100 bases:

>100_bases
AGGAGCTTTTTTTAATTATAATATTTATTTTTTTAAAATAAGTGTATGATAGGTTTAAAAAATAATAGAAAATGTTTCTT
TACTTATTACTGGGATGAAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MESDMVKVKVPASSANLGPGFDSIGVALNLYTEISMGFIEEGLLIEVSGEDYKEIETTENNLVYKAAKKVFEKTETQYEG
LKIEIRNGIPVGAGLGSSAAAIIGGMLAANELAGGILTHKEILDLAASMEGHADNVAPALNGGLNVTVFDGNTTYYVKKE
LEEELKFIAFTPKKLLKTEIARNILPQKIDFKDAVFNTGRSSLLTAALFSGRYDLLKIASQDMLHQKYRSKLIPEMYACF
EKALEAGAYSVFLSGAGPTIMAICPEEKVKRVVYEVSKVYIDRGIDYRVYKLHCENNGAQVLKASLSI

Sequences:

>Translated_308_residues
MESDMVKVKVPASSANLGPGFDSIGVALNLYTEISMGFIEEGLLIEVSGEDYKEIETTENNLVYKAAKKVFEKTETQYEG
LKIEIRNGIPVGAGLGSSAAAIIGGMLAANELAGGILTHKEILDLAASMEGHADNVAPALNGGLNVTVFDGNTTYYVKKE
LEEELKFIAFTPKKLLKTEIARNILPQKIDFKDAVFNTGRSSLLTAALFSGRYDLLKIASQDMLHQKYRSKLIPEMYACF
EKALEAGAYSVFLSGAGPTIMAICPEEKVKRVVYEVSKVYIDRGIDYRVYKLHCENNGAQVLKASLSI
>Mature_308_residues
MESDMVKVKVPASSANLGPGFDSIGVALNLYTEISMGFIEEGLLIEVSGEDYKEIETTENNLVYKAAKKVFEKTETQYEG
LKIEIRNGIPVGAGLGSSAAAIIGGMLAANELAGGILTHKEILDLAASMEGHADNVAPALNGGLNVTVFDGNTTYYVKKE
LEEELKFIAFTPKKLLKTEIARNILPQKIDFKDAVFNTGRSSLLTAALFSGRYDLLKIASQDMLHQKYRSKLIPEMYACF
EKALEAGAYSVFLSGAGPTIMAICPEEKVKRVVYEVSKVYIDRGIDYRVYKLHCENNGAQVLKASLSI

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=316, Percent_Identity=27.5316455696203, Blast_Score=116, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=351, Percent_Identity=29.9145299145299, Blast_Score=139, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33582; Mature: 33582

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESDMVKVKVPASSANLGPGFDSIGVALNLYTEISMGFIEEGLLIEVSGEDYKEIETTEN
CCCCEEEEEECCCCCCCCCCCHHHHHEEEHHHHHHHHHHCCCCEEEECCCCHHHHHCCCC
NLVYKAAKKVFEKTETQYEGLKIEIRNGIPVGAGLGSSAAAIIGGMLAANELAGGILTHK
CCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EILDLAASMEGHADNVAPALNGGLNVTVFDGNTTYYVKKELEEELKFIAFTPKKLLKTEI
HHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCEEEEEHHHHHHHHHEEEECHHHHHHHHH
ARNILPQKIDFKDAVFNTGRSSLLTAALFSGRYDLLKIASQDMLHQKYRSKLIPEMYACF
HHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKALEAGAYSVFLSGAGPTIMAICPEEKVKRVVYEVSKVYIDRGIDYRVYKLHCENNGAQ
HHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCE
VLKASLSI
EHHEECCC
>Mature Secondary Structure
MESDMVKVKVPASSANLGPGFDSIGVALNLYTEISMGFIEEGLLIEVSGEDYKEIETTEN
CCCCEEEEEECCCCCCCCCCCHHHHHEEEHHHHHHHHHHCCCCEEEECCCCHHHHHCCCC
NLVYKAAKKVFEKTETQYEGLKIEIRNGIPVGAGLGSSAAAIIGGMLAANELAGGILTHK
CCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EILDLAASMEGHADNVAPALNGGLNVTVFDGNTTYYVKKELEEELKFIAFTPKKLLKTEI
HHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCEEEEEHHHHHHHHHEEEECHHHHHHHHH
ARNILPQKIDFKDAVFNTGRSSLLTAALFSGRYDLLKIASQDMLHQKYRSKLIPEMYACF
HHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKALEAGAYSVFLSGAGPTIMAICPEEKVKRVVYEVSKVYIDRGIDYRVYKLHCENNGAQ
HHHHCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCE
VLKASLSI
EHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]