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The map label for this gene is serA [H]

Identifier: 167040920

GI number: 167040920

Start: 2320608

End: 2322203

Strand: Reverse

Name: serA [H]

Synonym: Teth514_2306

Alternate gene names: 167040920

Gene position: 2322203-2320608 (Counterclockwise)

Preceding gene: 167040921

Following gene: 167040918

Centisome position: 94.5

GC content: 36.28

Gene sequence:

>1596_bases
TTGAAGATAATTGTCACAGAGAAAATATCAGAAAATGGCATTGAATATCTAAAAAAACACGCTGACGTAGACGTGAAAAC
TAATATTTCAAGAGATGAGCTTTTAGAAATTATTAAAGATTATGACGCTATTATTGTTAGAAGTGCTACAAAAGTAGATA
GAGAACTTATCGAAAAAGGTGAAAGATTAAAAGTCATAGGTCGTGCGGGAAATGGTGTTGACAACATTGATGTGTCATCA
GCTACTGAAAAAGGAATCCTTGTTGTAAATACTCCTGCTGGAAATATCGTTGCTGCCGCGGAATTGACCATTGGTCTTAT
GCTGGCTATAGCCAGAAATATACCGCAGGCATATCATGCTGGTCTTAATGGAGACTTTAGAAGGGATAAATTCAAAGGCG
TTGAATTGAACGGAAAAACTGTCGGCGTAATAGGATTAGGAAGAATTGGTTCTCTTGTGGCGTCTAGACTTGCAGCATTT
AATATGAGAGTAATTGCATATGATCCCTATATGCCAGATGAACGTTTTGAAAAATACGGTGTGGAAAAAGTTACTTTAGA
TGAATTGCTTCAGCAATCAGACTTTATAACAATTCACCTCCCAAAAACGGAAGAGACCAAAAAAATGCTCAGCGAAAAAG
AGTTCAAAAAAATGAAAAAGGGAGTTAGAATAGTAAATGCCGCACGAGGAGGCATCATTGATGAAAAAGCCCTTTACAAT
GCTATTAAAGAGGGCATTGTAGCGGCAGCAGGGTTAGACGTTCTTGAAGTAGAACCTAAATATAATGTAGAACGACAAGA
TTTTCACAATCCTCTTCTTGAACTGCCAAATGTTGTTTTTACTCTTCACATTGGAGCTTCAACTTATGAAGCGCAAGAAA
ACATAGGCATATCCATTGCTCAAGAAGTAATCTCGGCTTTAAACGGTAATCTCTACGGAAATATAGTAAATTTACCCGGG
GTAAAATCCGACGAATTTTCACAGCTTAAACCTTATATGAAATTGGCTGAAGCCATGGGAGCACTTTATTATCAAATAAA
TGATACTCCTGTTAGATTAGTTGAAGTGATATATAGAGGAGAGATTTCTAGAACTAATACAGATATTGTTACTCTCTATG
CTCTTAAAGGCTTTTTAAAGCCTGTATTGGAGGAGGATGTAAGTGTTGTAAATGCTAGATTAAGGGCAAAAGAAATGGGA
ATAGAAGTTGTAGAGGGGAAAATCGAAGAAATAAACCACTATTCAAGCCTTATTATTCTCAAAATTACAGATACCAATGG
CAAAACGACACAATTTGCAGGAACCACATATGGAGAAGAAATAAGAATTGTAGAGTATATGGGACATAAAGTAAATTTTG
AACCTACGGAGTACATGCTATTTGTCAAGAATAAAGACGTGCCAGGGGTTATAGGTCACATAGGAAATGTATTAGGAGAC
TTTGGCATAAACATTTCCACTATGCAAGTAAGCCCCAATAAAAATGATGGAACAGCATTAATGATTGTAAGTACGGACAG
AGAAATTCCTGATGAAGCGGTAGAGTCTCTAAATAAATTAAATAGCATAATAAAAGCAAGAGCGGTAAGGGGTTAA

Upstream 100 bases:

>100_bases
ATTATAAGAATAGGTCACATGGGTTATGTGACTGAAGAAATGCTTACTGAAACTCTTGAGGCGTTGAAAGACGCAATAAA
GGGGTAAGGAGGGATATAAT

Downstream 100 bases:

>100_bases
TATAAAAAAAGGAGCAAGTTTTTTCTTGCTCCTTTAAATATTATAAGGTTAAATATTATAAGGTGTTCTTTTTCTCCCTT
CAAAATAATAAAGAGTATTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKIIVTEKISENGIEYLKKHADVDVKTNISRDELLEIIKDYDAIIVRSATKVDRELIEKGERLKVIGRAGNGVDNIDVSS
ATEKGILVVNTPAGNIVAAAELTIGLMLAIARNIPQAYHAGLNGDFRRDKFKGVELNGKTVGVIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKYGVEKVTLDELLQQSDFITIHLPKTEETKKMLSEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAAGLDVLEVEPKYNVERQDFHNPLLELPNVVFTLHIGASTYEAQENIGISIAQEVISALNGNLYGNIVNLPG
VKSDEFSQLKPYMKLAEAMGALYYQINDTPVRLVEVIYRGEISRTNTDIVTLYALKGFLKPVLEEDVSVVNARLRAKEMG
IEVVEGKIEEINHYSSLIILKITDTNGKTTQFAGTTYGEEIRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMIVSTDREIPDEAVESLNKLNSIIKARAVRG

Sequences:

>Translated_531_residues
MKIIVTEKISENGIEYLKKHADVDVKTNISRDELLEIIKDYDAIIVRSATKVDRELIEKGERLKVIGRAGNGVDNIDVSS
ATEKGILVVNTPAGNIVAAAELTIGLMLAIARNIPQAYHAGLNGDFRRDKFKGVELNGKTVGVIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKYGVEKVTLDELLQQSDFITIHLPKTEETKKMLSEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAAGLDVLEVEPKYNVERQDFHNPLLELPNVVFTLHIGASTYEAQENIGISIAQEVISALNGNLYGNIVNLPG
VKSDEFSQLKPYMKLAEAMGALYYQINDTPVRLVEVIYRGEISRTNTDIVTLYALKGFLKPVLEEDVSVVNARLRAKEMG
IEVVEGKIEEINHYSSLIILKITDTNGKTTQFAGTTYGEEIRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMIVSTDREIPDEAVESLNKLNSIIKARAVRG
>Mature_531_residues
MKIIVTEKISENGIEYLKKHADVDVKTNISRDELLEIIKDYDAIIVRSATKVDRELIEKGERLKVIGRAGNGVDNIDVSS
ATEKGILVVNTPAGNIVAAAELTIGLMLAIARNIPQAYHAGLNGDFRRDKFKGVELNGKTVGVIGLGRIGSLVASRLAAF
NMRVIAYDPYMPDERFEKYGVEKVTLDELLQQSDFITIHLPKTEETKKMLSEKEFKKMKKGVRIVNAARGGIIDEKALYN
AIKEGIVAAAGLDVLEVEPKYNVERQDFHNPLLELPNVVFTLHIGASTYEAQENIGISIAQEVISALNGNLYGNIVNLPG
VKSDEFSQLKPYMKLAEAMGALYYQINDTPVRLVEVIYRGEISRTNTDIVTLYALKGFLKPVLEEDVSVVNARLRAKEMG
IEVVEGKIEEINHYSSLIILKITDTNGKTTQFAGTTYGEEIRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
FGINISTMQVSPNKNDGTALMIVSTDREIPDEAVESLNKLNSIIKARAVRG

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=379, Percent_Identity=42.2163588390501, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI61743967, Length=304, Percent_Identity=34.2105263157895, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=287, Percent_Identity=35.5400696864112, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4557499, Length=287, Percent_Identity=35.5400696864112, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4557497, Length=304, Percent_Identity=34.2105263157895, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=36, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=31.6614420062696, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1789279, Length=324, Percent_Identity=32.4074074074074, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87082289, Length=323, Percent_Identity=30.9597523219814, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=37.3015873015873, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788660, Length=231, Percent_Identity=32.034632034632, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=314, Percent_Identity=41.4012738853503, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147481, Length=288, Percent_Identity=31.9444444444444, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=341, Percent_Identity=36.3636363636364, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320925, Length=341, Percent_Identity=35.4838709677419, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324055, Length=301, Percent_Identity=31.5614617940199, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=282, Percent_Identity=28.3687943262411, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=28.8659793814433, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=157, Percent_Identity=33.7579617834395, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=323, Percent_Identity=40.5572755417957, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24646446, Length=290, Percent_Identity=36.2068965517241, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646448, Length=290, Percent_Identity=36.2068965517241, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646452, Length=290, Percent_Identity=36.2068965517241, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646450, Length=290, Percent_Identity=36.2068965517241, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI62472511, Length=314, Percent_Identity=34.7133757961783, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=30.7958477508651, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571528, Length=319, Percent_Identity=34.7962382445141, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=31.3291139240506, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574284, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45551003, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45552429, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24585514, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574282, Length=323, Percent_Identity=31.8885448916409, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58667; Mature: 58667

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVTEKISENGIEYLKKHADVDVKTNISRDELLEIIKDYDAIIVRSATKVDRELIEKG
CEEEEECCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHCCC
ERLKVIGRAGNGVDNIDVSSATEKGILVVNTPAGNIVAAAELTIGLMLAIARNIPQAYHA
CEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHC
GLNGDFRRDKFKGVELNGKTVGVIGLGRIGSLVASRLAAFNMRVIAYDPYMPDERFEKYG
CCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHC
VEKVTLDELLQQSDFITIHLPKTEETKKMLSEKEFKKMKKGVRIVNAARGGIIDEKALYN
CCEECHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
AIKEGIVAAAGLDVLEVEPKYNVERQDFHNPLLELPNVVFTLHIGASTYEAQENIGISIA
HHHHHHHHHCCCCEEEECCCCCCCHHHHCCHHHHCCCEEEEEEECCCCHHHHHCCCHHHH
QEVISALNGNLYGNIVNLPGVKSDEFSQLKPYMKLAEAMGALYYQINDTPVRLVEVIYRG
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHC
EISRTNTDIVTLYALKGFLKPVLEEDVSVVNARLRAKEMGIEVVEGKIEEINHYSSLIIL
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCCEEEEE
KITDTNGKTTQFAGTTYGEEIRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
EEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
FGINISTMQVSPNKNDGTALMIVSTDREIPDEAVESLNKLNSIIKARAVRG
CCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIIVTEKISENGIEYLKKHADVDVKTNISRDELLEIIKDYDAIIVRSATKVDRELIEKG
CEEEEECCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCEEEECHHHHHHHHHCCC
ERLKVIGRAGNGVDNIDVSSATEKGILVVNTPAGNIVAAAELTIGLMLAIARNIPQAYHA
CEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHC
GLNGDFRRDKFKGVELNGKTVGVIGLGRIGSLVASRLAAFNMRVIAYDPYMPDERFEKYG
CCCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHC
VEKVTLDELLQQSDFITIHLPKTEETKKMLSEKEFKKMKKGVRIVNAARGGIIDEKALYN
CCEECHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCCHHHHHH
AIKEGIVAAAGLDVLEVEPKYNVERQDFHNPLLELPNVVFTLHIGASTYEAQENIGISIA
HHHHHHHHHCCCCEEEECCCCCCCHHHHCCHHHHCCCEEEEEEECCCCHHHHHCCCHHHH
QEVISALNGNLYGNIVNLPGVKSDEFSQLKPYMKLAEAMGALYYQINDTPVRLVEVIYRG
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHC
EISRTNTDIVTLYALKGFLKPVLEEDVSVVNARLRAKEMGIEVVEGKIEEINHYSSLIIL
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCCEEEEE
KITDTNGKTTQFAGTTYGEEIRIVEYMGHKVNFEPTEYMLFVKNKDVPGVIGHIGNVLGD
EEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
FGINISTMQVSPNKNDGTALMIVSTDREIPDEAVESLNKLNSIIKARAVRG
CCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]