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The map label for this gene is pyrG [H]

Identifier: 167040918

GI number: 167040918

Start: 2317780

End: 2319381

Strand: Reverse

Name: pyrG [H]

Synonym: Teth514_2304

Alternate gene names: 167040918

Gene position: 2319381-2317780 (Counterclockwise)

Preceding gene: 167040920

Following gene: 167040917

Centisome position: 94.39

GC content: 35.89

Gene sequence:

>1602_bases
ATGACAAAATATATTTTTGTAACAGGAGGAGTTGTATCCTCTCTTGGGAAAGGCATAACTGCTGCATCATTGGGAAGGCT
TTTAAAAAGCCGCGGCATATCAGTTGCAGTACAAAAATTTGACCCTTATATAAACATAGACCCTGGTACAATGAGTCCAT
ACCAACATGGTGAAGTTTTTGTCACTGAGGATGGTGCAGAGACAGATTTAGACCTCGGCCATTATGAAAGATTTATAGAC
ATTAATCTTACAAAAAATAGCAATGTAACAGCAGGTAAAGTGTACTGGTCTGTCATTACAAAAGAGAGAAAAGGGGATTA
TCTTGGTATCACAGTACAAGTAATACCTCATATAACAAACGAAATTAAAGAAAGAGTATACAGAGTTGCAAAAGAAAAGA
ATGTGGATGTAGTAATAACCGAAATTGGTGGTACAGTAGGAGACATAGAAAGTCTTCCTTTCCTTGAAGCTATAAGACAA
GTAGCAATTGAACAAGGAAGAGAAAATGTAATGTTTATTCATGTCACATTAGTACCTCATCTTGGAAAGACAGGGGAATT
AAAAACAAAACCTACTCAACATAGCGTAAAAGAACTGCGCTCTATAGGTATTCAACCGGATATGATTGTATGTAGAACAG
AACTTTCTTTAACACAGGACTTAAAAGAAAAGATTGCTCTTTTTTGCAATGTAAGTGTAGAAGCTGTTATAGAAAATAGG
GATGTAGAATCAATTTATGAAGTACCATTAGAATTAGAAAGACAAAAAGTAGATGAATATGTGTTAAAAAGATTAAATTT
GCCACTTGGCCAATCGGATTTAAAAGAGTGGAGAGAATATGTAGAAAGAGAAAAAAATCCCATAAAAGAGGTAGAAGTAG
CGTTAGTAGGTAAGTATGTAGACCTTCATGATGCATATATAAGTGTGGTAGAGGCATTAAAACACGCAGGGGTTTATCAT
AGCGCTGCTGTGAATATAAGATGGGTAAATGCAGAGCATGTGAATGATGAGACAGTAGAAACACTTTTAAAAGGTGCAGA
CGGCATATTAGTGCCTGGAGGATTTGGCGATAGAGGCATTGAAGGGAAGATAAGAGCTATACAATATGCAAGGGAAAACA
AAATCCCTTATCTTGGATTGTGTCTTGGTATGCAATGCGCTGTAATAGAATTTGCAAGAAATGTAGCAGGACTAAAAGGA
GCTAATTCTACAGAATTTGACCCAAATACTTCCTATCCTGTAATAGACCTTATGCCTGAACAAAAAGATATAGATGAAAA
AGGCGGTACCATGAGATTAGGAGTGTATCCTTGCAAAGTGATTGAAGGTACAAAAGCTTATCAGGCTTATCAAGACGAAT
TAGTATATGAAAGGCATAGACATAGGTACGAATTTAATAACCAATACAGAGAACTTTTAACTTCAAAAGGCCTTGTACTT
TCAGGACTTTCTCCTGATGAACGGTTGGTGGAAATAATAGAATTAAAGGACCATCCTTATTTTGTAGCATCCCAGTTTCA
TCCAGAGTTTAAATCAAGGCCTTTAAAACCTCATCCTCTGTTTAGGGATTTTATAGGGGCTATATTAAAGATTAAAGGGT
AA

Upstream 100 bases:

>100_bases
GATACGAGTCTCTATTTTTCCAAAATAGAGATTTTTTTATGGGTTAAAAATACTTAAAAATTAATCATAAAAAACGATAA
TACACTTAAGAGGTGAGATA

Downstream 100 bases:

>100_bases
TTTTTGTGGGGGTAAGATGATTGTACCCCATAATTTATATGTGAAATAGGTATTTAAACAATTAGCTAATAAATCCGAAA
ATATATATATAAAAGTAAAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKSRGISVAVQKFDPYINIDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFID
INLTKNSNVTAGKVYWSVITKERKGDYLGITVQVIPHITNEIKERVYRVAKEKNVDVVITEIGGTVGDIESLPFLEAIRQ
VAIEQGRENVMFIHVTLVPHLGKTGELKTKPTQHSVKELRSIGIQPDMIVCRTELSLTQDLKEKIALFCNVSVEAVIENR
DVESIYEVPLELERQKVDEYVLKRLNLPLGQSDLKEWREYVEREKNPIKEVEVALVGKYVDLHDAYISVVEALKHAGVYH
SAAVNIRWVNAEHVNDETVETLLKGADGILVPGGFGDRGIEGKIRAIQYARENKIPYLGLCLGMQCAVIEFARNVAGLKG
ANSTEFDPNTSYPVIDLMPEQKDIDEKGGTMRLGVYPCKVIEGTKAYQAYQDELVYERHRHRYEFNNQYRELLTSKGLVL
SGLSPDERLVEIIELKDHPYFVASQFHPEFKSRPLKPHPLFRDFIGAILKIKG

Sequences:

>Translated_533_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKSRGISVAVQKFDPYINIDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFID
INLTKNSNVTAGKVYWSVITKERKGDYLGITVQVIPHITNEIKERVYRVAKEKNVDVVITEIGGTVGDIESLPFLEAIRQ
VAIEQGRENVMFIHVTLVPHLGKTGELKTKPTQHSVKELRSIGIQPDMIVCRTELSLTQDLKEKIALFCNVSVEAVIENR
DVESIYEVPLELERQKVDEYVLKRLNLPLGQSDLKEWREYVEREKNPIKEVEVALVGKYVDLHDAYISVVEALKHAGVYH
SAAVNIRWVNAEHVNDETVETLLKGADGILVPGGFGDRGIEGKIRAIQYARENKIPYLGLCLGMQCAVIEFARNVAGLKG
ANSTEFDPNTSYPVIDLMPEQKDIDEKGGTMRLGVYPCKVIEGTKAYQAYQDELVYERHRHRYEFNNQYRELLTSKGLVL
SGLSPDERLVEIIELKDHPYFVASQFHPEFKSRPLKPHPLFRDFIGAILKIKG
>Mature_532_residues
TKYIFVTGGVVSSLGKGITAASLGRLLKSRGISVAVQKFDPYINIDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIDI
NLTKNSNVTAGKVYWSVITKERKGDYLGITVQVIPHITNEIKERVYRVAKEKNVDVVITEIGGTVGDIESLPFLEAIRQV
AIEQGRENVMFIHVTLVPHLGKTGELKTKPTQHSVKELRSIGIQPDMIVCRTELSLTQDLKEKIALFCNVSVEAVIENRD
VESIYEVPLELERQKVDEYVLKRLNLPLGQSDLKEWREYVEREKNPIKEVEVALVGKYVDLHDAYISVVEALKHAGVYHS
AAVNIRWVNAEHVNDETVETLLKGADGILVPGGFGDRGIEGKIRAIQYARENKIPYLGLCLGMQCAVIEFARNVAGLKGA
NSTEFDPNTSYPVIDLMPEQKDIDEKGGTMRLGVYPCKVIEGTKAYQAYQDELVYERHRHRYEFNNQYRELLTSKGLVLS
GLSPDERLVEIIELKDHPYFVASQFHPEFKSRPLKPHPLFRDFIGAILKIKG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=542, Percent_Identity=51.1070110701107, Blast_Score=523, Evalue=1e-148,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=49.5479204339964, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=49.5479204339964, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=49.5479204339964, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1789142, Length=536, Percent_Identity=56.3432835820896, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI25148299, Length=595, Percent_Identity=41.8487394957983, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=557, Percent_Identity=46.1400359066427, Blast_Score=483, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322563, Length=559, Percent_Identity=46.8694096601073, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24664469, Length=546, Percent_Identity=50.7326007326007, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=49.0872210953347, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59979; Mature: 59847

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSLGKGITAASLGRLLKSRGISVAVQKFDPYINIDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIDINLTKNSNVTAGKVYWSVITKERKGDYLGITVQVIPHITN
EECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHEEEEEEEHHCCCCEEEEEEEEHHHHHH
EIKERVYRVAKEKNVDVVITEIGGTVGDIESLPFLEAIRQVAIEQGRENVMFIHVTLVPH
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECC
LGKTGELKTKPTQHSVKELRSIGIQPDMIVCRTELSLTQDLKEKIALFCNVSVEAVIENR
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCC
DVESIYEVPLELERQKVDEYVLKRLNLPLGQSDLKEWREYVEREKNPIKEVEVALVGKYV
CHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLHDAYISVVEALKHAGVYHSAAVNIRWVNAEHVNDETVETLLKGADGILVPGGFGDRGI
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIRAIQYARENKIPYLGLCLGMQCAVIEFARNVAGLKGANSTEFDPNTSYPVIDLMPE
CCHHHHEEEHHHCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QKDIDEKGGTMRLGVYPCKVIEGTKAYQAYQDELVYERHRHRYEFNNQYRELLTSKGLVL
CCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
SGLSPDERLVEIIELKDHPYFVASQFHPEFKSRPLKPHPLFRDFIGAILKIKG
ECCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHEEECC
>Mature Secondary Structure 
TKYIFVTGGVVSSLGKGITAASLGRLLKSRGISVAVQKFDPYINIDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIDINLTKNSNVTAGKVYWSVITKERKGDYLGITVQVIPHITN
EECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHEEEEEEEHHCCCCEEEEEEEEHHHHHH
EIKERVYRVAKEKNVDVVITEIGGTVGDIESLPFLEAIRQVAIEQGRENVMFIHVTLVPH
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECC
LGKTGELKTKPTQHSVKELRSIGIQPDMIVCRTELSLTQDLKEKIALFCNVSVEAVIENR
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCC
DVESIYEVPLELERQKVDEYVLKRLNLPLGQSDLKEWREYVEREKNPIKEVEVALVGKYV
CHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DLHDAYISVVEALKHAGVYHSAAVNIRWVNAEHVNDETVETLLKGADGILVPGGFGDRGI
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIRAIQYARENKIPYLGLCLGMQCAVIEFARNVAGLKGANSTEFDPNTSYPVIDLMPE
CCHHHHEEEHHHCCCCEEEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
QKDIDEKGGTMRLGVYPCKVIEGTKAYQAYQDELVYERHRHRYEFNNQYRELLTSKGLVL
CCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
SGLSPDERLVEIIELKDHPYFVASQFHPEFKSRPLKPHPLFRDFIGAILKIKG
ECCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]