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The map label for this gene is ndk

Identifier: 167040848

GI number: 167040848

Start: 2230524

End: 2230931

Strand: Direct

Name: ndk

Synonym: Teth514_2228

Alternate gene names: 167040848

Gene position: 2230524-2230931 (Clockwise)

Preceding gene: 167040847

Following gene: 167040849

Centisome position: 90.77

GC content: 39.22

Gene sequence:

>408_bases
ATGGAGACCACCCTTGCTATAGTAAAACCCGACGGTGTCAAGAGAGGGCTTATAGGAGAAATATTAAAAAGATATGAAAA
CAAAGGTTTAAGGCTTAAAGCGGCAAAAGTAATAACTCCAACAATTGAGCTTTTAGAAAAGCACTACGAGGAACACAAAG
GCAAGCCTTACTACAAACCTTTAATACAGTACATGTCCTCAGGTCCTGTCTTTGCAATGGTACTAGAAGGAGAAAACGCC
GTAAAAATAGTAAGACTTTTAAATGGTGCCACAAAAGTAGAAGAAGCACTTCCTGGGACGATAAGAGGTGATTTTGCCAT
AAGCACCACTTTTAACATCATACACGGCTCAGATAGTATTGAATCTGCAAAGAGAGAAATAGCACTGTGGTTTCCTGAAT
TAGCATGA

Upstream 100 bases:

>100_bases
AAGAAGCTTATATAGCCGCCGGAATCTTTTCATTAATATGCGCCTTTACTTCTCTTGTGAGAAATGATGTTAAATTAATA
AAAGGAAAGGATTGATTTAA

Downstream 100 bases:

>100_bases
ATATTTTTGTGGACAGGGCATAAACTCTAATAGAGAAAACTATTGGAGGTATACCTTATGCCCAAAATAACAGTAGAAAG
TAAAAATAACCAGTATGGAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
METTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVITPTIELLEKHYEEHKGKPYYKPLIQYMSSGPVFAMVLEGENA
VKIVRLLNGATKVEEALPGTIRGDFAISTTFNIIHGSDSIESAKREIALWFPELA

Sequences:

>Translated_135_residues
METTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVITPTIELLEKHYEEHKGKPYYKPLIQYMSSGPVFAMVLEGENA
VKIVRLLNGATKVEEALPGTIRGDFAISTTFNIIHGSDSIESAKREIALWFPELA
>Mature_135_residues
METTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVITPTIELLEKHYEEHKGKPYYKPLIQYMSSGPVFAMVLEGENA
VKIVRLLNGATKVEEALPGTIRGDFAISTTFNIIHGSDSIESAKREIALWFPELA

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=55.3846153846154, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI38045913, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI66392203, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=53.7313432835821, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=50.7692307692308, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=37.8571428571429, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI148839372, Length=136, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=31.6546762589928, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=30.5970149253731, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=30.5970149253731, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI4505413, Length=138, Percent_Identity=34.0579710144928, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=47.3684210526316, Blast_Score=130, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=52.2727272727273, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17507605, Length=92, Percent_Identity=44.5652173913043, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=50.7692307692308, Blast_Score=144, Evalue=6e-36,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=55.3030303030303, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18860097, Length=137, Percent_Identity=39.4160583941606, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_THEP3 (B0KAQ8)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665528.1
- ProteinModelPortal:   B0KAQ8
- SMR:   B0KAQ8
- GeneID:   5874803
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1547
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   TPSE340099:TETH39_1547-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15024; Mature: 15024

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVITPTIELLEKHYEEHKGKPYYKP
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
LIQYMSSGPVFAMVLEGENAVKIVRLLNGATKVEEALPGTIRGDFAISTTFNIIHGSDSI
HHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCHH
ESAKREIALWFPELA
HHHHHHEEEECCCCC
>Mature Secondary Structure
METTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVITPTIELLEKHYEEHKGKPYYKP
CCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
LIQYMSSGPVFAMVLEGENAVKIVRLLNGATKVEEALPGTIRGDFAISTTFNIIHGSDSI
HHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCHH
ESAKREIALWFPELA
HHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA