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The map label for this gene is mdeA [H]

Identifier: 167040507

GI number: 167040507

Start: 1890333

End: 1891358

Strand: Reverse

Name: mdeA [H]

Synonym: Teth514_1876

Alternate gene names: 167040507

Gene position: 1891358-1890333 (Counterclockwise)

Preceding gene: 167040508

Following gene: 167040503

Centisome position: 76.97

GC content: 31.19

Gene sequence:

>1026_bases
ATGGGAGTAAATAAAAACTATCGGTTTGACACAAAAGTAATTCATGGAAATGAGTTTAAGAAAAACCCTGAAAATGCTTT
GAATCCTCCAATTTTCCAGACGACTACTTTTGTTTTTGATGACCTTGAACATGTTGAAAAGGTGATGTCTTTTCAATCTC
AAGACTATGTTTATACAAGAGGTAATAATCCTACATTAAGATTATTTGAAAACAGATTAGCGGAGTTAGAATATGGTAAA
GGGGCAGTAGCTTTTTCTTCCGGGATGGCCGCTATTAGTTCAGTTTTATTTTCTCTTTTAAAACCCAAAGATAATGTAAT
AATTCATAAGACTCTTTATGGTTCAAGTTATAACGTGGTGACAAATATTTTGCCTAAATATGGAGTAAATTATAAAATAG
TGGATCTTACAGATATAAGCGAATTAGAAAAAAGTATAGATGACTCTACAAAAGTTGTGTATTTTGAGACCCCTTCTAAT
CCAAATTTATCTATTATAGATATTGAAGAGGTTGCAAGGGTATGTCATAAAAAAGATATTAAAATTGTTGTTGATAATAC
TTTTGCTACCCCCTATTTTCAAAATCCTCTTCTATTGGGAGCCGATGTAGTTGTTCATAGTGCTACTAAATATATAGGAG
GTCACGGTGATGCACTTGGGGGAGTTGCAGTTTCCCAAGATGAAAAGTATATACATTATTTAAAATTTGATTATATGTGT
GAATTTGGTGGAGTAATGAGTCCTTTCAATGCTTGGTTGATGTTGAGAGGTATAAAAACTTTAGGTATAAGAATGAGACA
ACATGAAAAAAATGCAATAGAGGTAGCAAATTTTTTAAATTCGCATCCTAAAGTAAAAAACGTTATGTATCCTGGTCTTA
AAAGTTTTAAAGGTTATGAAATAGCGAAAAAACAAATGAGAGGATTCGGAGCTATCATAAGTTTTGAAATAGAGGGAGGA
ACCAAAAATTTAGAGAAGTTTATTGTCAATTCTCAAATTAAATCTCCAAAGATTTTCAAATTATAA

Upstream 100 bases:

>100_bases
TATTGCAATAAATTTATAAGCCGGGTATGCTATAATTAAAGAGCATACCCGGTATGTCATTGATATGGAGTATTGTGATT
AAATTATAGGAGGAAGTCCT

Downstream 100 bases:

>100_bases
TGGCATTTTTTAAGTGCATAAAAGTATTTTTTCTCAAATTATCACAGCCTGATTAAAAATTTTTTTCACTTTTTAAGAGC
ATAACCGCCAAAATATGTTA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MGVNKNYRFDTKVIHGNEFKKNPENALNPPIFQTTTFVFDDLEHVEKVMSFQSQDYVYTRGNNPTLRLFENRLAELEYGK
GAVAFSSGMAAISSVLFSLLKPKDNVIIHKTLYGSSYNVVTNILPKYGVNYKIVDLTDISELEKSIDDSTKVVYFETPSN
PNLSIIDIEEVARVCHKKDIKIVVDNTFATPYFQNPLLLGADVVVHSATKYIGGHGDALGGVAVSQDEKYIHYLKFDYMC
EFGGVMSPFNAWLMLRGIKTLGIRMRQHEKNAIEVANFLNSHPKVKNVMYPGLKSFKGYEIAKKQMRGFGAIISFEIEGG
TKNLEKFIVNSQIKSPKIFKL

Sequences:

>Translated_341_residues
MGVNKNYRFDTKVIHGNEFKKNPENALNPPIFQTTTFVFDDLEHVEKVMSFQSQDYVYTRGNNPTLRLFENRLAELEYGK
GAVAFSSGMAAISSVLFSLLKPKDNVIIHKTLYGSSYNVVTNILPKYGVNYKIVDLTDISELEKSIDDSTKVVYFETPSN
PNLSIIDIEEVARVCHKKDIKIVVDNTFATPYFQNPLLLGADVVVHSATKYIGGHGDALGGVAVSQDEKYIHYLKFDYMC
EFGGVMSPFNAWLMLRGIKTLGIRMRQHEKNAIEVANFLNSHPKVKNVMYPGLKSFKGYEIAKKQMRGFGAIISFEIEGG
TKNLEKFIVNSQIKSPKIFKL
>Mature_340_residues
GVNKNYRFDTKVIHGNEFKKNPENALNPPIFQTTTFVFDDLEHVEKVMSFQSQDYVYTRGNNPTLRLFENRLAELEYGKG
AVAFSSGMAAISSVLFSLLKPKDNVIIHKTLYGSSYNVVTNILPKYGVNYKIVDLTDISELEKSIDDSTKVVYFETPSNP
NLSIIDIEEVARVCHKKDIKIVVDNTFATPYFQNPLLLGADVVVHSATKYIGGHGDALGGVAVSQDEKYIHYLKFDYMCE
FGGVMSPFNAWLMLRGIKTLGIRMRQHEKNAIEVANFLNSHPKVKNVMYPGLKSFKGYEIAKKQMRGFGAIISFEIEGGT
KNLEKFIVNSQIKSPKIFKL

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=38.4615384615385, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI299473759, Length=324, Percent_Identity=34.5679012345679, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI25453487, Length=323, Percent_Identity=30.9597523219814, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1790375, Length=300, Percent_Identity=35.6666666666667, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789383, Length=321, Percent_Identity=28.9719626168224, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=324, Percent_Identity=40.1234567901235, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17538055, Length=324, Percent_Identity=38.8888888888889, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71980708, Length=303, Percent_Identity=34.983498349835, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319307, Length=342, Percent_Identity=36.5497076023392, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323333, Length=355, Percent_Identity=34.3661971830986, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321170, Length=319, Percent_Identity=28.2131661442006, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321254, Length=331, Percent_Identity=31.1178247734139, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=322, Percent_Identity=32.2981366459627, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922554, Length=336, Percent_Identity=37.202380952381, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 38452; Mature: 38321

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVNKNYRFDTKVIHGNEFKKNPENALNPPIFQTTTFVFDDLEHVEKVMSFQSQDYVYTR
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEC
GNNPTLRLFENRLAELEYGKGAVAFSSGMAAISSVLFSLLKPKDNVIIHKTLYGSSYNVV
CCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
TNILPKYGVNYKIVDLTDISELEKSIDDSTKVVYFETPSNPNLSIIDIEEVARVCHKKDI
HHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHHHHHCCCCC
KIVVDNTFATPYFQNPLLLGADVVVHSATKYIGGHGDALGGVAVSQDEKYIHYLKFDYMC
EEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEEHHH
EFGGVMSPFNAWLMLRGIKTLGIRMRQHEKNAIEVANFLNSHPKVKNVMYPGLKSFKGYE
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCCCCCCCCCHH
IAKKQMRGFGAIISFEIEGGTKNLEKFIVNSQIKSPKIFKL
HHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GVNKNYRFDTKVIHGNEFKKNPENALNPPIFQTTTFVFDDLEHVEKVMSFQSQDYVYTR
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEC
GNNPTLRLFENRLAELEYGKGAVAFSSGMAAISSVLFSLLKPKDNVIIHKTLYGSSYNVV
CCCCEEHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
TNILPKYGVNYKIVDLTDISELEKSIDDSTKVVYFETPSNPNLSIIDIEEVARVCHKKDI
HHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHHHHHCCCCC
KIVVDNTFATPYFQNPLLLGADVVVHSATKYIGGHGDALGGVAVSQDEKYIHYLKFDYMC
EEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEEHHH
EFGGVMSPFNAWLMLRGIKTLGIRMRQHEKNAIEVANFLNSHPKVKNVMYPGLKSFKGYE
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHCCCCCCCCCCHH
IAKKQMRGFGAIISFEIEGGTKNLEKFIVNSQIKSPKIFKL
HHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]