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The map label for this gene is trpE [H]

Identifier: 167040500

GI number: 167040500

Start: 1883557

End: 1884984

Strand: Reverse

Name: trpE [H]

Synonym: Teth514_1869

Alternate gene names: 167040500

Gene position: 1884984-1883557 (Counterclockwise)

Preceding gene: 167040501

Following gene: 167040499

Centisome position: 76.71

GC content: 34.59

Gene sequence:

>1428_bases
GTGGTAAACATTTCTAAAGAAGATTTTTGCGAACACAAAAAAAGAGGATATGTCTTCCCAGTCTATGCAGAAATAAACGG
AGATGAACTGACACCAATAAACATTTTTTATAGTCTTAAAGGCAAAAACAAATTTTTACTGGAAAGTGCAAATGGAGGCA
CTAACTGGGGCAGGTACTCCTTTATAGGAAAAGACCCTTATTTATCAATTTTAAGTTATGGAAAAAGGATAAAACTTATA
GGTGAAAGTGAAGAAGAAAAAGAAGGCTTAATTCTTGATGAAATAAGAGATATTATGAATTTTAAGTACAATTCCTTAGG
GCTTGATATCCCGTTTGTAGGTGGGGCTATAGGTTATGCTTCCTATGATCTGATTAGACTTTATGAGAAGCTACCAGATA
AAAACCCTGATGAAATAAATATACCGGACGTATACTTTATGTTTTATAAAAGTTTTATTTGCTATGACCATCTTAAACAC
AGAATCTATGTTGTTTATAATGTGTATCCTGAGGAAGACGTAGAATATGAAGAAGTTTTGCAAAAAATTAATGAACTTTT
GCAAGAGGTAAAATCAAATGCTCCTCAATTTCATGACCTTCCATCACAACAAGAAAAGGAAATTTATTACAATTTTACAA
AAGAAGAGTTTTGTAAAATTGTTGAAAAAGCAAAAGAATACATCGAAAAAGGAGACATATTCCAAGTAGTGTTGTCTCAA
AGGTTAAAAGCAGCAGTAAGCTCCCACCCTTTCGAGATATACAGAAGATTAAGGTCAAAAAATCCATCTCCATATCTTTT
TTACATCGATTTTGGTGATTTTCAGCTTCTTGGTTCTTCACCTGAAAGCCTTGTAAGTGTTTTTGGAGACAAAGTGACTA
CAAATCCCATTGCAGGCACAAGGCGAAGAGGAAAAGATGAAGAAGAAGATTTAAGACTTAAAGAGGAACTTTTAAAAGAT
GAAAAGGAAAGGGCAGAGCATGTGATGTTAGTTGACCTTGGAAGAAACGACATAGGAAAAGTTAGTGAATTTGGAAGTGT
AAAAATAGAGCGTTTTATGGAAGTAGATTTTTACTCTCATGTAATGCATATTGTATCGACTGTTTCAGGAAAGTTAAAAA
GAGGACTTACGGCTTTTGATGCTCTTATAGCTTGTCTTCCTGCAGGTACAGTTTCTGGGGCACCAAAAATAAGAGCGATG
GAAATAATAGACGAACTTGAAAATGTGAGAAGGTCTTTTTACGCAGGAGCTGTTGGATATTTTTCCTACAATGGCAATAT
GGACATGTGCATAGCAATAAGGACTATTCTCTTCAAAGAAGGTTATGCTTACGTTCAAGCGGGAGCAGGCATTGTATATG
ATTCAATTCCTGAGATGGAATACTGTGAAACTTTAAATAAGGCAATGGCTCTTAAGGAGGTTCTTTGA

Upstream 100 bases:

>100_bases
GAAATGCTTTTTTTAGTAATACAGGACAAATTGGGTGGCACCGCGAGTCACTTCGCCCCAATGGGCGGAGTGACTTTTTT
AATTTTCAGGAGGTGATAAA

Downstream 100 bases:

>100_bases
TGATTCTGATTATAGATAATTACGATTCCTTTACCTATAATCTTTATCAATATGTGGGAGAAATGAACAAAGAAATATTT
GTAATAAGAAATGATGAAAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVNISKEDFCEHKKRGYVFPVYAEINGDELTPINIFYSLKGKNKFLLESANGGTNWGRYSFIGKDPYLSILSYGKRIKLI
GESEEEKEGLILDEIRDIMNFKYNSLGLDIPFVGGAIGYASYDLIRLYEKLPDKNPDEINIPDVYFMFYKSFICYDHLKH
RIYVVYNVYPEEDVEYEEVLQKINELLQEVKSNAPQFHDLPSQQEKEIYYNFTKEEFCKIVEKAKEYIEKGDIFQVVLSQ
RLKAAVSSHPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVSVFGDKVTTNPIAGTRRRGKDEEEDLRLKEELLKD
EKERAEHVMLVDLGRNDIGKVSEFGSVKIERFMEVDFYSHVMHIVSTVSGKLKRGLTAFDALIACLPAGTVSGAPKIRAM
EIIDELENVRRSFYAGAVGYFSYNGNMDMCIAIRTILFKEGYAYVQAGAGIVYDSIPEMEYCETLNKAMALKEVL

Sequences:

>Translated_475_residues
MVNISKEDFCEHKKRGYVFPVYAEINGDELTPINIFYSLKGKNKFLLESANGGTNWGRYSFIGKDPYLSILSYGKRIKLI
GESEEEKEGLILDEIRDIMNFKYNSLGLDIPFVGGAIGYASYDLIRLYEKLPDKNPDEINIPDVYFMFYKSFICYDHLKH
RIYVVYNVYPEEDVEYEEVLQKINELLQEVKSNAPQFHDLPSQQEKEIYYNFTKEEFCKIVEKAKEYIEKGDIFQVVLSQ
RLKAAVSSHPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVSVFGDKVTTNPIAGTRRRGKDEEEDLRLKEELLKD
EKERAEHVMLVDLGRNDIGKVSEFGSVKIERFMEVDFYSHVMHIVSTVSGKLKRGLTAFDALIACLPAGTVSGAPKIRAM
EIIDELENVRRSFYAGAVGYFSYNGNMDMCIAIRTILFKEGYAYVQAGAGIVYDSIPEMEYCETLNKAMALKEVL
>Mature_475_residues
MVNISKEDFCEHKKRGYVFPVYAEINGDELTPINIFYSLKGKNKFLLESANGGTNWGRYSFIGKDPYLSILSYGKRIKLI
GESEEEKEGLILDEIRDIMNFKYNSLGLDIPFVGGAIGYASYDLIRLYEKLPDKNPDEINIPDVYFMFYKSFICYDHLKH
RIYVVYNVYPEEDVEYEEVLQKINELLQEVKSNAPQFHDLPSQQEKEIYYNFTKEEFCKIVEKAKEYIEKGDIFQVVLSQ
RLKAAVSSHPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVSVFGDKVTTNPIAGTRRRGKDEEEDLRLKEELLKD
EKERAEHVMLVDLGRNDIGKVSEFGSVKIERFMEVDFYSHVMHIVSTVSGKLKRGLTAFDALIACLPAGTVSGAPKIRAM
EIIDELENVRRSFYAGAVGYFSYNGNMDMCIAIRTILFKEGYAYVQAGAGIVYDSIPEMEYCETLNKAMALKEVL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=423, Percent_Identity=37.5886524822695, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1788114, Length=428, Percent_Identity=33.6448598130841, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1786809, Length=258, Percent_Identity=29.8449612403101, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082077, Length=270, Percent_Identity=28.8888888888889, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=471, Percent_Identity=42.8874734607219, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324361, Length=376, Percent_Identity=28.9893617021277, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54583; Mature: 54583

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNISKEDFCEHKKRGYVFPVYAEINGDELTPINIFYSLKGKNKFLLESANGGTNWGRYS
CCCCCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCEEE
FIGKDPYLSILSYGKRIKLIGESEEEKEGLILDEIRDIMNFKYNSLGLDIPFVGGAIGYA
EECCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
SYDLIRLYEKLPDKNPDEINIPDVYFMFYKSFICYDHLKHRIYVVYNVYPEEDVEYEEVL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHH
QKINELLQEVKSNAPQFHDLPSQQEKEIYYNFTKEEFCKIVEKAKEYIEKGDIFQVVLSQ
HHHHHHHHHHHHCCCCCCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHH
RLKAAVSSHPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVSVFGDKVTTNPIAGT
HHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCCCCCCCCC
RRRGKDEEEDLRLKEELLKDEKERAEHVMLVDLGRNDIGKVSEFGSVKIERFMEVDFYSH
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHH
VMHIVSTVSGKLKRGLTAFDALIACLPAGTVSGAPKIRAMEIIDELENVRRSFYAGAVGY
HHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEE
FSYNGNMDMCIAIRTILFKEGYAYVQAGAGIVYDSIPEMEYCETLNKAMALKEVL
EEECCCCHHHHHHHHHHHHCCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNISKEDFCEHKKRGYVFPVYAEINGDELTPINIFYSLKGKNKFLLESANGGTNWGRYS
CCCCCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCEEE
FIGKDPYLSILSYGKRIKLIGESEEEKEGLILDEIRDIMNFKYNSLGLDIPFVGGAIGYA
EECCCHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
SYDLIRLYEKLPDKNPDEINIPDVYFMFYKSFICYDHLKHRIYVVYNVYPEEDVEYEEVL
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHH
QKINELLQEVKSNAPQFHDLPSQQEKEIYYNFTKEEFCKIVEKAKEYIEKGDIFQVVLSQ
HHHHHHHHHHHHCCCCCCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHH
RLKAAVSSHPFEIYRRLRSKNPSPYLFYIDFGDFQLLGSSPESLVSVFGDKVTTNPIAGT
HHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCCCCCCCCC
RRRGKDEEEDLRLKEELLKDEKERAEHVMLVDLGRNDIGKVSEFGSVKIERFMEVDFYSH
CCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHH
VMHIVSTVSGKLKRGLTAFDALIACLPAGTVSGAPKIRAMEIIDELENVRRSFYAGAVGY
HHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEE
FSYNGNMDMCIAIRTILFKEGYAYVQAGAGIVYDSIPEMEYCETLNKAMALKEVL
EEECCCCHHHHHHHHHHHHCCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]