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The map label for this gene is trpC [H]

Identifier: 167040497

GI number: 167040497

Start: 1881191

End: 1881973

Strand: Reverse

Name: trpC [H]

Synonym: Teth514_1866

Alternate gene names: 167040497

Gene position: 1881973-1881191 (Counterclockwise)

Preceding gene: 167040498

Following gene: 167040496

Centisome position: 76.59

GC content: 32.69

Gene sequence:

>783_bases
ATGGTATTAGATGAGATTGTGAGACACAAAAAAAAGGAGGTGGAAGAGAAAAAAAGAATAAAGCCAGTAGAGGAACTAAT
TAACGAAATTAAAGGAGGCTATTCTGGCAATTTCAAGAAAGTACTTCAAAAAGAGGGTATATCAATTATTGGAGAGATAA
AACAAGCCTCTCCATCTAAAGGAATTATAAAAGAAGACTTTGATTCAGTAAAAATTGCAAAAGTGTATGAGAAAGTTGAT
GTTGACGCTATTTCCGTTTTGACAGAGAAGGAATTTTTTAAAGGGGATGACAACTATATCAGGGAAGTAAAAAAAGTGAG
TTCAAAACCTATTTTGAGAAAAGATTTTATTGTGGATGAATACCAAATATATGAATCAAAAATTTTAGGGGCCGACGCAG
TACTTCTCATTGTATCTGTATTAGGTGACAAATTAAGAGATTTTTATAATTTATCTAAAAGTGTAGGTTTAGATGTGCTT
GTGGAAATTCACGACAGACAACAGCTTGAAATAGCACTGGAAGCTGGATGTGATATAATAGGCATAAATAACAGAGACCT
CAAGACTTTTAACGTAGATATAAACACAACAGAAAACTTGATTAAATATATACCTCAAAATACAACAATTGTTTCTGAAA
GTGGAATAAAAACGCCGGAAGATATAAGGTATCTGGCTTCTTTGGGAGTAGATGCTGTATTAATTGGTGAGACTTTTATG
AAAATCATAGATGATATTGATAAAATCAGCGATTTTGTAAAGGAGGCCAAGGGAGGAGGATAA

Upstream 100 bases:

>100_bases
ATTTAAAAGAGGGAATAAAAGTCGCAAATTATCTAATAGATACGGGTTTAGCTCTTGATAAGCTTACAGAGATTTTGGAG
TACCAAAGGAGGCTTAATTG

Downstream 100 bases:

>100_bases
ATTGGTAAAAGTAAAGATTTGCGGACTGAGAAGAAAAGAGGATATTGAATATGCCAATGAGCTAAAACCTGATTATGTAG
GATTTGTCTTTGCAAAAAGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MVLDEIVRHKKKEVEEKKRIKPVEELINEIKGGYSGNFKKVLQKEGISIIGEIKQASPSKGIIKEDFDSVKIAKVYEKVD
VDAISVLTEKEFFKGDDNYIREVKKVSSKPILRKDFIVDEYQIYESKILGADAVLLIVSVLGDKLRDFYNLSKSVGLDVL
VEIHDRQQLEIALEAGCDIIGINNRDLKTFNVDINTTENLIKYIPQNTTIVSESGIKTPEDIRYLASLGVDAVLIGETFM
KIIDDIDKISDFVKEAKGGG

Sequences:

>Translated_260_residues
MVLDEIVRHKKKEVEEKKRIKPVEELINEIKGGYSGNFKKVLQKEGISIIGEIKQASPSKGIIKEDFDSVKIAKVYEKVD
VDAISVLTEKEFFKGDDNYIREVKKVSSKPILRKDFIVDEYQIYESKILGADAVLLIVSVLGDKLRDFYNLSKSVGLDVL
VEIHDRQQLEIALEAGCDIIGINNRDLKTFNVDINTTENLIKYIPQNTTIVSESGIKTPEDIRYLASLGVDAVLIGETFM
KIIDDIDKISDFVKEAKGGG
>Mature_260_residues
MVLDEIVRHKKKEVEEKKRIKPVEELINEIKGGYSGNFKKVLQKEGISIIGEIKQASPSKGIIKEDFDSVKIAKVYEKVD
VDAISVLTEKEFFKGDDNYIREVKKVSSKPILRKDFIVDEYQIYESKILGADAVLLIVSVLGDKLRDFYNLSKSVGLDVL
VEIHDRQQLEIALEAGCDIIGINNRDLKTFNVDINTTENLIKYIPQNTTIVSESGIKTPEDIRYLASLGVDAVLIGETFM
KIIDDIDKISDFVKEAKGGG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=240, Percent_Identity=39.1666666666667, Blast_Score=175, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322638, Length=262, Percent_Identity=35.8778625954198, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29210; Mature: 29210

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLDEIVRHKKKEVEEKKRIKPVEELINEIKGGYSGNFKKVLQKEGISIIGEIKQASPSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHCCCCC
GIIKEDFDSVKIAKVYEKVDVDAISVLTEKEFFKGDDNYIREVKKVSSKPILRKDFIVDE
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
YQIYESKILGADAVLLIVSVLGDKLRDFYNLSKSVGLDVLVEIHDRQQLEIALEAGCDII
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEE
GINNRDLKTFNVDINTTENLIKYIPQNTTIVSESGIKTPEDIRYLASLGVDAVLIGETFM
ECCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCEEHHHHHHH
KIIDDIDKISDFVKEAKGGG
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLDEIVRHKKKEVEEKKRIKPVEELINEIKGGYSGNFKKVLQKEGISIIGEIKQASPSK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHCCCCC
GIIKEDFDSVKIAKVYEKVDVDAISVLTEKEFFKGDDNYIREVKKVSSKPILRKDFIVDE
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
YQIYESKILGADAVLLIVSVLGDKLRDFYNLSKSVGLDVLVEIHDRQQLEIALEAGCDII
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEE
GINNRDLKTFNVDINTTENLIKYIPQNTTIVSESGIKTPEDIRYLASLGVDAVLIGETFM
ECCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCEEHHHHHHH
KIIDDIDKISDFVKEAKGGG
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA