Click here to switch to the map view.

The map label for this gene is trpA [H]

Identifier: 167040494

GI number: 167040494

Start: 1878621

End: 1879409

Strand: Reverse

Name: trpA [H]

Synonym: Teth514_1863

Alternate gene names: 167040494

Gene position: 1879409-1878621 (Counterclockwise)

Preceding gene: 167040495

Following gene: 167040493

Centisome position: 76.48

GC content: 34.22

Gene sequence:

>789_bases
ATGAATAGGATTGACAAAAAGTTTGAAGTTTTAAAAGGAGAAGGGCGCAAAGCCTTAATAACCTTTATAACAGCGGGAGA
CCCGGATATTGAGACGACTTATGATATAGTCTTGGCTTTGGAAGAAGCAGGATCTGATATAATAGAACTGGGAATACCTT
ATTCTGATCCCTTAGCTGATGGACCTACAATACAGGCTTCTTCACAAAGAGCTTTAAATAAAGGTGTAAAAATACCTGAT
ATAATGAAAATAGTAGAAAAAATAAGGTTAAAAAGTGATATCCCTCTGGTTTACCTTGTCTACTATAACTCTATATTCAA
ATATGGCATACAAAAATTTTTAAAAGAGTCAAAAGATGTAGGGATAGATGGGCTTATCATACCAGACTTGCCTATTGAAG
AAAGAAAAGATATTTTAGAAGAAGCAGATAAATACGGTATTTATTTAATACCTTTAGTCGCTCCCACATCAAAAGAAAGA
ATAAAATTAATCACTGAAAATGGCAAAGGATTTGTATATTGTGTTTCAATTACAGGTGTGACAGGAGCAAGAGAAGACAT
TGAAACTGACATTGAAGAATATATGAAGACAGTCTCTCAATACACCAATATGCCAAAGGCGATAGGGTTTGGCATATCTA
CTCCGGAGATGGCGAAAAAATTAAAAGATTTTAGTGATGGGATTATTGTAGGGAGTGCCCTTGTAGAAAGAATTGCTAAA
GGGTATAATAAATCTGAAATGCTGCAGGAAGTTAAGAGTTTTGTATCCAGCTTAAAAGAAGTGTTATGA

Upstream 100 bases:

>100_bases
TGGCTCCAAATTTAACGAAAGACAATATTATCATTGTAAATTTGTCAGGCAGAGGAGATAAAGACGTAAATACAGTTGCA
AAAGTATTGGGGGTGGAGTT

Downstream 100 bases:

>100_bases
AGGTGATGAAAATGGACCTTAAAATAATTGGCGACAAAAATAATAAAATATCAATAAAAATAGGAGATATAACTGTTGGA
AAAGATAAACTAATAATAGC

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNRIDKKFEVLKGEGRKALITFITAGDPDIETTYDIVLALEEAGSDIIELGIPYSDPLADGPTIQASSQRALNKGVKIPD
IMKIVEKIRLKSDIPLVYLVYYNSIFKYGIQKFLKESKDVGIDGLIIPDLPIEERKDILEEADKYGIYLIPLVAPTSKER
IKLITENGKGFVYCVSITGVTGAREDIETDIEEYMKTVSQYTNMPKAIGFGISTPEMAKKLKDFSDGIIVGSALVERIAK
GYNKSEMLQEVKSFVSSLKEVL

Sequences:

>Translated_262_residues
MNRIDKKFEVLKGEGRKALITFITAGDPDIETTYDIVLALEEAGSDIIELGIPYSDPLADGPTIQASSQRALNKGVKIPD
IMKIVEKIRLKSDIPLVYLVYYNSIFKYGIQKFLKESKDVGIDGLIIPDLPIEERKDILEEADKYGIYLIPLVAPTSKER
IKLITENGKGFVYCVSITGVTGAREDIETDIEEYMKTVSQYTNMPKAIGFGISTPEMAKKLKDFSDGIIVGSALVERIAK
GYNKSEMLQEVKSFVSSLKEVL
>Mature_262_residues
MNRIDKKFEVLKGEGRKALITFITAGDPDIETTYDIVLALEEAGSDIIELGIPYSDPLADGPTIQASSQRALNKGVKIPD
IMKIVEKIRLKSDIPLVYLVYYNSIFKYGIQKFLKESKDVGIDGLIIPDLPIEERKDILEEADKYGIYLIPLVAPTSKER
IKLITENGKGFVYCVSITGVTGAREDIETDIEEYMKTVSQYTNMPKAIGFGISTPEMAKKLKDFSDGIIVGSALVERIAK
GYNKSEMLQEVKSFVSSLKEVL

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=263, Percent_Identity=35.7414448669202, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321412, Length=236, Percent_Identity=40.2542372881356, Blast_Score=189, Evalue=4e-49,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29126; Mature: 29126

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIDKKFEVLKGEGRKALITFITAGDPDIETTYDIVLALEEAGSDIIELGIPYSDPLAD
CCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHEEHHHHCCCEEEECCCCCCCCCC
GPTIQASSQRALNKGVKIPDIMKIVEKIRLKSDIPLVYLVYYNSIFKYGIQKFLKESKDV
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
GIDGLIIPDLPIEERKDILEEADKYGIYLIPLVAPTSKERIKLITENGKGFVYCVSITGV
CCCEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCEEEEEEEECCC
TGAREDIETDIEEYMKTVSQYTNMPKAIGFGISTPEMAKKLKDFSDGIIVGSALVERIAK
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHC
GYNKSEMLQEVKSFVSSLKEVL
CCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNRIDKKFEVLKGEGRKALITFITAGDPDIETTYDIVLALEEAGSDIIELGIPYSDPLAD
CCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHEEHHHHCCCEEEECCCCCCCCCC
GPTIQASSQRALNKGVKIPDIMKIVEKIRLKSDIPLVYLVYYNSIFKYGIQKFLKESKDV
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
GIDGLIIPDLPIEERKDILEEADKYGIYLIPLVAPTSKERIKLITENGKGFVYCVSITGV
CCCEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCEEEEEEEECCC
TGAREDIETDIEEYMKTVSQYTNMPKAIGFGISTPEMAKKLKDFSDGIIVGSALVERIAK
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHC
GYNKSEMLQEVKSFVSSLKEVL
CCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA