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The map label for this gene is pyrC

Identifier: 167040450

GI number: 167040450

Start: 1827095

End: 1828390

Strand: Reverse

Name: pyrC

Synonym: Teth514_1817

Alternate gene names: 167040450

Gene position: 1828390-1827095 (Counterclockwise)

Preceding gene: 167040451

Following gene: 167040449

Centisome position: 74.41

GC content: 38.19

Gene sequence:

>1296_bases
ATGAGGATGATTATAAAAAACGGTACGGTAATAGATGGATTTGGAAGTGAAGCCACAGCGGATATATTGATAGACTATGG
TATCATAAAAGCGATTGATAAAAATATACAAGTCTCAGACGGGATAGTGATTGATGCGACAGGAAAATATGTACTTCCGG
GCTTTGTTGATATGCACACCCATTTAAGGCAGCCGGGATTTGAAGAGAAAGAGACTATTAAAACAGGGACAGAGGCGGCA
GCAACAGGAGGGTATACAACTGTTGCCTGCATGCCAAATACAAATCCTCCTATAGACAATGAAATAGTAGTAGAATATGT
AAAAAGCATTGCACAAAGAGAAGGAGTTGTAAAAGTACTGCCTATAGGAGCCATGACAAAGGGAATGAAAGGCGAAGAGA
TAACCGAAATGGCAAAACTTAAAAAAGCAGGGGTTGTTGCCTTATCTGATGATGGTTTTCCAATAATGAGCGCAGGGCTT
ATGAAGAGGATAATGACATACGGAAAAATGTATGACCTTCTTATGATAACTCACTGTGAAGACAAAGCCTTAAGTGGAGA
AGGTGTAATGAATAGCGGAGTAATTTCAACAATGATAGGATTAAAAGGCATACCAAGAGAAGCAGAAGAAGTCATGCTTG
CAAGAAATATTATACTTGCAAAGTCAACTGGTGTAAGGCTTCACATCGCACATATCTCAACAAAGGGAAGTGTCGAACTT
ATAAGAGAAGCGAAAGAAAAGGGAGTGAAAATAACTGCTGAAGTGACTCCTCACAATCTTACCTTGACAGATGAAGCAGT
TTACAATTACGATACAAACACAAAAGCTTATCCACCCTTAAGGACAAGAGAGGATATAGAAGCATTAATAGAAGGATTGA
AAGATGGCACAATAGATGCAATCGCGACAGACCATGCCCCTCACACTAAGGATGACAAAAAAGTACCTTACGACATGGCT
GCTTTTGGAATATCGGGCTTAGAGACAGCCTTCTCTGTGATAAATACTTTCCTTGTACAGACAGGTAAAATAACCATAAA
AGAGTTAGTCAATTACATGAGTATAAATCCTGCGAAAATATTAGGTATATCCAGTGGGATAAAGGTAGGGTCGATAGCGG
ATATTGTAATTGTAGACCCTTATGAAGAGTATGTAGTTGACAAAGATAAATTTAAATCAAAAGGGAAAAACACACCTTTC
CATGGTATGAGGCTAAAAGGAGTTGTGGATTGTACGATAGTGGAAGGAGAAATAAAATACAAAAAGGATAGAAAAACAGA
AAAAGTTGAGGTATAA

Upstream 100 bases:

>100_bases
GCAGCAAATGACAAGTATTCTGTTATAGAAGAACAGGTGACAAACGGTGTCGCTGTCAGGATGGCACTTTTAAAAATACT
TTGTGAAAGGAGAAATTAAA

Downstream 100 bases:

>100_bases
TTATTAATAAATATTTATACAATAAAATGAATAAATTTTCAATAAGAGGATGGTGTAGATGTTTATTGATAAATTAATTG
AGAGTATAAAAGCTAAGAAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRMIIKNGTVIDGFGSEATADILIDYGIIKAIDKNIQVSDGIVIDATGKYVLPGFVDMHTHLRQPGFEEKETIKTGTEAA
ATGGYTTVACMPNTNPPIDNEIVVEYVKSIAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGL
MKRIMTYGKMYDLLMITHCEDKALSGEGVMNSGVISTMIGLKGIPREAEEVMLARNIILAKSTGVRLHIAHISTKGSVEL
IREAKEKGVKITAEVTPHNLTLTDEAVYNYDTNTKAYPPLRTREDIEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
AFGISGLETAFSVINTFLVQTGKITIKELVNYMSINPAKILGISSGIKVGSIADIVIVDPYEEYVVDKDKFKSKGKNTPF
HGMRLKGVVDCTIVEGEIKYKKDRKTEKVEV

Sequences:

>Translated_431_residues
MRMIIKNGTVIDGFGSEATADILIDYGIIKAIDKNIQVSDGIVIDATGKYVLPGFVDMHTHLRQPGFEEKETIKTGTEAA
ATGGYTTVACMPNTNPPIDNEIVVEYVKSIAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGL
MKRIMTYGKMYDLLMITHCEDKALSGEGVMNSGVISTMIGLKGIPREAEEVMLARNIILAKSTGVRLHIAHISTKGSVEL
IREAKEKGVKITAEVTPHNLTLTDEAVYNYDTNTKAYPPLRTREDIEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
AFGISGLETAFSVINTFLVQTGKITIKELVNYMSINPAKILGISSGIKVGSIADIVIVDPYEEYVVDKDKFKSKGKNTPF
HGMRLKGVVDCTIVEGEIKYKKDRKTEKVEV
>Mature_431_residues
MRMIIKNGTVIDGFGSEATADILIDYGIIKAIDKNIQVSDGIVIDATGKYVLPGFVDMHTHLRQPGFEEKETIKTGTEAA
ATGGYTTVACMPNTNPPIDNEIVVEYVKSIAQREGVVKVLPIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGL
MKRIMTYGKMYDLLMITHCEDKALSGEGVMNSGVISTMIGLKGIPREAEEVMLARNIILAKSTGVRLHIAHISTKGSVEL
IREAKEKGVKITAEVTPHNLTLTDEAVYNYDTNTKAYPPLRTREDIEALIEGLKDGTIDAIATDHAPHTKDDKKVPYDMA
AFGISGLETAFSVINTFLVQTGKITIKELVNYMSINPAKILGISSGIKVGSIADIVIVDPYEEYVVDKDKFKSKGKNTPF
HGMRLKGVVDCTIVEGEIKYKKDRKTEKVEV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=373, Percent_Identity=30.8310991957105, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=28.0701754385965, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=25.6756756756757, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4503377, Length=448, Percent_Identity=27.0089285714286, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503051, Length=454, Percent_Identity=25.1101321585903, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI190194363, Length=452, Percent_Identity=25.4424778761062, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI62422571, Length=454, Percent_Identity=25.1101321585903, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=29.0617848970252, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=28.8939051918736, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=372, Percent_Identity=31.4516129032258, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71989490, Length=447, Percent_Identity=27.9642058165548, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17539558, Length=451, Percent_Identity=27.0509977827051, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI86575075, Length=439, Percent_Identity=24.373576309795, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=385, Percent_Identity=27.5324675324675, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24642586, Length=371, Percent_Identity=30.9973045822102, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=27.6029055690073, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137462, Length=455, Percent_Identity=24.8351648351648, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_THEP3 (B0KA35)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665334.1
- ProteinModelPortal:   B0KA35
- SMR:   B0KA35
- GeneID:   5875061
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1344
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- BioCyc:   TPSE340099:TETH39_1344-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46902; Mature: 46902

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMIIKNGTVIDGFGSEATADILIDYGIIKAIDKNIQVSDGIVIDATGKYVLPGFVDMHT
CEEEEECCCEEECCCCCCCCHHEEHHHHHHHHCCCCEECCCEEEECCCCEECCCHHHHHH
HLRQPGFEEKETIKTGTEAAATGGYTTVACMPNTNPPIDNEIVVEYVKSIAQREGVVKVL
HHCCCCCCCHHHHHCCCCHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
PIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGLMKRIMTYGKMYDLLMITHCE
ECCHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEECC
DKALSGEGVMNSGVISTMIGLKGIPREAEEVMLARNIILAKSTGVRLHIAHISTKGSVEL
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCEEEEEEECCCCHHHH
IREAKEKGVKITAEVTPHNLTLTDEAVYNYDTNTKAYPPLRTREDIEALIEGLKDGTIDA
HHHHHHCCCEEEEEECCCEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
IATDHAPHTKDDKKVPYDMAAFGISGLETAFSVINTFLVQTGKITIKELVNYMSINPAKI
EECCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCHHE
LGISSGIKVGSIADIVIVDPYEEYVVDKDKFKSKGKNTPFHGMRLKGVVDCTIVEGEIKY
EEECCCCCCCCEEEEEEECCHHHHHCCCHHHHHCCCCCCCCCEEECCEEEEEEEECEEEE
KKDRKTEKVEV
CCCCCCCCCCC
>Mature Secondary Structure
MRMIIKNGTVIDGFGSEATADILIDYGIIKAIDKNIQVSDGIVIDATGKYVLPGFVDMHT
CEEEEECCCEEECCCCCCCCHHEEHHHHHHHHCCCCEECCCEEEECCCCEECCCHHHHHH
HLRQPGFEEKETIKTGTEAAATGGYTTVACMPNTNPPIDNEIVVEYVKSIAQREGVVKVL
HHCCCCCCCHHHHHCCCCHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
PIGAMTKGMKGEEITEMAKLKKAGVVALSDDGFPIMSAGLMKRIMTYGKMYDLLMITHCE
ECCHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEEEECC
DKALSGEGVMNSGVISTMIGLKGIPREAEEVMLARNIILAKSTGVRLHIAHISTKGSVEL
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCEEEEEEECCCCHHHH
IREAKEKGVKITAEVTPHNLTLTDEAVYNYDTNTKAYPPLRTREDIEALIEGLKDGTIDA
HHHHHHCCCEEEEEECCCEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
IATDHAPHTKDDKKVPYDMAAFGISGLETAFSVINTFLVQTGKITIKELVNYMSINPAKI
EECCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCHHE
LGISSGIKVGSIADIVIVDPYEEYVVDKDKFKSKGKNTPFHGMRLKGVVDCTIVEGEIKY
EEECCCCCCCCEEEEEEECCHHHHHCCCHHHHHCCCCCCCCCEEECCEEEEEEEECEEEE
KKDRKTEKVEV
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA