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The map label for this gene is fumA [C]

Identifier: 167040414

GI number: 167040414

Start: 1783923

End: 1784483

Strand: Reverse

Name: fumA [C]

Synonym: Teth514_1778

Alternate gene names: 167040414

Gene position: 1784483-1783923 (Counterclockwise)

Preceding gene: 167040415

Following gene: 167040413

Centisome position: 72.62

GC content: 36.9

Gene sequence:

>561_bases
ATGTACAGAAAATTAAATACACCTTTACTAGATGAAGTAACAGTACAATTGAAAGCTGGGGATTTGATTTTGCTCTCAGG
AGAGATTTATACTGCAAGGGATGAAGCTCATAAAAGGATGGTTGAAGCACTGGATAGAGGGGAAATGCTACCTTTTGAAA
TTAAAAATTCTATCATTTACTACGTTGGACCTTGTCCTCCTAGACCAGGACAAGTTGTTGGAAGTTGTGGGCCTACTACA
AGTGGAAGAATGGACAAATATGCTCCGAGATTGATTGAATTAGGATTAAAAGGGATGATTGGGAAGGGTGCTAGGTCAGA
AGAAGTTGTAGAATCCATGAAAAAACATAAGGCAGTTTATTTTACTGCTGTAGGAGGAGCTGGTGCTTTACTTGCCCAAA
GAGTCAAAAAAGTGGAAGTAGTAGCTTATGAAGATTTAGGGCCAGAGGCTATATATAAGTTTACGGTCGAAAATTTTCCT
TTAATTGTTACTATAGACATATATGGAAATAACCTCTATGAAATTGAAAGAGAAAAGTACAAAACGCATGTAAAAAGGTG
A

Upstream 100 bases:

>100_bases
TATCCTACCCACATTGCTTCTTTGCCTGTTGCAGTAAATTTGGGATGCCATGCTACGAGACACGCTACTTTTGTATTATA
ATTATGTTTGGAGGGAAAAC

Downstream 100 bases:

>100_bases
TAAAAAATGGCGCTTTTACCTTTGAAAGAGTTGTATCTTGCCTGTTTATATTGTACAAAATGTGATTTACATAAAACTAA
AACCCATATGGTTTTTGGGG

Product: tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVESMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVENFP
LIVTIDIYGNNLYEIEREKYKTHVKR

Sequences:

>Translated_186_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVESMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVENFP
LIVTIDIYGNNLYEIEREKYKTHVKR
>Mature_186_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVESMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVENFP
LIVTIDIYGNNLYEIEREKYKTHVKR

Specific function: It Functions As An Aerobic Enzyme In The Citric Acid Cycle. It Accounts For About 80% Of The Fumarase Activity When The Bacteria Grows Aerobically. [C]

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1787897, Length=175, Percent_Identity=41.7142857142857, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790564, Length=175, Percent_Identity=41.1428571428571, Blast_Score=125, Evalue=1e-30,
Organism=Escherichia coli, GI1789443, Length=177, Percent_Identity=36.1581920903955, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004647 [H]

Pfam domain/function: PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 20796; Mature: 20796

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIY
CCCCCCCCCCCCEEEEEECCCEEEECCCEEECHHHHHHHHHHHHHCCCCCCEEECCCEEE
YVGPCPPRPGQVVGSCGPTTSGRMDKYAPRLIELGLKGMIGKGARSEEVVESMKKHKAVY
EEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEE
FTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVENFPLIVTIDIYGNNLYEIEREKY
EEEECCHHHHHHHHHHHEEEEEECCCCCHHEEEEEECCCCEEEEEEECCCCEEEHHHHHH
KTHVKR
HHHCCC
>Mature Secondary Structure
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIY
CCCCCCCCCCCCEEEEEECCCEEEECCCEEECHHHHHHHHHHHHHCCCCCCEEECCCEEE
YVGPCPPRPGQVVGSCGPTTSGRMDKYAPRLIELGLKGMIGKGARSEEVVESMKKHKAVY
EEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEE
FTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVENFPLIVTIDIYGNNLYEIEREKY
EEEECCHHHHHHHHHHHEEEEEECCCCCHHEEEEEECCCCEEEEEEECCCCEEEHHHHHH
KTHVKR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]