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The map label for this gene is thiN [H]

Identifier: 167040383

GI number: 167040383

Start: 1749862

End: 1750497

Strand: Reverse

Name: thiN [H]

Synonym: Teth514_1746

Alternate gene names: 167040383

Gene position: 1750497-1749862 (Counterclockwise)

Preceding gene: 167040384

Following gene: 167040382

Centisome position: 71.24

GC content: 30.66

Gene sequence:

>636_bases
ATGAAGGTCTTAATTATTTCTAATGGGGATATAAAAGATTATAATTTTTATAAAAAGCTGATAAAAGATGCAGATATGGT
TATATGTGCAGATGGTGGAGCAAATCATGCCTACCGAATGAAACTAAAACCTCATTTAATAGTGGGAGATTTAGATTCAA
TAAAAGAAGAAGTTTTAGAATTTTATGAAAAAGAGGGGGTAAGGATAGAAAAATATCCACCCATGAAGGATGAGACAGAT
ACACAACTGGCAATGTTAAAAGCGATAGAATTAGGTGCAAGAGAAATCACTTTTATAGGAGTAATTGGTGAAAGGCTTGA
CCATTCTTATGCAAATCTTTCACTTTTGTTGTATCTCCTAAAACGCAATATTAAGGGTAAAATTGTAAATGAAATGAATG
AAATATATTTGATTAATAAATTTATAGAGGTTGAAGGTAAAAAAGGAGAACTTTTATCTTTACTGCCTTATTCAAAGGAA
GTAAATGGAATATACACTAAAGGTTTGTTTTATGGTCTTTCAGGTCAAAGTATGGATTTAGAGATGCCTTACGGTATAAG
CAATGTTTTTACAGATAATAAAGCTACAATAGAGATAGAAGAAGGGCTTTTATTAGTGATAAAGCCAAGAGAATAG

Upstream 100 bases:

>100_bases
TGGTTGAGGCAGGAGCTGATATAATTGTAGCTGGTTCTGCAATTTTTGAGTCTTCAAATCCTGCACAAACTATAAAAGAA
TTTAGAAAGGCAGTAGAAAA

Downstream 100 bases:

>100_bases
TTTCAAAATCCCCTTCCAATGAATAGTATATAGTAACTAAAGAGGGAAGGGGTGTTTTTATGGATAAATTTTTTTATAAG
CTGAAGCGATTAAATAGGCA

Product: thiamine pyrophosphokinase

Products: NA

Alternate protein names: TPK; Thiamine diphosphokinase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKVLIISNGDIKDYNFYKKLIKDADMVICADGGANHAYRMKLKPHLIVGDLDSIKEEVLEFYEKEGVRIEKYPPMKDETD
TQLAMLKAIELGAREITFIGVIGERLDHSYANLSLLLYLLKRNIKGKIVNEMNEIYLINKFIEVEGKKGELLSLLPYSKE
VNGIYTKGLFYGLSGQSMDLEMPYGISNVFTDNKATIEIEEGLLLVIKPRE

Sequences:

>Translated_211_residues
MKVLIISNGDIKDYNFYKKLIKDADMVICADGGANHAYRMKLKPHLIVGDLDSIKEEVLEFYEKEGVRIEKYPPMKDETD
TQLAMLKAIELGAREITFIGVIGERLDHSYANLSLLLYLLKRNIKGKIVNEMNEIYLINKFIEVEGKKGELLSLLPYSKE
VNGIYTKGLFYGLSGQSMDLEMPYGISNVFTDNKATIEIEEGLLLVIKPRE
>Mature_211_residues
MKVLIISNGDIKDYNFYKKLIKDADMVICADGGANHAYRMKLKPHLIVGDLDSIKEEVLEFYEKEGVRIEKYPPMKDETD
TQLAMLKAIELGAREITFIGVIGERLDHSYANLSLLLYLLKRNIKGKIVNEMNEIYLINKFIEVEGKKGELLSLLPYSKE
VNGIYTKGLFYGLSGQSMDLEMPYGISNVFTDNKATIEIEEGLLLVIKPRE

Specific function: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate [H]

COG id: COG1564

COG function: function code H; Thiamine pyrophosphokinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine pyrophosphokinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006282
- InterPro:   IPR007373
- InterPro:   IPR007371 [H]

Pfam domain/function: PF04263 TPK_catalytic [H]

EC number: =2.7.6.2 [H]

Molecular weight: Translated: 24002; Mature: 24002

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIISNGDIKDYNFYKKLIKDADMVICADGGANHAYRMKLKPHLIVGDLDSIKEEVLE
CEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCEEEECCHHHHHHHHHH
FYEKEGVRIEKYPPMKDETDTQLAMLKAIELGAREITFIGVIGERLDHSYANLSLLLYLL
HHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCCCHHHHHHHHHHH
KRNIKGKIVNEMNEIYLINKFIEVEGKKGELLSLLPYSKEVNGIYTKGLFYGLSGQSMDL
HCCCCCHHHHCCCEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEECEEEEECCCCCEEE
EMPYGISNVFTDNKATIEIEEGLLLVIKPRE
ECCCCCHHEECCCCEEEEECCCEEEEEECCC
>Mature Secondary Structure
MKVLIISNGDIKDYNFYKKLIKDADMVICADGGANHAYRMKLKPHLIVGDLDSIKEEVLE
CEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCEEEECCHHHHHHHHHH
FYEKEGVRIEKYPPMKDETDTQLAMLKAIELGAREITFIGVIGERLDHSYANLSLLLYLL
HHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCCCHHHHHHHHHHH
KRNIKGKIVNEMNEIYLINKFIEVEGKKGELLSLLPYSKEVNGIYTKGLFYGLSGQSMDL
HCCCCCHHHHCCCEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEECEEEEECCCCCEEE
EMPYGISNVFTDNKATIEIEEGLLLVIKPRE
ECCCCCHHEECCCCEEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]