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The map label for this gene is dut

Identifier: 167040273

GI number: 167040273

Start: 1653376

End: 1653822

Strand: Reverse

Name: dut

Synonym: Teth514_1636

Alternate gene names: 167040273

Gene position: 1653822-1653376 (Counterclockwise)

Preceding gene: 167040274

Following gene: 167040272

Centisome position: 67.3

GC content: 35.79

Gene sequence:

>447_bases
ATGTCAATAATACTTAAGATTAAAAAAACTGATGATGCTAAAGACTTACCTTTGCCTGCTTATATGAGTGAAGGAGCCGC
TGGGATGGATTTATATGCTAATGTTAAAGAGGAAGTCATATTACAGCCTGGCGAAATAAAACTAATTCCAACAGGTATAC
AAATTGAACTTCCTCCAAATTTTGAGGCCCAAATAAGGCCAAGAAGTGGCCTAGCTTTAAACTATGGAATAACCCTTTTA
AATACTCCTGGCACAATTGATTCTGATTACAGAGGAGAAATAAAATTAATAGTCATCAATTTAGGAAAAGAAGCAGTCAA
AATCGCAAGGGGACAAAGAATTGCTCAAATGGTAATCAATCAGATAGTAAGACCAACAATAGTAGAGGCAGAAATCCTTT
CAGAAACAAAAAGAGATGAGGGAGGATTTGGCCATACCGGTATATAA

Upstream 100 bases:

>100_bases
GACGAAATAAATGATTTAGCTAAAAAAATTATAAATCCTGCTGACATGAGCATAGCCGTGGTTGGAAAATTAAACAAAAG
AGATAAAGGGTGGTTAGAAA

Downstream 100 bases:

>100_bases
GGAGGGGTTCTATGCGGTTAAGCGAATTTGGAAATAAAGAAATTGTAAATTTAACGGATGGAAGAAGATGGGGATTAGTA
GAAGATTCAGATTTAGTTAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MSIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPNFEAQIRPRSGLALNYGITLL
NTPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVINQIVRPTIVEAEILSETKRDEGGFGHTGI

Sequences:

>Translated_148_residues
MSIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPNFEAQIRPRSGLALNYGITLL
NTPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVINQIVRPTIVEAEILSETKRDEGGFGHTGI
>Mature_147_residues
SIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPNFEAQIRPRSGLALNYGITLLN
TPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVINQIVRPTIVEAEILSETKRDEGGFGHTGI

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=129, Percent_Identity=40.3100775193798, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI4503423, Length=129, Percent_Identity=40.3100775193798, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI70906441, Length=129, Percent_Identity=40.3100775193798, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1790071, Length=146, Percent_Identity=42.4657534246575, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=147, Percent_Identity=41.4965986394558, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319729, Length=131, Percent_Identity=35.1145038167939, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921126, Length=130, Percent_Identity=32.3076923076923, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583610, Length=130, Percent_Identity=32.3076923076923, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_THEP3 (B0K9P1)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665190.1
- ProteinModelPortal:   B0K9P1
- SMR:   B0K9P1
- GeneID:   5875220
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1200
- HOGENOM:   HBG436079
- OMA:   HGIALVN
- ProtClustDB:   CLSK901205
- BioCyc:   TPSE340099:TETH39_1200-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16164; Mature: 16033

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: BINDING 81-81 BINDING 95-95

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPN
CEEEEEEECCCCCCCCCCCHHHCCCCCCCEEEECCCHHEEECCCCEEEEECCEEEEECCC
FEAQIRPRSGLALNYGITLLNTPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVIN
CCEEEECCCCEEEECCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHCCHHHHHHHHH
QIVRPTIVEAEILSETKRDEGGFGHTGI
HHCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SIILKIKKTDDAKDLPLPAYMSEGAAGMDLYANVKEEVILQPGEIKLIPTGIQIELPPN
EEEEEEECCCCCCCCCCCHHHCCCCCCCEEEECCCHHEEECCCCEEEEECCEEEEECCC
FEAQIRPRSGLALNYGITLLNTPGTIDSDYRGEIKLIVINLGKEAVKIARGQRIAQMVIN
CCEEEECCCCEEEECCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHCCHHHHHHHHH
QIVRPTIVEAEILSETKRDEGGFGHTGI
HHCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA