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The map label for this gene is mntH [H]

Identifier: 167040231

GI number: 167040231

Start: 1611871

End: 1613109

Strand: Direct

Name: mntH [H]

Synonym: Teth514_1593

Alternate gene names: 167040231

Gene position: 1611871-1613109 (Clockwise)

Preceding gene: 167040230

Following gene: 167040232

Centisome position: 65.6

GC content: 48.83

Gene sequence:

>1239_bases
ATGGAAGATCGAAAAACTTTGTGGCAAAAAATAGCCAGCATAGGACCGGGTGCCATTGTCGCTGCAGCATTTATAGGCCC
GGGTACTGTAACCACCTGCACCCTGGCGGGCGTCAATTACAAATACACTCTGCTGTGGGCCTTACTGTTTTCAACCATAG
CGACTATAATACTTCAGGAAATGTCGGCTCGCATCGGGATAGTAGCCAATAAGGGATTAGGAAGCACCATCAGAAAAACC
TTTGAGGAAAACCCAACGGCCAAAATTGTCGTAATAGCTCTTGTGATCGCAGCCCTGGGAATTGGGAACTCCGCCTTCCA
GAGCGGCAATATAAGTGGCGCCTCTATGGGATTGCAGGTGATTCTTGGAGGTTCAAAACAAGTCTGGGTAGTCCTCATCG
CGCTGATAGCAGGATTCCTCCTCTGGACCAGCAGTTACAAGTTAATCGAAAAGGTATTGGTCGGTATAGTTATAATGATG
AGCATTGTCTTCGTCGCCACAGCCGTAGTGATCTCTCCCAACTGGGGTGAGGTTTTTAGGGGAATCTTTGTTCCAACGAT
TCCACCAGGCGCCCTCATAGTAACCCTCGGACTCATAGGGACAACCGTTGTGCCGTATAACCTGTACCTTCATTCATCCA
TTACAGCCGAACGCTGGGGTAGTTACAAAGACAAGAGAGAAGCCATATCGGAATCAAGAGCCGATACCATGCTGTCTATA
GGTCTGGGCGGAATTATATCCATGGCCATAATCATTACTTCCTCTTCCATGTTCAGCACCGGCGTACAAATTAAAACCGC
CGCCGACATGGCGAGCCAGCTGGAGCCCCTGCTGGGGCCATGGGCAAAATGGTTTTTCGCAATAGGCCTGTTCTGCGCCG
GGATTTCTTCGGCCATAACGGCACCCATGGCCGCCGCCTATGCTATAACTGGCGTCCTCGGGCTGAAAAGCGACCTAAAG
GAAAGGCATTTTCGTATAATATGGCTGCTGGTATTACTAATTGGTGCCACGGTGGCCTTTTTGGGCGCCAACCCAGTACA
GGTAATAGTTTTTGCCCAGGCGGTAAACGGCGTACTGCTTCCCATCTCGGCAATACTCTTGCTTGTGGTAATAAACAACC
AAAAGATCATGAAAGAATTTGCAAACACCACCGTATCCAATATACTCGGGTATTTCGTCGTAGTCGTAACCGTAATTCTC
GGGTTGAGGATGTTCCTGACAGCCCTAAAGATAATATAA

Upstream 100 bases:

>100_bases
GAATTCCTTTGAAAATATATAGCAGAACCCCTTAATTTGTGAGGATTTTGGAGTTCTGCAAAGACCTAAATAAAAAAATG
CTAAGGAGGTTATTTATGGT

Downstream 100 bases:

>100_bases
TTGGTGTTAGTATAATATTGTAGACACTATAACTTGAACAAGGTAAAATAGAATTACAAAGAGAGGAAGTGTCTACAAGA
TGTCAAAGTGACAAAGAAAA

Product: natural resistance-associated macrophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MEDRKTLWQKIASIGPGAIVAAAFIGPGTVTTCTLAGVNYKYTLLWALLFSTIATIILQEMSARIGIVANKGLGSTIRKT
FEENPTAKIVVIALVIAALGIGNSAFQSGNISGASMGLQVILGGSKQVWVVLIALIAGFLLWTSSYKLIEKVLVGIVIMM
SIVFVATAVVISPNWGEVFRGIFVPTIPPGALIVTLGLIGTTVVPYNLYLHSSITAERWGSYKDKREAISESRADTMLSI
GLGGIISMAIIITSSSMFSTGVQIKTAADMASQLEPLLGPWAKWFFAIGLFCAGISSAITAPMAAAYAITGVLGLKSDLK
ERHFRIIWLLVLLIGATVAFLGANPVQVIVFAQAVNGVLLPISAILLLVVINNQKIMKEFANTTVSNILGYFVVVVTVIL
GLRMFLTALKII

Sequences:

>Translated_412_residues
MEDRKTLWQKIASIGPGAIVAAAFIGPGTVTTCTLAGVNYKYTLLWALLFSTIATIILQEMSARIGIVANKGLGSTIRKT
FEENPTAKIVVIALVIAALGIGNSAFQSGNISGASMGLQVILGGSKQVWVVLIALIAGFLLWTSSYKLIEKVLVGIVIMM
SIVFVATAVVISPNWGEVFRGIFVPTIPPGALIVTLGLIGTTVVPYNLYLHSSITAERWGSYKDKREAISESRADTMLSI
GLGGIISMAIIITSSSMFSTGVQIKTAADMASQLEPLLGPWAKWFFAIGLFCAGISSAITAPMAAAYAITGVLGLKSDLK
ERHFRIIWLLVLLIGATVAFLGANPVQVIVFAQAVNGVLLPISAILLLVVINNQKIMKEFANTTVSNILGYFVVVVTVIL
GLRMFLTALKII
>Mature_412_residues
MEDRKTLWQKIASIGPGAIVAAAFIGPGTVTTCTLAGVNYKYTLLWALLFSTIATIILQEMSARIGIVANKGLGSTIRKT
FEENPTAKIVVIALVIAALGIGNSAFQSGNISGASMGLQVILGGSKQVWVVLIALIAGFLLWTSSYKLIEKVLVGIVIMM
SIVFVATAVVISPNWGEVFRGIFVPTIPPGALIVTLGLIGTTVVPYNLYLHSSITAERWGSYKDKREAISESRADTMLSI
GLGGIISMAIIITSSSMFSTGVQIKTAADMASQLEPLLGPWAKWFFAIGLFCAGISSAITAPMAAAYAITGVLGLKSDLK
ERHFRIIWLLVLLIGATVAFLGANPVQVIVFAQAVNGVLLPISAILLLVVINNQKIMKEFANTTVSNILGYFVVVVTVIL
GLRMFLTALKII

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=451, Percent_Identity=25.4988913525499, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI295293171, Length=450, Percent_Identity=24.2222222222222, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI295293169, Length=450, Percent_Identity=24.2222222222222, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI295293175, Length=450, Percent_Identity=24.2222222222222, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI295293173, Length=450, Percent_Identity=24.2222222222222, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI10835169, Length=450, Percent_Identity=24.2222222222222, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI295293167, Length=450, Percent_Identity=24.2222222222222, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI295293178, Length=450, Percent_Identity=24.2222222222222, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1788736, Length=401, Percent_Identity=26.9326683291771, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17569473, Length=387, Percent_Identity=27.390180878553, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193210616, Length=430, Percent_Identity=24.6511627906977, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71999499, Length=450, Percent_Identity=24, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993856, Length=240, Percent_Identity=27.0833333333333, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323062, Length=413, Percent_Identity=27.3607748184019, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648607, Length=454, Percent_Identity=23.1277533039648, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362176, Length=454, Percent_Identity=23.1277533039648, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648609, Length=454, Percent_Identity=23.1277533039648, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553443, Length=425, Percent_Identity=24, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 43747; Mature: 43747

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDRKTLWQKIASIGPGAIVAAAFIGPGTVTTCTLAGVNYKYTLLWALLFSTIATIILQE
CCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
MSARIGIVANKGLGSTIRKTFEENPTAKIVVIALVIAALGIGNSAFQSGNISGASMGLQV
HHHHEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCHHCCEEE
ILGGSKQVWVVLIALIAGFLLWTSSYKLIEKVLVGIVIMMSIVFVATAVVISPNWGEVFR
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GIFVPTIPPGALIVTLGLIGTTVVPYNLYLHSSITAERWGSYKDKREAISESRADTMLSI
CCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHH
GLGGIISMAIIITSSSMFSTGVQIKTAADMASQLEPLLGPWAKWFFAIGLFCAGISSAIT
HHHHHHHHHHHHCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APMAAAYAITGVLGLKSDLKERHFRIIWLLVLLIGATVAFLGANPVQVIVFAQAVNGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHCCHHH
PISAILLLVVINNQKIMKEFANTTVSNILGYFVVVVTVILGLRMFLTALKII
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDRKTLWQKIASIGPGAIVAAAFIGPGTVTTCTLAGVNYKYTLLWALLFSTIATIILQE
CCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
MSARIGIVANKGLGSTIRKTFEENPTAKIVVIALVIAALGIGNSAFQSGNISGASMGLQV
HHHHEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCHHCCEEE
ILGGSKQVWVVLIALIAGFLLWTSSYKLIEKVLVGIVIMMSIVFVATAVVISPNWGEVFR
EECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GIFVPTIPPGALIVTLGLIGTTVVPYNLYLHSSITAERWGSYKDKREAISESRADTMLSI
CCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHH
GLGGIISMAIIITSSSMFSTGVQIKTAADMASQLEPLLGPWAKWFFAIGLFCAGISSAIT
HHHHHHHHHHHHCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APMAAAYAITGVLGLKSDLKERHFRIIWLLVLLIGATVAFLGANPVQVIVFAQAVNGVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHCCHHH
PISAILLLVVINNQKIMKEFANTTVSNILGYFVVVVTVILGLRMFLTALKII
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]