Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 167040057

GI number: 167040057

Start: 1452142

End: 1453599

Strand: Direct

Name: zwf [H]

Synonym: Teth514_1417

Alternate gene names: 167040057

Gene position: 1452142-1453599 (Clockwise)

Preceding gene: 167040056

Following gene: 167040058

Centisome position: 59.1

GC content: 35.05

Gene sequence:

>1458_bases
ATGGTTAAAAATAATATATCTAATATAATGGTTATATTTGGCGGGACAGGGGATTTAACTCACAGAAAACTTATGCCTGC
TTTGTACAATTTGAAATACCAAAAAATTCTTCCTGAAAATTTTGCTGTTGTATCCATAGGAAGAAGAGATAAAACAGAGG
AACAATATAGGAAGGAAGTATTAGAGTCTGTTAAAAATTATTCGAGATTTGACATTGATGAAAAAGTTTGGCAAGATTTA
AGTGAAAGGATATATTATAAGAGATTTGACTTTGTATATGATAATGGCTATATGGAATTAAGTTCTTTTTTAAAAGAACT
TGATGAAAATTACAATACAAAGGGCAATAGGGTATACTATCTTGCAGTAGCTCCAGAATATTTCGGTATAATTGTTGAAA
AACTCTATAGGCATGGTATGGTAAATAATGAGACTTCCTGGCAAAGGGTGGTCATAGAAAAACCTTTTGGAGAAGATTTG
GAATCGGCACGGAAATTAAATAAAATGATAACTGATGTTTTCACGGAAAGGAATACCTACAGGATAGACCATTATCTGGG
AAAAGAGATGCTTCAGAACATAATGGTAATTAGATTTGCTAATGTATTTTTTGAACCTGTGTGGAACAGAAGGTATATTG
ATAATGTTCAGATTTCTTCAAATGAAATAGTTGGAATAGAAAATCGCGGTGGGTATTATGAAAAAGCCGGGGCGTTACGG
GATATGGTACAAAATCACATGATGCAACTTCTAACTTTAACGGCAATGGAACCGCCTGTAAATCTCGATACAGAATCTAT
AAGAGATGAGAAGGTAAAAGTTCTGAAGTCTTTGGAGATATTTACTCCAGAGGCTGTTGAGAAAAATGTTGTGAGAGGGC
AGTATGCAGGATATAGACAAGAAGACAAAGTTTCCCCTACTTCTAATACAGAGACATTTGTAGCTTTGAAAGTGCATGTG
GAAAATTTTCGCTGGGCAGGAGTACCTTTCTACATTCGCACGGGCAAAAGAATGCCGGAAAAGTCTACACAAATTGTAAT
ACAGTTCAAACCGTTGCCAGGAATCTTGTATTTTAAAGAATATAAAAATTTATTGCCAAATTTATTAGTTATAAAAATTC
AACCTGAGGAAGGTGTAAAGCTTCAATTTAATGCAAAAGTTCCTGGGGCAGGAGATATCACCATACAACCTGTAGATATG
GATTTTTGTCAAAATTGCCAGATTTCAAATAATTCTCCAGAAGCTTATGAAAGACTTCTTTACGATGTCATGAGAGGAGA
TTCTACTTTATTTACGCGATGGGATGAGGTAGAATATTCTTGGAAGTTTGTAGATGCTATTGCTGAAGCATGGAAAGACA
AAACGCCTGACTTTCCTAATTATCAGCCAGGGACCTGGGGACCTAAAGAAGCAAATGAGCTGTTACTAAGGGACAATAGA
ATGTGGTGGAATGTATAA

Upstream 100 bases:

>100_bases
TTCAGAGCAAGAAGATACATTTGCAGGAAAGGTTGTAGCTGCTTTGAGAAATGAGTTTGGAGGACATGCGGTGGAAAAGA
ATTAACACGAGGTGGTTTAT

Downstream 100 bases:

>100_bases
AAGAAGGGGGTAAATTAAATGAAAATATACGATATTTCAATGGAAATTCACGAAAATATGACTGTTTACAAAAATAAAGA
AGAGAAAAGGCCTAAACATA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MVKNNISNIMVIFGGTGDLTHRKLMPALYNLKYQKILPENFAVVSIGRRDKTEEQYRKEVLESVKNYSRFDIDEKVWQDL
SERIYYKRFDFVYDNGYMELSSFLKELDENYNTKGNRVYYLAVAPEYFGIIVEKLYRHGMVNNETSWQRVVIEKPFGEDL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNEIVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIFTPEAVEKNVVRGQYAGYRQEDKVSPTSNTETFVALKVHV
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIQPVDM
DFCQNCQISNNSPEAYERLLYDVMRGDSTLFTRWDEVEYSWKFVDAIAEAWKDKTPDFPNYQPGTWGPKEANELLLRDNR
MWWNV

Sequences:

>Translated_485_residues
MVKNNISNIMVIFGGTGDLTHRKLMPALYNLKYQKILPENFAVVSIGRRDKTEEQYRKEVLESVKNYSRFDIDEKVWQDL
SERIYYKRFDFVYDNGYMELSSFLKELDENYNTKGNRVYYLAVAPEYFGIIVEKLYRHGMVNNETSWQRVVIEKPFGEDL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNEIVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIFTPEAVEKNVVRGQYAGYRQEDKVSPTSNTETFVALKVHV
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIQPVDM
DFCQNCQISNNSPEAYERLLYDVMRGDSTLFTRWDEVEYSWKFVDAIAEAWKDKTPDFPNYQPGTWGPKEANELLLRDNR
MWWNV
>Mature_485_residues
MVKNNISNIMVIFGGTGDLTHRKLMPALYNLKYQKILPENFAVVSIGRRDKTEEQYRKEVLESVKNYSRFDIDEKVWQDL
SERIYYKRFDFVYDNGYMELSSFLKELDENYNTKGNRVYYLAVAPEYFGIIVEKLYRHGMVNNETSWQRVVIEKPFGEDL
ESARKLNKMITDVFTERNTYRIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNEIVGIENRGGYYEKAGALR
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIFTPEAVEKNVVRGQYAGYRQEDKVSPTSNTETFVALKVHV
ENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKEYKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIQPVDM
DFCQNCQISNNSPEAYERLLYDVMRGDSTLFTRWDEVEYSWKFVDAIAEAWKDKTPDFPNYQPGTWGPKEANELLLRDNR
MWWNV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=484, Percent_Identity=35.5371900826446, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI108773793, Length=484, Percent_Identity=35.5371900826446, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI52145310, Length=355, Percent_Identity=30.4225352112676, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=41.7177914110429, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17538218, Length=483, Percent_Identity=38.3022774327122, Blast_Score=323, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=36.2704918032787, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643350, Length=487, Percent_Identity=35.1129363449692, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24643352, Length=487, Percent_Identity=35.1129363449692, Blast_Score=274, Evalue=8e-74,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=27.4633123689727, Blast_Score=201, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56990; Mature: 56990

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKNNISNIMVIFGGTGDLTHRKLMPALYNLKYQKILPENFAVVSIGRRDKTEEQYRKEV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCHHHHHHHH
LESVKNYSRFDIDEKVWQDLSERIYYKRFDFVYDNGYMELSSFLKELDENYNTKGNRVYY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEE
LAVAPEYFGIIVEKLYRHGMVNNETSWQRVVIEKPFGEDLESARKLNKMITDVFTERNTY
EEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
RIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNEIVGIENRGGYYEKAGALR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHH
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIFTPEAVEKNVVRGQYAGYRQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
EDKVSPTSNTETFVALKVHVENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKE
CCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCCEEEEEEECCCCEEHHHH
YKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIQPVDMDFCQNCQISNNSPEAYERLL
HHHCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEECCHHHHCCCCCCCCCHHHHHHHH
YDVMRGDSTLFTRWDEVEYSWKFVDAIAEAWKDKTPDFPNYQPGTWGPKEANELLLRDNR
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEEECCC
MWWNV
EEECC
>Mature Secondary Structure
MVKNNISNIMVIFGGTGDLTHRKLMPALYNLKYQKILPENFAVVSIGRRDKTEEQYRKEV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCHHHHHHHH
LESVKNYSRFDIDEKVWQDLSERIYYKRFDFVYDNGYMELSSFLKELDENYNTKGNRVYY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEE
LAVAPEYFGIIVEKLYRHGMVNNETSWQRVVIEKPFGEDLESARKLNKMITDVFTERNTY
EEECHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
RIDHYLGKEMLQNIMVIRFANVFFEPVWNRRYIDNVQISSNEIVGIENRGGYYEKAGALR
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHH
DMVQNHMMQLLTLTAMEPPVNLDTESIRDEKVKVLKSLEIFTPEAVEKNVVRGQYAGYRQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCC
EDKVSPTSNTETFVALKVHVENFRWAGVPFYIRTGKRMPEKSTQIVIQFKPLPGILYFKE
CCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCCCCCCEEEEEEECCCCEEHHHH
YKNLLPNLLVIKIQPEEGVKLQFNAKVPGAGDITIQPVDMDFCQNCQISNNSPEAYERLL
HHHCCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEECCHHHHCCCCCCCCCHHHHHHHH
YDVMRGDSTLFTRWDEVEYSWKFVDAIAEAWKDKTPDFPNYQPGTWGPKEANELLLRDNR
HHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHEEECCC
MWWNV
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]