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The map label for this gene is yqeC [H]

Identifier: 167040056

GI number: 167040056

Start: 1451230

End: 1452126

Strand: Direct

Name: yqeC [H]

Synonym: Teth514_1416

Alternate gene names: 167040056

Gene position: 1451230-1452126 (Clockwise)

Preceding gene: 167040055

Following gene: 167040057

Centisome position: 59.06

GC content: 38.35

Gene sequence:

>897_bases
ATGAAGGTAGGTTTAATTGGATTAGGACGAATGGGATTTAATCTTGCTTTAAATATGAGAGACCATGGGCATGAGGTAGT
GGTATATAACAGGTCACCTGAGAAAATAAAAGAGGCTGAAAAGGAAGGAATAAAAGGAGCTTATACAATTGAAGATTTAG
TAAAAAACCTTGAAAGAAGAAGAATAATATGGCTTATGGTACCTGCAGGAGACCCTGTTGACGAAATGATAGAAAAATTA
GTTCCCTTGCTTGAAGAACATGACATCATAATAGACGGCGGCAATTCCTACTATAAAGATACTTTAAGAAGGTATGAGAT
GCTTAAAGAAAAAGGAATTGATTTTGTAGATGTGGGCACAAGTGGAGGAATTGAAGGAGCAAGACATGGGGCTTGCACCA
TGATAGGAGCAGAAGATGAGGTCTTTAAATATATTGAACCTCTAATTAGGGATATAAGTGCGGAAAACGGTTATTTACAT
ACAGGAAAAAACGGTTCAGGACATTTTGCAAAAATGGTTCATAACGGCATAGAATACGGAATGATGCAGGCTATAGGAGA
AGGGTTTGAGGTTTTAGAGAAAAGTCAGTTTGATTTTGATTTAAAAGAAGTGGCCAGAGTTTGGAGTCATGGGTCAGTGA
TTCGCGGATGGCTTATGGAGCTTATGGAAAAAGCTTTTGAAAAAGACCCTAAATTGTCTGGGATAAAAGGAGTAATGCAC
TCTTCTGGAGAAGGACTCTGGACGGTAGAAGAAGCTTTAAACCTCAAAGTGCCAGTGCCTGTAATTGCACAGTCTTTATT
TATGAGATATCGTTCAGAGCAAGAAGATACATTTGCAGGAAAGGTTGTAGCTGCTTTGAGAAATGAGTTTGGAGGACATG
CGGTGGAAAAGAATTAA

Upstream 100 bases:

>100_bases
GATTTTCGTCATTTAAAATTTTAAAATGTATGATATAATTATATAACACCCTCAACTAAAAAATATTATACAACAATAAT
TATTATTAAGGAGGATTTAT

Downstream 100 bases:

>100_bases
CACGAGGTGGTTTATATGGTTAAAAATAATATATCTAATATAATGGTTATATTTGGCGGGACAGGGGATTTAACTCACAG
AAAACTTATGCCTGCTTTGT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKVGLIGLGRMGFNLALNMRDHGHEVVVYNRSPEKIKEAEKEGIKGAYTIEDLVKNLERRRIIWLMVPAGDPVDEMIEKL
VPLLEEHDIIIDGGNSYYKDTLRRYEMLKEKGIDFVDVGTSGGIEGARHGACTMIGAEDEVFKYIEPLIRDISAENGYLH
TGKNGSGHFAKMVHNGIEYGMMQAIGEGFEVLEKSQFDFDLKEVARVWSHGSVIRGWLMELMEKAFEKDPKLSGIKGVMH
SSGEGLWTVEEALNLKVPVPVIAQSLFMRYRSEQEDTFAGKVVAALRNEFGGHAVEKN

Sequences:

>Translated_298_residues
MKVGLIGLGRMGFNLALNMRDHGHEVVVYNRSPEKIKEAEKEGIKGAYTIEDLVKNLERRRIIWLMVPAGDPVDEMIEKL
VPLLEEHDIIIDGGNSYYKDTLRRYEMLKEKGIDFVDVGTSGGIEGARHGACTMIGAEDEVFKYIEPLIRDISAENGYLH
TGKNGSGHFAKMVHNGIEYGMMQAIGEGFEVLEKSQFDFDLKEVARVWSHGSVIRGWLMELMEKAFEKDPKLSGIKGVMH
SSGEGLWTVEEALNLKVPVPVIAQSLFMRYRSEQEDTFAGKVVAALRNEFGGHAVEKN
>Mature_298_residues
MKVGLIGLGRMGFNLALNMRDHGHEVVVYNRSPEKIKEAEKEGIKGAYTIEDLVKNLERRRIIWLMVPAGDPVDEMIEKL
VPLLEEHDIIIDGGNSYYKDTLRRYEMLKEKGIDFVDVGTSGGIEGARHGACTMIGAEDEVFKYIEPLIRDISAENGYLH
TGKNGSGHFAKMVHNGIEYGMMQAIGEGFEVLEKSQFDFDLKEVARVWSHGSVIRGWLMELMEKAFEKDPKLSGIKGVMH
SSGEGLWTVEEALNLKVPVPVIAQSLFMRYRSEQEDTFAGKVVAALRNEFGGHAVEKN

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=41.2371134020619, Blast_Score=172, Evalue=3e-43,
Organism=Escherichia coli, GI1788341, Length=314, Percent_Identity=36.9426751592357, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI145693186, Length=205, Percent_Identity=28.2926829268293, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786719, Length=272, Percent_Identity=27.5735294117647, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=40.6896551724138, Blast_Score=193, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=42.4137931034483, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321977, Length=298, Percent_Identity=42.2818791946309, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24639279, Length=288, Percent_Identity=39.9305555555556, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 33387; Mature: 33387

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLIGLGRMGFNLALNMRDHGHEVVVYNRSPEKIKEAEKEGIKGAYTIEDLVKNLERR
CCEEEEEECCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHC
RIIWLMVPAGDPVDEMIEKLVPLLEEHDIIIDGGNSYYKDTLRRYEMLKEKGIDFVDVGT
EEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCEEECCC
SGGIEGARHGACTMIGAEDEVFKYIEPLIRDISAENGYLHTGKNGSGHFAKMVHNGIEYG
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHH
MMQAIGEGFEVLEKSQFDFDLKEVARVWSHGSVIRGWLMELMEKAFEKDPKLSGIKGVMH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SSGEGLWTVEEALNLKVPVPVIAQSLFMRYRSEQEDTFAGKVVAALRNEFGGHAVEKN
CCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKVGLIGLGRMGFNLALNMRDHGHEVVVYNRSPEKIKEAEKEGIKGAYTIEDLVKNLERR
CCEEEEEECCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHC
RIIWLMVPAGDPVDEMIEKLVPLLEEHDIIIDGGNSYYKDTLRRYEMLKEKGIDFVDVGT
EEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCEEECCC
SGGIEGARHGACTMIGAEDEVFKYIEPLIRDISAENGYLHTGKNGSGHFAKMVHNGIEYG
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHH
MMQAIGEGFEVLEKSQFDFDLKEVARVWSHGSVIRGWLMELMEKAFEKDPKLSGIKGVMH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SSGEGLWTVEEALNLKVPVPVIAQSLFMRYRSEQEDTFAGKVVAALRNEFGGHAVEKN
CCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]