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The map label for this gene is pfpI [H]

Identifier: 167040018

GI number: 167040018

Start: 1418123

End: 1418629

Strand: Reverse

Name: pfpI [H]

Synonym: Teth514_1377

Alternate gene names: 167040018

Gene position: 1418629-1418123 (Counterclockwise)

Preceding gene: 167040043

Following gene: 167040009

Centisome position: 57.73

GC content: 33.93

Gene sequence:

>507_bases
ATGAAAAAAATTGCTATCTTAATTGAGAATATGTATGAAGAGCCAGAACTACTATATCCATACTATAGGCTCAAAGAAGA
GGGATATGAAGTACATTTAATAGGTCCAGAAAAAGACAAAGTATATACAGGAAAACATGGATATCCAATGAAAAGCACCC
ATGCTTCTAAAGATGTAAAAGCCGAAGATTACGATGCGGTAATAATCCCCGGCGGTTATTCACCTGATCATATGAGAAGA
TGTAATGACACTATTAATTTTGTCAAAGAAATGGACAAACTGCAAAAAACCATAGCAGCTATTTGCCATGGACCATGGAT
TATGGCTTCCGCCTGCAATTTAAAAGGAAAAAAAGTTACAAGCTTTTTCTCAATAAAAGATGATTTAATAAATGCAGGAG
CCCAGTATGTAGATGAAGAAGTAGTTGTAGATGGAAATTTAATAACCTCCAGAACTCCTAACGATTTAGTAGCTTTTGTA
AAAGCTATAATTGAAACGGTTAAATAA

Upstream 100 bases:

>100_bases
GAAACAATAGAGAATTTTGTTTACAATTTTAATTCTTGACATAGGTTGCCATAAATGTTATAATAATGTTAACTATAAAA
ATTCTAAGAGGTGAATTCTT

Downstream 100 bases:

>100_bases
TTATACTTTTTATTGCGAACCCCCTAATAAGTGACGGGGCTCGCAACTTATTATTTCACGATTAAATGTTATGAATCTAT
ATACTTTTCAAGGTAGCGAA

Product: PfpI family intracellular peptidase

Products: NA

Alternate protein names: Intracellular protease I [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MKKIAILIENMYEEPELLYPYYRLKEEGYEVHLIGPEKDKVYTGKHGYPMKSTHASKDVKAEDYDAVIIPGGYSPDHMRR
CNDTINFVKEMDKLQKTIAAICHGPWIMASACNLKGKKVTSFFSIKDDLINAGAQYVDEEVVVDGNLITSRTPNDLVAFV
KAIIETVK

Sequences:

>Translated_168_residues
MKKIAILIENMYEEPELLYPYYRLKEEGYEVHLIGPEKDKVYTGKHGYPMKSTHASKDVKAEDYDAVIIPGGYSPDHMRR
CNDTINFVKEMDKLQKTIAAICHGPWIMASACNLKGKKVTSFFSIKDDLINAGAQYVDEEVVVDGNLITSRTPNDLVAFV
KAIIETVK
>Mature_168_residues
MKKIAILIENMYEEPELLYPYYRLKEEGYEVHLIGPEKDKVYTGKHGYPMKSTHASKDVKAEDYDAVIIPGGYSPDHMRR
CNDTINFVKEMDKLQKTIAAICHGPWIMASACNLKGKKVTSFFSIKDDLINAGAQYVDEEVVVDGNLITSRTPNDLVAFV
KAIIETVK

Specific function: Highly stable protease. Although the physiological function is unclear it is the dominant protease in P.furiosus [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PfpI endopeptidase domain [H]

Homologues:

Organism=Escherichia coli, GI87082219, Length=160, Percent_Identity=40.625, Blast_Score=120, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17558714, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006286
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 18990; Mature: 18990

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAILIENMYEEPELLYPYYRLKEEGYEVHLIGPEKDKVYTGKHGYPMKSTHASKDVK
CCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
AEDYDAVIIPGGYSPDHMRRCNDTINFVKEMDKLQKTIAAICHGPWIMASACNLKGKKVT
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHH
SFFSIKDDLINAGAQYVDEEVVVDGNLITSRTPNDLVAFVKAIIETVK
HHHHHHHHHHHHHHHHCCCEEEECCCEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIAILIENMYEEPELLYPYYRLKEEGYEVHLIGPEKDKVYTGKHGYPMKSTHASKDVK
CCHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
AEDYDAVIIPGGYSPDHMRRCNDTINFVKEMDKLQKTIAAICHGPWIMASACNLKGKKVT
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHH
SFFSIKDDLINAGAQYVDEEVVVDGNLITSRTPNDLVAFVKAIIETVK
HHHHHHHHHHHHHHHHCCCEEEECCCEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626329 [H]