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The map label for this gene is napA [H]

Identifier: 167039963

GI number: 167039963

Start: 1359957

End: 1361105

Strand: Direct

Name: napA [H]

Synonym: Teth514_1320

Alternate gene names: 167039963

Gene position: 1359957-1361105 (Clockwise)

Preceding gene: 167039962

Following gene: 167039964

Centisome position: 55.34

GC content: 51.78

Gene sequence:

>1149_bases
GTGACCTTACTGGAACTTGCCATAATACTGGGAATATCCAGGATCGGCGGTTATCTGGCGGCAAGGTTCAACCAGATGAA
CGTACTGGGCCAGATCATCGCCGGCCTTCTCATAGGACCTTCGGTCTTCGGCTTGGTCCACTCCGATTATGTGCTGGAGT
TCATGGCCGAAATAGGTGTGGTCCTGCTAATGTTCCTGGCAGGCCTCGAGACCGACACGTCGGAACTTATAGCGTCAGGA
TTTTCGTCTACGGCCATCGCCGCCGGAGGGGTTATAGTGCCCTTCGCTGCAGGTGCTTGGGGCGGACTGGCTGCGGGTGT
TACCCTGCCCGAGGCCCTGTTCCTGGGGACCATGTTGACAGCCACCTCTGTCAGTATAACAGTGCAGGCACTGAGGGAAA
TGGGAAAGCTGAATTCAAAAGAGGGTATTGCCATTATGGCTGCTGCGGTAATCGACGACGTGATAGGTATAATCGTCCTC
ACCTTTGTGACCGGCTATATCTCCGGTGGAACCAGGATCCTGCCGCTGATGGAGAAAATAGGAGTATTTGCGGTCGCAGT
GGTAGTTATTACAGTCGTGCTTCGGAGATACGGTGAACGCATAATGGAATTAATGAGACCGGGAACCAGGATCATAACCT
TCGCCTTGGTACTATGCTTTAGCGTGGCTTACTTCGCCGAAAAGGCGGACATTGCCGCCATCACCGGTGCTTACATAGCG
GGCTTGATTCTTTCAAACTACAGTACAAAAGAAAAAATTGTCCGCGGCATAGAAGAAATAGCCTACCTTTTCTTCACGCC
CATATTTTTCATCAGCATCGGACTGAAGACTGATGTAAGGGCTGTGCTAGGCGATATCGGCTTCAGTCTTATCATAATAG
CCATTGCTGTGCTCGGCAAGATCATCGGCTGCGGGCTGACGGCAAGGCTCGTGGGATTCAACTGGAGTGAGGGCTTTACA
GTAGGCGCGGGCATGGTGCCCAGGGGAGAAGTGGCCCTGATCATCGCCAACCTGGGCTTGAAAAAGGGTATTGTTTCCCA
GAGGATTTTCGCTGTTTCGGTGCTGATGGTTCTTGTAACTACTCTTATTGCCCCGCCGCTTTTAAAGCTGTTTTTCCATA
GGGCAGAAAATACAGAAAACGGGGAGTGA

Upstream 100 bases:

>100_bases
CTCAAATTTTTTGCATTAATACCAGTGAAGACTATGAAAGAGCGCTGTTGTTGGAAAAGGATTCGATTCCGGTAAACCGA
TTTTTAAGGAGGGTTCACTC

Downstream 100 bases:

>100_bases
AGGCAATGTACCTGATCGTTATCATCCTTAACCGGCCAGAACTTTTAAAAAAGCTCCTGACGGTAATGAAAAGGAACGGG
GCCAAGGGGGCCACGGTGCT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTLLELAIILGISRIGGYLAARFNQMNVLGQIIAGLLIGPSVFGLVHSDYVLEFMAEIGVVLLMFLAGLETDTSELIASG
FSSTAIAAGGVIVPFAAGAWGGLAAGVTLPEALFLGTMLTATSVSITVQALREMGKLNSKEGIAIMAAAVIDDVIGIIVL
TFVTGYISGGTRILPLMEKIGVFAVAVVVITVVLRRYGERIMELMRPGTRIITFALVLCFSVAYFAEKADIAAITGAYIA
GLILSNYSTKEKIVRGIEEIAYLFFTPIFFISIGLKTDVRAVLGDIGFSLIIIAIAVLGKIIGCGLTARLVGFNWSEGFT
VGAGMVPRGEVALIIANLGLKKGIVSQRIFAVSVLMVLVTTLIAPPLLKLFFHRAENTENGE

Sequences:

>Translated_382_residues
MTLLELAIILGISRIGGYLAARFNQMNVLGQIIAGLLIGPSVFGLVHSDYVLEFMAEIGVVLLMFLAGLETDTSELIASG
FSSTAIAAGGVIVPFAAGAWGGLAAGVTLPEALFLGTMLTATSVSITVQALREMGKLNSKEGIAIMAAAVIDDVIGIIVL
TFVTGYISGGTRILPLMEKIGVFAVAVVVITVVLRRYGERIMELMRPGTRIITFALVLCFSVAYFAEKADIAAITGAYIA
GLILSNYSTKEKIVRGIEEIAYLFFTPIFFISIGLKTDVRAVLGDIGFSLIIIAIAVLGKIIGCGLTARLVGFNWSEGFT
VGAGMVPRGEVALIIANLGLKKGIVSQRIFAVSVLMVLVTTLIAPPLLKLFFHRAENTENGE
>Mature_381_residues
TLLELAIILGISRIGGYLAARFNQMNVLGQIIAGLLIGPSVFGLVHSDYVLEFMAEIGVVLLMFLAGLETDTSELIASGF
SSTAIAAGGVIVPFAAGAWGGLAAGVTLPEALFLGTMLTATSVSITVQALREMGKLNSKEGIAIMAAAVIDDVIGIIVLT
FVTGYISGGTRILPLMEKIGVFAVAVVVITVVLRRYGERIMELMRPGTRIITFALVLCFSVAYFAEKADIAAITGAYIAG
LILSNYSTKEKIVRGIEEIAYLFFTPIFFISIGLKTDVRAVLGDIGFSLIIIAIAVLGKIIGCGLTARLVGFNWSEGFTV
GAGMVPRGEVALIIANLGLKKGIVSQRIFAVSVLMVLVTTLIAPPLLKLFFHRAENTENGE

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=347, Percent_Identity=26.8011527377522, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786232, Length=315, Percent_Identity=27.3015873015873, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789749, Length=365, Percent_Identity=27.1232876712329, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=381, Percent_Identity=28.0839895013123, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 40325; Mature: 40194

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00409 PROKAR_NTER_METHYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLELAIILGISRIGGYLAARFNQMNVLGQIIAGLLIGPSVFGLVHSDYVLEFMAEIGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLMFLAGLETDTSELIASGFSSTAIAAGGVIVPFAAGAWGGLAAGVTLPEALFLGTMLT
HHHHHHHCCCCCHHHHHHCCCCCHHHHCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHH
ATSVSITVQALREMGKLNSKEGIAIMAAAVIDDVIGIIVLTFVTGYISGGTRILPLMEKI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVFAVAVVVITVVLRRYGERIMELMRPGTRIITFALVLCFSVAYFAEKADIAAITGAYIA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLILSNYSTKEKIVRGIEEIAYLFFTPIFFISIGLKTDVRAVLGDIGFSLIIIAIAVLGK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIGCGLTARLVGFNWSEGFTVGAGMVPRGEVALIIANLGLKKGIVSQRIFAVSVLMVLVT
HHHCCHHHHHHCCCCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
TLIAPPLLKLFFHRAENTENGE
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLLELAIILGISRIGGYLAARFNQMNVLGQIIAGLLIGPSVFGLVHSDYVLEFMAEIGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLLMFLAGLETDTSELIASGFSSTAIAAGGVIVPFAAGAWGGLAAGVTLPEALFLGTMLT
HHHHHHHCCCCCHHHHHHCCCCCHHHHCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHH
ATSVSITVQALREMGKLNSKEGIAIMAAAVIDDVIGIIVLTFVTGYISGGTRILPLMEKI
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GVFAVAVVVITVVLRRYGERIMELMRPGTRIITFALVLCFSVAYFAEKADIAAITGAYIA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLILSNYSTKEKIVRGIEEIAYLFFTPIFFISIGLKTDVRAVLGDIGFSLIIIAIAVLGK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIGCGLTARLVGFNWSEGFTVGAGMVPRGEVALIIANLGLKKGIVSQRIFAVSVLMVLVT
HHHCCHHHHHHCCCCCCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
TLIAPPLLKLFFHRAENTENGE
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]