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The map label for this gene is serA [H]

Identifier: 167039730

GI number: 167039730

Start: 1116466

End: 1117047

Strand: Direct

Name: serA [H]

Synonym: Teth514_1080

Alternate gene names: 167039730

Gene position: 1116466-1117047 (Clockwise)

Preceding gene: 167039729

Following gene: 167039731

Centisome position: 45.44

GC content: 36.08

Gene sequence:

>582_bases
ATGGGTGTTAAAATTGCTATTGTAAATTCCAGTAGTTTTGGTAAGCATTTTCCTGAACATATCGAAAGGTTAAAAGCGTT
AGGAGAAGTAGAAAGATTTGAACTTCCCCACGATATAAGAGGGAAGGCTTTAGCAGAAAAGCTAATGGGCTATTCTGTAA
TAATTGCCAGTGTCAAGCCATATTACGATAAGGAGTTTTTTGAGCATAAAGATAAAACTCTTTTAATAACACGCCACGGC
ATAGGTTATGATACAATAGACATTAAAAGCGCTACTGAAAAGGGAGTTATTGTAACGAAAGTTGAAGGCATTGTAGAAAG
GGAAGCTGTAGCCGAAAATGCTGTTGCACTTTTATTAGATGTTATGAAAAAAGTAAGGTCTGCATCCCTTAAAGTGAAAG
AAGGAAAGTGGGAGGAAAGAGCGAGCTTCATTGGATATGAGATAAAAGACAAAGTTGCAGGAATTATAGGTATTGGAAAT
ATTGGAAGCAGAGTTTGTGAAATTCTGAAATATGGGTTTGGTGCTAAAGTAGTGGCTTATGACCCTAATCTTTCACCTGA
AAACTTTGACAAAAGAACTTAA

Upstream 100 bases:

>100_bases
GAGAACAAAACAAAGAGATAGTAGAGGAATTAAAAAATTATGTAAAGATTGAAGTGGTATAGAAAATTTAAAAGGAGAAG
ATTACTTAGGAGGCGTAAAA

Downstream 100 bases:

>100_bases
AAAATTATTTGAACTGCACACTAAATTATAAAAAACGAGGAGGTAATTAGATGAAAGACATTGGATTAATTGGATTGGCA
GTAATGGGACAAAATCTTGC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDIRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHG
IGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAVALLLDVMKKVRSASLKVKEGKWEERASFIGYEIKDKVAGIIGIGN
IGSRVCEILKYGFGAKVVAYDPNLSPENFDKRT

Sequences:

>Translated_193_residues
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDIRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHG
IGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAVALLLDVMKKVRSASLKVKEGKWEERASFIGYEIKDKVAGIIGIGN
IGSRVCEILKYGFGAKVVAYDPNLSPENFDKRT
>Mature_192_residues
GVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDIRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHGI
GYDTIDIKSATEKGVIVTKVEGIVEREAVAENAVALLLDVMKKVRSASLKVKEGKWEERASFIGYEIKDKVAGIIGIGNI
GSRVCEILKYGFGAKVVAYDPNLSPENFDKRT

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=117, Percent_Identity=35.042735042735, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1787645, Length=115, Percent_Identity=29.5652173913043, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=142, Percent_Identity=30.2816901408451, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 21483; Mature: 21352

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDIRGKALAEKLMGYSVIIASVKP
CCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCHHEEEECCCC
YYDKEFFEHKDKTLLITRHGIGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAVALLLD
CHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
VMKKVRSASLKVKEGKWEERASFIGYEIKDKVAGIIGIGNIGSRVCEILKYGFGAKVVAY
HHHHHHHHCEEECCCCHHHHHHHCCEEHHHHHEEEEEECHHHHHHHHHHHHCCCCEEEEE
DPNLSPENFDKRT
CCCCCCCCCCCCC
>Mature Secondary Structure 
GVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDIRGKALAEKLMGYSVIIASVKP
CEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCHHEEEECCCC
YYDKEFFEHKDKTLLITRHGIGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAVALLLD
CHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
VMKKVRSASLKVKEGKWEERASFIGYEIKDKVAGIIGIGNIGSRVCEILKYGFGAKVVAY
HHHHHHHHCEEECCCCHHHHHHHCCEEHHHHHEEEEEECHHHHHHHHHHHHCCCCEEEEE
DPNLSPENFDKRT
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]