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The map label for this gene is gyaR [H]

Identifier: 167039728

GI number: 167039728

Start: 1114459

End: 1115430

Strand: Direct

Name: gyaR [H]

Synonym: Teth514_1078

Alternate gene names: 167039728

Gene position: 1114459-1115430 (Clockwise)

Preceding gene: 167039727

Following gene: 167039729

Centisome position: 45.35

GC content: 36.63

Gene sequence:

>972_bases
ATGTTTAAAGTGTATGTTACAAGGATGATTCCTGAGGAAGGGATTGAACTTTTAAAAAAGTACTGCGAAGTTGAAATAAA
CCCAGAAGACAGACCTCTTAAAAGAGAAGAATTGCTTGATGTAATAAAAGACAAAGATGCCGTTGTGACGCAGCTTAATG
AAAAAGTTGATGCAGAATTTTTTGATTCAGCAAAAAATTTAAAAATTGTGGCAAATTACGCTGTAGGATTTGACAATATC
GATCTAAAAGAGGCAACTAAGAGAAAAATTTATGTTACAAATACGCCAGATGTTTTGACAAATGCAACAGCAGAACTTGC
ATGGGCACTCCTCTTTGCAGCAGCTCGAAGGGTTGTTGAGGCAGATAAATTCACAAGAGAAGGAAAATTTACTGGATGGG
CACCGAACCTCTTTTTAGGTAAAGCTGTGACGGGAAAAACATTGGGAGTAATTGGTGCGGGGCGTATAGGACAAGCTTTC
GCAAAGATGTCGAAAGGGTTTGACATGAAAATTTTATACACTGCAAACACTCCAAAAGAAGAATTTGAAAAAGAGACAGG
TGCAAAGTATGTTGACTTGGAAACACTTTTGAAAGAATCGGATTTTGTATCACTTCATGTTCCGCTGACACCTCATACAC
GCCATTTAATAGGGGAAAAAGAATTAAAACTTATGAAAAAAACCGCAATTTTAATAAATACAGCGAGAGGTCCTGTTGTA
GATGAAAAAGCGCTGGTAAATGCATTAAAAAATAAAGACATTTATGCAGCAGGTCTTGACGTATATGAAAAAGAACCGGA
GATTACAGAGGAATTAAAAACTTTAGATAATGTAGTAATACTTCCACATATAGGAAGTGCTACAGATGAGGCAAGGAGAG
ATATGGCAGTACTTGTTGCACAAAATATAATAGACGTAATAGAAGGAAGAACGCCGCGCACCCTTGTAAATAAAGACATA
TTGGAGAAGTAA

Upstream 100 bases:

>100_bases
TTTGTCTCTATAAGTGTATTTTTGACAAATATTTTGTCTTTTATAACAATATCTGTTATACTATACTTGATGGGATAAAT
TTGTATGGAGGAGGATTCTT

Downstream 100 bases:

>100_bases
ATTTTTAAGGAATCCCTAAAATGGGATTCCTTACTTTGTTCTTATAAAACCATACAAACTAATAAAAAAATTTTAAAACA
AAGAAGGATTTTTTGGATTT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MFKVYVTRMIPEEGIELLKKYCEVEINPEDRPLKREELLDVIKDKDAVVTQLNEKVDAEFFDSAKNLKIVANYAVGFDNI
DLKEATKRKIYVTNTPDVLTNATAELAWALLFAAARRVVEADKFTREGKFTGWAPNLFLGKAVTGKTLGVIGAGRIGQAF
AKMSKGFDMKILYTANTPKEEFEKETGAKYVDLETLLKESDFVSLHVPLTPHTRHLIGEKELKLMKKTAILINTARGPVV
DEKALVNALKNKDIYAAGLDVYEKEPEITEELKTLDNVVILPHIGSATDEARRDMAVLVAQNIIDVIEGRTPRTLVNKDI
LEK

Sequences:

>Translated_323_residues
MFKVYVTRMIPEEGIELLKKYCEVEINPEDRPLKREELLDVIKDKDAVVTQLNEKVDAEFFDSAKNLKIVANYAVGFDNI
DLKEATKRKIYVTNTPDVLTNATAELAWALLFAAARRVVEADKFTREGKFTGWAPNLFLGKAVTGKTLGVIGAGRIGQAF
AKMSKGFDMKILYTANTPKEEFEKETGAKYVDLETLLKESDFVSLHVPLTPHTRHLIGEKELKLMKKTAILINTARGPVV
DEKALVNALKNKDIYAAGLDVYEKEPEITEELKTLDNVVILPHIGSATDEARRDMAVLVAQNIIDVIEGRTPRTLVNKDI
LEK
>Mature_323_residues
MFKVYVTRMIPEEGIELLKKYCEVEINPEDRPLKREELLDVIKDKDAVVTQLNEKVDAEFFDSAKNLKIVANYAVGFDNI
DLKEATKRKIYVTNTPDVLTNATAELAWALLFAAARRVVEADKFTREGKFTGWAPNLFLGKAVTGKTLGVIGAGRIGQAF
AKMSKGFDMKILYTANTPKEEFEKETGAKYVDLETLLKESDFVSLHVPLTPHTRHLIGEKELKLMKKTAILINTARGPVV
DEKALVNALKNKDIYAAGLDVYEKEPEITEELKTLDNVVILPHIGSATDEARRDMAVLVAQNIIDVIEGRTPRTLVNKDI
LEK

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=314, Percent_Identity=41.7197452229299, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI23308577, Length=293, Percent_Identity=32.4232081911263, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI61743967, Length=290, Percent_Identity=36.2068965517241, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4557497, Length=302, Percent_Identity=36.0927152317881, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI145580578, Length=302, Percent_Identity=34.1059602649007, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI4557499, Length=302, Percent_Identity=34.1059602649007, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI145580575, Length=295, Percent_Identity=34.5762711864407, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=39.375, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787645, Length=265, Percent_Identity=35.4716981132075, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=30.8411214953271, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788660, Length=261, Percent_Identity=27.2030651340996, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=321, Percent_Identity=33.6448598130841, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=30.1470588235294, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=39.1666666666667, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=33.0960854092527, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=291, Percent_Identity=31.2714776632302, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321253, Length=283, Percent_Identity=28.6219081272085, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=302, Percent_Identity=27.1523178807947, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=210, Percent_Identity=29.5238095238095, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=45.9807073954984, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=43.1309904153355, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=43.1309904153355, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=43.1309904153355, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=43.1309904153355, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=43.1309904153355, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=40.8945686900958, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=34.5047923322684, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19921140, Length=328, Percent_Identity=32.6219512195122, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646446, Length=267, Percent_Identity=36.3295880149813, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646448, Length=267, Percent_Identity=36.3295880149813, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646452, Length=267, Percent_Identity=36.3295880149813, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646450, Length=267, Percent_Identity=36.3295880149813, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62472511, Length=290, Percent_Identity=35.5172413793103, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36161; Mature: 36161

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKVYVTRMIPEEGIELLKKYCEVEINPEDRPLKREELLDVIKDKDAVVTQLNEKVDAEF
CEEEEEEECCCHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCHHH
FDSAKNLKIVANYAVGFDNIDLKEATKRKIYVTNTPDVLTNATAELAWALLFAAARRVVE
HCCCCCEEEEEEEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
ADKFTREGKFTGWAPNLFLGKAVTGKTLGVIGAGRIGQAFAKMSKGFDMKILYTANTPKE
HHHHHCCCCCCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCHH
EFEKETGAKYVDLETLLKESDFVSLHVPLTPHTRHLIGEKELKLMKKTAILINTARGPVV
HHHHHHCCEEEEHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHHHEEEEECCCCCCC
DEKALVNALKNKDIYAAGLDVYEKEPEITEELKTLDNVVILPHIGSATDEARRDMAVLVA
CHHHHHHHHHCCCEEEECCCHHCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
QNIIDVIEGRTPRTLVNKDILEK
HHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MFKVYVTRMIPEEGIELLKKYCEVEINPEDRPLKREELLDVIKDKDAVVTQLNEKVDAEF
CEEEEEEECCCHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCHHH
FDSAKNLKIVANYAVGFDNIDLKEATKRKIYVTNTPDVLTNATAELAWALLFAAARRVVE
HCCCCCEEEEEEEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
ADKFTREGKFTGWAPNLFLGKAVTGKTLGVIGAGRIGQAFAKMSKGFDMKILYTANTPKE
HHHHHCCCCCCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCHH
EFEKETGAKYVDLETLLKESDFVSLHVPLTPHTRHLIGEKELKLMKKTAILINTARGPVV
HHHHHHCCEEEEHHHHHCCCCEEEEEECCCCCHHHHHCHHHHHHHHHHEEEEECCCCCCC
DEKALVNALKNKDIYAAGLDVYEKEPEITEELKTLDNVVILPHIGSATDEARRDMAVLVA
CHHHHHHHHHCCCEEEECCCHHCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
QNIIDVIEGRTPRTLVNKDILEK
HHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA