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The map label for this gene is uvrC [H]

Identifier: 167039707

GI number: 167039707

Start: 1093768

End: 1095615

Strand: Direct

Name: uvrC [H]

Synonym: Teth514_1057

Alternate gene names: 167039707

Gene position: 1093768-1095615 (Clockwise)

Preceding gene: 167039706

Following gene: 167039709

Centisome position: 44.51

GC content: 35.39

Gene sequence:

>1848_bases
ATGACCATAGAAGAAAAATTAAAGCTTTTGCCTGAAAAACCTGGCGTTTATATAATGAAAGATAAAAGTGGCAAAATAAT
TTATGTAGGTAAAGCGGTAGTTCTCAAAAACAGAGTGAGGCAGTATTTTCAAAATAAAGAAAAACAATTGCCAAAAGTAA
AAGTAATGCTTTCTCATGTAGAAGACTTTGAGTACATTGTTACTGATACTGAACTTGAAGCTTTAATGTTGGAATGCAAC
TTAATTAAAAAGTATAAGCCTAAGTATAATGTATTATTAAAAGATGACAAAAATTACCCCTATATTAAAGTTACAGTAAA
TGAAGAGTATCCCCGCATAATGTTTACGAGAAGGATTGAACCCGATGGGGCGAAATACTTCGGACCTTATAGCAGTGCCT
TTGCAGTGAGGGAGACTATAAAACTTGTCAGAAAAATGTTTCCAATAAGAACATGTAACAAAAATATTGAAAAGGACATG
GGTAAGGTTAGAGAATGTCTCTATTACCACATAGGATTGTGTTCTGCCCCTTGTACTAACAAAATAAATAAAGAAGATTA
TATAAAATTAGTTGATCAGGCAGTTCTCTTTCTTGATGGAAAGAGGGATTGGCTCATACAAAAACTTAAAGAAGATATGA
AAAAAGCGGCGGAAGAATTGAGGTTCGAGGAAGCGGCGAGGATTAGAGACCAGATTTTTGCTATTGAAAGGACATCAGAA
AAACAAAAGGTGGTATCAGTAGGAGAAGATGAGCAGGATATAATTTCAATGGCCCGAAGTGCGGATATTTCCTGCATACA
GGTGTTCTTTGTACGAGACGGAAAATTAAGCGGAAGAGAGCATTATTATATGAAAAATACAGAAGGGATGGAAAGAGGAG
AAATAATCTCTTCTTTTATAAAGCAATTTTATGAAGGTGCTCCTTACATTCCCAAAGAAATAATAACTGATGTGGAATTA
GACGAAAGTGAGCTTCTCAGTGAATGGTTATCACAAAAGAGAGGCAATAAAGTTTTTATAACCATTCCTGTTAGAGGTAA
GAAAAAAGAGCTTGTGGATATGGTTTATCAAAATGCTTTAGAAGCCCTTAAGAATGACATATCAATAAGAGAGGAAATTT
CAAAAGACCAGGTTGTATTAGAACTTTCTAATTTAGTGGGACTTGACTACGCCAAGAGGATTGAAGCCTATGATATTTCA
AACACAAGAGGTCAAGACAATGTAGGGTCTATGGTGGTGTTTGTAGATGGAAAGCCCAAGAAAAGTCAGTACAGAAAGTT
TAACATAAAATATGTAGAGGGACAAGACGATTATGAGAGTATGAGAGAGGTAATAGAAAGGCGTTTTTTACATGCCATTG
AAGAAAAAGAGCTTATTGAAAAAGGTGAACTTGAAGAGGATAAGGCCAAATTTGCTGAAATGCCAGATTTAATATTTGTA
GATGGTGGCATAGGGCATGTAAATGCTGTACTGCAGGTGTTAAGTGGCTTGGGGATTTCTATTCCTGTTTATGGTATGGT
AAAAGATTCAAAACACAGGACTCGAGGCCTTGTATCACCTCAAGGTGAAATTGACATACCTATGACTACAAAAGCTTTTC
GCCTGATTGCTCAAATACAAGAAGAAGCTCATAGATTTGCCATAACTTTCCACAAAGAAAAGCAAAGTAAGAGATTTAAA
AGCGAACTTCTCAATATCCCCGGCATAGGAAAAAAGAGGGCAAAAGCTTTATATGATGCCTTCAAATCCATAGAAGAAAT
AAAAAGGGCAAGTGTGGAGGACCTTAAAAAAGTGGAAGGAATGAATGAAAAAGCTGCTCAAGCTGTATATGAATATTTTA
GGAAATAA

Upstream 100 bases:

>100_bases
TAATAGTTGAAAATGGCGGTGAAGGTGGGAAAGTAGCAGCACCTATAGCGAGAGATATAATAAGAGCTTATTTAACTAAA
TGACCTGAAGGTGATGGATA

Downstream 100 bases:

>100_bases
AAAGCGTCAAGATTTTGTCTTGACGCTTCAGACTATAGACAAACTTTCGTAAAGGAGATATTTTGCATAAGGAGCGACTT
GTTACAAAGCGATAACAAAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTIEEKLKLLPEKPGVYIMKDKSGKIIYVGKAVVLKNRVRQYFQNKEKQLPKVKVMLSHVEDFEYIVTDTELEALMLECN
LIKKYKPKYNVLLKDDKNYPYIKVTVNEEYPRIMFTRRIEPDGAKYFGPYSSAFAVRETIKLVRKMFPIRTCNKNIEKDM
GKVRECLYYHIGLCSAPCTNKINKEDYIKLVDQAVLFLDGKRDWLIQKLKEDMKKAAEELRFEEAARIRDQIFAIERTSE
KQKVVSVGEDEQDIISMARSADISCIQVFFVRDGKLSGREHYYMKNTEGMERGEIISSFIKQFYEGAPYIPKEIITDVEL
DESELLSEWLSQKRGNKVFITIPVRGKKKELVDMVYQNALEALKNDISIREEISKDQVVLELSNLVGLDYAKRIEAYDIS
NTRGQDNVGSMVVFVDGKPKKSQYRKFNIKYVEGQDDYESMREVIERRFLHAIEEKELIEKGELEEDKAKFAEMPDLIFV
DGGIGHVNAVLQVLSGLGISIPVYGMVKDSKHRTRGLVSPQGEIDIPMTTKAFRLIAQIQEEAHRFAITFHKEKQSKRFK
SELLNIPGIGKKRAKALYDAFKSIEEIKRASVEDLKKVEGMNEKAAQAVYEYFRK

Sequences:

>Translated_615_residues
MTIEEKLKLLPEKPGVYIMKDKSGKIIYVGKAVVLKNRVRQYFQNKEKQLPKVKVMLSHVEDFEYIVTDTELEALMLECN
LIKKYKPKYNVLLKDDKNYPYIKVTVNEEYPRIMFTRRIEPDGAKYFGPYSSAFAVRETIKLVRKMFPIRTCNKNIEKDM
GKVRECLYYHIGLCSAPCTNKINKEDYIKLVDQAVLFLDGKRDWLIQKLKEDMKKAAEELRFEEAARIRDQIFAIERTSE
KQKVVSVGEDEQDIISMARSADISCIQVFFVRDGKLSGREHYYMKNTEGMERGEIISSFIKQFYEGAPYIPKEIITDVEL
DESELLSEWLSQKRGNKVFITIPVRGKKKELVDMVYQNALEALKNDISIREEISKDQVVLELSNLVGLDYAKRIEAYDIS
NTRGQDNVGSMVVFVDGKPKKSQYRKFNIKYVEGQDDYESMREVIERRFLHAIEEKELIEKGELEEDKAKFAEMPDLIFV
DGGIGHVNAVLQVLSGLGISIPVYGMVKDSKHRTRGLVSPQGEIDIPMTTKAFRLIAQIQEEAHRFAITFHKEKQSKRFK
SELLNIPGIGKKRAKALYDAFKSIEEIKRASVEDLKKVEGMNEKAAQAVYEYFRK
>Mature_614_residues
TIEEKLKLLPEKPGVYIMKDKSGKIIYVGKAVVLKNRVRQYFQNKEKQLPKVKVMLSHVEDFEYIVTDTELEALMLECNL
IKKYKPKYNVLLKDDKNYPYIKVTVNEEYPRIMFTRRIEPDGAKYFGPYSSAFAVRETIKLVRKMFPIRTCNKNIEKDMG
KVRECLYYHIGLCSAPCTNKINKEDYIKLVDQAVLFLDGKRDWLIQKLKEDMKKAAEELRFEEAARIRDQIFAIERTSEK
QKVVSVGEDEQDIISMARSADISCIQVFFVRDGKLSGREHYYMKNTEGMERGEIISSFIKQFYEGAPYIPKEIITDVELD
ESELLSEWLSQKRGNKVFITIPVRGKKKELVDMVYQNALEALKNDISIREEISKDQVVLELSNLVGLDYAKRIEAYDISN
TRGQDNVGSMVVFVDGKPKKSQYRKFNIKYVEGQDDYESMREVIERRFLHAIEEKELIEKGELEEDKAKFAEMPDLIFVD
GGIGHVNAVLQVLSGLGISIPVYGMVKDSKHRTRGLVSPQGEIDIPMTTKAFRLIAQIQEEAHRFAITFHKEKQSKRFKS
ELLNIPGIGKKRAKALYDAFKSIEEIKRASVEDLKKVEGMNEKAAQAVYEYFRK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=618, Percent_Identity=35.5987055016181, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71244; Mature: 71113

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEEKLKLLPEKPGVYIMKDKSGKIIYVGKAVVLKNRVRQYFQNKEKQLPKVKVMLSHV
CCHHHHHHHCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EDFEYIVTDTELEALMLECNLIKKYKPKYNVLLKDDKNYPYIKVTVNEEYPRIMFTRRIE
CCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEECC
PDGAKYFGPYSSAFAVRETIKLVRKMFPIRTCNKNIEKDMGKVRECLYYHIGLCSAPCTN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
KINKEDYIKLVDQAVLFLDGKRDWLIQKLKEDMKKAAEELRFEEAARIRDQIFAIERTSE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQKVVSVGEDEQDIISMARSADISCIQVFFVRDGKLSGREHYYMKNTEGMERGEIISSFI
HHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHH
KQFYEGAPYIPKEIITDVELDESELLSEWLSQKRGNKVFITIPVRGKKKELVDMVYQNAL
HHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALKNDISIREEISKDQVVLELSNLVGLDYAKRIEAYDISNTRGQDNVGSMVVFVDGKPK
HHHHHCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCCCCCEEEEECCCCC
KSQYRKFNIKYVEGQDDYESMREVIERRFLHAIEEKELIEKGELEEDKAKFAEMPDLIFV
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
DGGIGHVNAVLQVLSGLGISIPVYGMVKDSKHRTRGLVSPQGEIDIPMTTKAFRLIAQIQ
ECCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
EEAHRFAITFHKEKQSKRFKSELLNIPGIGKKRAKALYDAFKSIEEIKRASVEDLKKVEG
HHHHHEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
MNEKAAQAVYEYFRK
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
TIEEKLKLLPEKPGVYIMKDKSGKIIYVGKAVVLKNRVRQYFQNKEKQLPKVKVMLSHV
CHHHHHHHCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EDFEYIVTDTELEALMLECNLIKKYKPKYNVLLKDDKNYPYIKVTVNEEYPRIMFTRRIE
CCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEECC
PDGAKYFGPYSSAFAVRETIKLVRKMFPIRTCNKNIEKDMGKVRECLYYHIGLCSAPCTN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
KINKEDYIKLVDQAVLFLDGKRDWLIQKLKEDMKKAAEELRFEEAARIRDQIFAIERTSE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQKVVSVGEDEQDIISMARSADISCIQVFFVRDGKLSGREHYYMKNTEGMERGEIISSFI
HHHHHHCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHH
KQFYEGAPYIPKEIITDVELDESELLSEWLSQKRGNKVFITIPVRGKKKELVDMVYQNAL
HHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALKNDISIREEISKDQVVLELSNLVGLDYAKRIEAYDISNTRGQDNVGSMVVFVDGKPK
HHHHHCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCCCCCEEEEECCCCC
KSQYRKFNIKYVEGQDDYESMREVIERRFLHAIEEKELIEKGELEEDKAKFAEMPDLIFV
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
DGGIGHVNAVLQVLSGLGISIPVYGMVKDSKHRTRGLVSPQGEIDIPMTTKAFRLIAQIQ
ECCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
EEAHRFAITFHKEKQSKRFKSELLNIPGIGKKRAKALYDAFKSIEEIKRASVEDLKKVEG
HHHHHEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
MNEKAAQAVYEYFRK
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA