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The map label for this gene is pbpA [H]

Identifier: 167039706

GI number: 167039706

Start: 1092329

End: 1093750

Strand: Direct

Name: pbpA [H]

Synonym: Teth514_1056

Alternate gene names: 167039706

Gene position: 1092329-1093750 (Clockwise)

Preceding gene: 167039705

Following gene: 167039707

Centisome position: 44.45

GC content: 36.08

Gene sequence:

>1422_bases
ATGTCCAACTTAAATCGCAATATTAAAATTCTGTTTTGGTTTTTTTCTGTACTTTTTTTCGGCCTAATTGCCTATTTAAC
TTATTTCCAAATATATGAAAGAGATAAATTAATTACTAGTTCTTATAGTGTTTACAATCGAAGACTTATAGAACAGGAAA
AAAAGATATTGCGAGGTAGTATTTTGGACAGAAATGGGATTGTGCTTGCAAAAAGCGTGCAGGTAGATGGTTTACAAAAA
AGGGAATATCTAGATGGACCTGCTTTTGCCCATGTGATAGGATACAGCCGTAGAATATACCAGCAAGGAAACACAGGGAT
AGAAAAAGCCTATGATAGGGAACTACTTGGAATGGTAGGAAATGACCCGATGATTCTTTTGAGGAAATTAATTTTTGGAA
AAGGACAAATGGGGAATAATGTTTATTTAACAATAGATAAAACATTACAAGATATTGCTTATAAGGATATGGAGGGTAAA
AAAGGAGCGGTTGTGGCTTTAAATCCAAAGACTGGTGAAATTTTAGCGATGGTTTCTACACCTTCTTATGACCCCAATAC
TTTAGGAGAGAATTGGGAAGAAATAATGACAAGTTCTGAGCACGTAGTTTTAAATAGAGCTACGCAAGGTTTGTATCCTC
CAGGGTCTGTCTTTAAAATTGTAACTACCGCAGCAGTTTTGACATATAACCCTGAGTTATATGACAAGACTTTTTATTGT
AAAGGATATATAATTGTAGATGGTAATAGAATAAATAATTTTGGAGGTATTGCTCACGGAATAGAAGATTTTAAACAAGC
TTTTTATAGGTCTTGCAACTCCTTTTTTATACAGGCTGGTTTGGATTTAGGAAGTGAAAATTTGCAAACAATAGCTTATG
CTTTTGGACTAGATAAACGAGTTCCTTTAGAGATAGATACAACAAAAAATCAATTTCCTCCTATTGATGGGAAGTCTGAT
TTAGCTGAGACTTCTATAGGGCAAGGGAAAATGCTTGTGACACCTCTTACAATGGCCTTAGTTGCTTCTGCCGTTGCAAA
TGATGGGGTTATAATGAAACCCTATTTGATGAAATATGTAGCAGATCCTATTTCAGGGGCTGTCATTGAAAAAAGCACTC
CTTCACAGTATTTAAATCCTATATCAAAAAAGGTGGCAGATGCTATTAAACAATTGATGATAGGCGCAGTTAACGATAAA
GAGGGGACAGGTAAAGCTGCACAAATTCCTGGTATTACAGTTGCAGGCAAAACTGGGACTGCAGAAAATCCTCACGGTGA
TCCTCATGCGTGGTTTGTAGGTTTTGCCCCTGCAGAAAACCCACAGATAGTTGTAAGTGTAATAGTTGAAAATGGCGGTG
AAGGTGGGAAAGTAGCAGCACCTATAGCGAGAGATATAATAAGAGCTTATTTAACTAAATGA

Upstream 100 bases:

>100_bases
GTAACCCTTCCCTTTGTAAGTTATGGCGGTAGTTCTATGGTGACGAGCTTTGTGACATTGGGCATGCTCAATGGCATAGC
TCTTAAGGAGGAGCAACAGG

Downstream 100 bases:

>100_bases
CCTGAAGGTGATGGATAATGACCATAGAAGAAAAATTAAAGCTTTTGCCTGAAAAACCTGGCGTTTATATAATGAAAGAT
AAAAGTGGCAAAATAATTTA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSNLNRNIKILFWFFSVLFFGLIAYLTYFQIYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVQVDGLQK
REYLDGPAFAHVIGYSRRIYQQGNTGIEKAYDRELLGMVGNDPMILLRKLIFGKGQMGNNVYLTIDKTLQDIAYKDMEGK
KGAVVALNPKTGEILAMVSTPSYDPNTLGENWEEIMTSSEHVVLNRATQGLYPPGSVFKIVTTAAVLTYNPELYDKTFYC
KGYIIVDGNRINNFGGIAHGIEDFKQAFYRSCNSFFIQAGLDLGSENLQTIAYAFGLDKRVPLEIDTTKNQFPPIDGKSD
LAETSIGQGKMLVTPLTMALVASAVANDGVIMKPYLMKYVADPISGAVIEKSTPSQYLNPISKKVADAIKQLMIGAVNDK
EGTGKAAQIPGITVAGKTGTAENPHGDPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRAYLTK

Sequences:

>Translated_473_residues
MSNLNRNIKILFWFFSVLFFGLIAYLTYFQIYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVQVDGLQK
REYLDGPAFAHVIGYSRRIYQQGNTGIEKAYDRELLGMVGNDPMILLRKLIFGKGQMGNNVYLTIDKTLQDIAYKDMEGK
KGAVVALNPKTGEILAMVSTPSYDPNTLGENWEEIMTSSEHVVLNRATQGLYPPGSVFKIVTTAAVLTYNPELYDKTFYC
KGYIIVDGNRINNFGGIAHGIEDFKQAFYRSCNSFFIQAGLDLGSENLQTIAYAFGLDKRVPLEIDTTKNQFPPIDGKSD
LAETSIGQGKMLVTPLTMALVASAVANDGVIMKPYLMKYVADPISGAVIEKSTPSQYLNPISKKVADAIKQLMIGAVNDK
EGTGKAAQIPGITVAGKTGTAENPHGDPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRAYLTK
>Mature_472_residues
SNLNRNIKILFWFFSVLFFGLIAYLTYFQIYERDKLITSSYSVYNRRLIEQEKKILRGSILDRNGIVLAKSVQVDGLQKR
EYLDGPAFAHVIGYSRRIYQQGNTGIEKAYDRELLGMVGNDPMILLRKLIFGKGQMGNNVYLTIDKTLQDIAYKDMEGKK
GAVVALNPKTGEILAMVSTPSYDPNTLGENWEEIMTSSEHVVLNRATQGLYPPGSVFKIVTTAAVLTYNPELYDKTFYCK
GYIIVDGNRINNFGGIAHGIEDFKQAFYRSCNSFFIQAGLDLGSENLQTIAYAFGLDKRVPLEIDTTKNQFPPIDGKSDL
AETSIGQGKMLVTPLTMALVASAVANDGVIMKPYLMKYVADPISGAVIEKSTPSQYLNPISKKVADAIKQLMIGAVNDKE
GTGKAAQIPGITVAGKTGTAENPHGDPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRAYLTK

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=457, Percent_Identity=28.0087527352298, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786272, Length=431, Percent_Identity=27.8422273781903, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 51987; Mature: 51855

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLNRNIKILFWFFSVLFFGLIAYLTYFQIYERDKLITSSYSVYNRRLIEQEKKILRGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ILDRNGIVLAKSVQVDGLQKREYLDGPAFAHVIGYSRRIYQQGNTGIEKAYDRELLGMVG
CCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
NDPMILLRKLIFGKGQMGNNVYLTIDKTLQDIAYKDMEGKKGAVVALNPKTGEILAMVST
CCHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEC
PSYDPNTLGENWEEIMTSSEHVVLNRATQGLYPPGSVFKIVTTAAVLTYNPELYDKTFYC
CCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEECCHHHCCEEEE
KGYIIVDGNRINNFGGIAHGIEDFKQAFYRSCNSFFIQAGLDLGSENLQTIAYAFGLDKR
EEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCC
VPLEIDTTKNQFPPIDGKSDLAETSIGQGKMLVTPLTMALVASAVANDGVIMKPYLMKYV
CCEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCEEECHHHHHHH
ADPISGAVIEKSTPSQYLNPISKKVADAIKQLMIGAVNDKEGTGKAAQIPGITVAGKTGT
HCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEECCCCC
AENPHGDPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRAYLTK
CCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLNRNIKILFWFFSVLFFGLIAYLTYFQIYERDKLITSSYSVYNRRLIEQEKKILRGS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
ILDRNGIVLAKSVQVDGLQKREYLDGPAFAHVIGYSRRIYQQGNTGIEKAYDRELLGMVG
CCCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
NDPMILLRKLIFGKGQMGNNVYLTIDKTLQDIAYKDMEGKKGAVVALNPKTGEILAMVST
CCHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEEC
PSYDPNTLGENWEEIMTSSEHVVLNRATQGLYPPGSVFKIVTTAAVLTYNPELYDKTFYC
CCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEECCHHHCCEEEE
KGYIIVDGNRINNFGGIAHGIEDFKQAFYRSCNSFFIQAGLDLGSENLQTIAYAFGLDKR
EEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCCCC
VPLEIDTTKNQFPPIDGKSDLAETSIGQGKMLVTPLTMALVASAVANDGVIMKPYLMKYV
CCEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCEEECHHHHHHH
ADPISGAVIEKSTPSQYLNPISKKVADAIKQLMIGAVNDKEGTGKAAQIPGITVAGKTGT
HCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCEEEECCCCC
AENPHGDPHAWFVGFAPAENPQIVVSVIVENGGEGGKVAAPIARDIIRAYLTK
CCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA