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The map label for this gene is ndoA [H]

Identifier: 167039618

GI number: 167039618

Start: 986760

End: 987110

Strand: Direct

Name: ndoA [H]

Synonym: Teth514_0966

Alternate gene names: 167039618

Gene position: 986760-987110 (Clockwise)

Preceding gene: 167039617

Following gene: 167039619

Centisome position: 40.16

GC content: 34.47

Gene sequence:

>351_bases
ATGGTGATAAAGAGGGGAGACATTTTTTATGCCGATTTAAGCCCTGTAATAGGCTCTGAACAGGGCGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATTGGTAATAAATATAGTCCAACAGTAATAGTAGCGGCAATTACATCTCAGATTAACAAAG
CCAAATTGCCCACTCATGTTGAAATAAATGGGGCAGAATATGGACTTAACAAAGATTCTGTAGTATTATTGGAGCAAATA
AGGACTATTGACAAAAAACGTTTAAGAGAAAAAATTGGTCATTTTGACCAGGAAATGATGGAGAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGGTTGATTGATTTTTAA

Upstream 100 bases:

>100_bases
AGATGGCAGCAATTAACAGTGAACTTGCGGAAATGGGCCTAACCGCAGAAAACGAATGTTTTACAGGATATGAAATGAAA
TTGAAAAAGTGTGATTAACT

Downstream 100 bases:

>100_bases
AAGGTTAACTAATTATAAGGCAGCGCTTAGCGCTGTTTTTTTGTACGGCGAAAAAAGTTTTATGATATAATTATAATTAA
AGTCTTTTATAGTTTTTCCT

Product: transcriptional modulator of MazE/toxin, MazF

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Sequences:

>Translated_116_residues
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF
>Mature_116_residues
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 12933; Mature: 12933

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHV
CEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHCCCCEEE
EINGAEYGLNKDSVVLLEQIRTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEECC
>Mature Secondary Structure
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHV
CEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHCCCCEEE
EINGAEYGLNKDSVVLLEQIRTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]