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The map label for this gene is fhs [H]

Identifier: 167039449

GI number: 167039449

Start: 829018

End: 830685

Strand: Direct

Name: fhs [H]

Synonym: Teth514_0795

Alternate gene names: 167039449

Gene position: 829018-830685 (Clockwise)

Preceding gene: 167039448

Following gene: 167039450

Centisome position: 33.74

GC content: 38.91

Gene sequence:

>1668_bases
ATGAAATCTGATATTGAAATAGCTCAAGAAGCGAAAATGCTACATATAAGGGAGGTTGCAAAAAAGTTAGACATTGAGGA
AGACTACCTAGAATACTACGGCAAGTATAAAGCAAAAATTTCTCCTGCGTTATCGGAGAAAATAAAGGACAGAAAAGATG
GTAAGCTTATTCTTGTCACAGCGATAACTCCCACCCCTGCAGGCGAGGGTAAGACTACACTTACTGTAGGATTAGGACAG
GCTCTTGCTAAAATAGGTAAAAAAGCCATGATAGCTTTAAGAGAGCCCTCATTAGGACCTTGTATGGGAATAAAAGGTGG
AGCGGCTGGGGGAGGATATTCTCAAGTTGTACCTATGGAGGACATAAATTTGCACTTTACAGGAGATTTACATGCGATTA
CTGCTGCTCATAATTTATTGGCTGCTATGATTGACAATCACATCCATCATGGAAATGAACTTAATATTGACATAAGGGCT
ATTACATGGAAAAGAGCTATGGACATGAATGATAGGGCTTTAAGAGAAATAATAGTAGGGCTTGGAGGAAAAGCAAATGG
CTTTCCGCGGCAAGACGGATTTATAATAACAGTTGCCTCAGAAGTAATGGCGATTTTATGTCTAGCTCAAGACTTGATGG
ATCTGAAAAGAAGAATTGGTGATATAATAGTGGCTTATGATAAAGATGGCAATCCTGTAACTGCAAGAGATTTAAAAGCC
GATGGAGCTATGACAGTCTTATTAAAAGATGCTATAAAGCCTAATTTAGTGCAGACGATTGAAAACGTTCCAGCATTTGT
TCATGGAGGGCCTTTTGCAAATATTGCTCATGGATGTAATAGCTTAATTGCCACTAAATATGGTTTGAAATTGGCAGATT
ATCTTGTAACAGAGGCAGGCTTTGGTGCTGATTTAGGGGCTGAAAAATTCTTTGACATAAAGTCAAGGTTTGGAGGACTA
ACACCCAATGCAGCCGTCATAGTAGCGACTGTAAGAGCTTTAAAGATGCATGGAGGAGTTAAGAAGGAAGACTTACAAAA
AGAAGATGTGGAAGCAGTAAGAAGAGGAATAGAAAATCTTGAAAAGCAAGTTGAAAATGTGAGGAAATTTGGGGTACCAG
TGGTTGTAGCTCTCAACAGGTTTGTTTTTGATACTGAAAGGGAAATTGAAGAGGTAAGAAAGGCCTGCGAAGAAATGGGA
GTAGATATGGCAGTAGCGGAAGTTTGGGAAAAAGGAGGAGAAGGCGGAATAGAGTTAGCTGAAAAAGTTGTGAAAGCTTG
TGAGACACCTTCCAACTTCCACGTTTTGTATGATGAAACACTTCCAATTAAAGATAAATTGCACATAATTGCAACAGAAA
TATATGGAGCTGATGGAGTAGAATATACTGCTTCTGCTCTTAAAGATATAGCAAACCTTGAAAGACTAGGCTTTGACAAG
ATGCCAATAGTTGTGGCAAAAACTCAATATTCTCTTTCTGATGACCCTAAACTTTTAGGCCGTCCAAGAGGATTTAAGAT
AACAGTAAGAGAATTGAGAGTTTCAATGGGTGCAGGATTTGTTGTGGTTTTCACAGGAGATATAATGACAATGCCAGGCC
TTCCAAAGCATCCTGCAGCAGAAAACATAGACATTGATGAAAATGGAAGAATAACAGGACTGTTTTGA

Upstream 100 bases:

>100_bases
TACAATGGTGATATTAAAATTTTTAGTAAAAAAGGCAAAGGTACACTTGTAAAAATAATTTTAGGTGAGAGATAAAAATA
AAAGCTGGAGGGGAAAATTT

Downstream 100 bases:

>100_bases
GGGAGTGTAGATGAAAGTAGATGAAAAAAGAAATATTAGATATACAAAATTTGTCACAGGCGAAAAAGGAAATTAGCCAA
ATAAAAGCTGAAGAAATTTC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKSDIEIAQEAKMLHIREVAKKLDIEEDYLEYYGKYKAKISPALSEKIKDRKDGKLILVTAITPTPAGEGKTTLTVGLGQ
ALAKIGKKAMIALREPSLGPCMGIKGGAAGGGYSQVVPMEDINLHFTGDLHAITAAHNLLAAMIDNHIHHGNELNIDIRA
ITWKRAMDMNDRALREIIVGLGGKANGFPRQDGFIITVASEVMAILCLAQDLMDLKRRIGDIIVAYDKDGNPVTARDLKA
DGAMTVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDIKSRFGGL
TPNAAVIVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNRFVFDTEREIEEVRKACEEMG
VDMAVAEVWEKGGEGGIELAEKVVKACETPSNFHVLYDETLPIKDKLHIIATEIYGADGVEYTASALKDIANLERLGFDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRVSMGAGFVVVFTGDIMTMPGLPKHPAAENIDIDENGRITGLF

Sequences:

>Translated_555_residues
MKSDIEIAQEAKMLHIREVAKKLDIEEDYLEYYGKYKAKISPALSEKIKDRKDGKLILVTAITPTPAGEGKTTLTVGLGQ
ALAKIGKKAMIALREPSLGPCMGIKGGAAGGGYSQVVPMEDINLHFTGDLHAITAAHNLLAAMIDNHIHHGNELNIDIRA
ITWKRAMDMNDRALREIIVGLGGKANGFPRQDGFIITVASEVMAILCLAQDLMDLKRRIGDIIVAYDKDGNPVTARDLKA
DGAMTVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDIKSRFGGL
TPNAAVIVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNRFVFDTEREIEEVRKACEEMG
VDMAVAEVWEKGGEGGIELAEKVVKACETPSNFHVLYDETLPIKDKLHIIATEIYGADGVEYTASALKDIANLERLGFDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRVSMGAGFVVVFTGDIMTMPGLPKHPAAENIDIDENGRITGLF
>Mature_555_residues
MKSDIEIAQEAKMLHIREVAKKLDIEEDYLEYYGKYKAKISPALSEKIKDRKDGKLILVTAITPTPAGEGKTTLTVGLGQ
ALAKIGKKAMIALREPSLGPCMGIKGGAAGGGYSQVVPMEDINLHFTGDLHAITAAHNLLAAMIDNHIHHGNELNIDIRA
ITWKRAMDMNDRALREIIVGLGGKANGFPRQDGFIITVASEVMAILCLAQDLMDLKRRIGDIIVAYDKDGNPVTARDLKA
DGAMTVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAGFGADLGAEKFFDIKSRFGGL
TPNAAVIVATVRALKMHGGVKKEDLQKEDVEAVRRGIENLEKQVENVRKFGVPVVVALNRFVFDTEREIEEVRKACEEMG
VDMAVAEVWEKGGEGGIELAEKVVKACETPSNFHVLYDETLPIKDKLHIIATEIYGADGVEYTASALKDIANLERLGFDK
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRVSMGAGFVVVFTGDIMTMPGLPKHPAAENIDIDENGRITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=45.3957996768982, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=46.2035541195477, Blast_Score=480, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=46.0674157303371, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=46.0674157303371, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=44.2857142857143, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=45.12, Blast_Score=482, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=45.3074433656958, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=45.3074433656958, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=45.3074433656958, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=45.3074433656958, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60379; Mature: 60379

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQEAKMLHIREVAKKLDIEEDYLEYYGKYKAKISPALSEKIKDRKDGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEEECHHHHHHHHCCCCCCEEEEE
AITPTPAGEGKTTLTVGLGQALAKIGKKAMIALREPSLGPCMGIKGGAAGGGYSQVVPME
EECCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDLHAITAAHNLLAAMIDNHIHHGNELNIDIRAITWKRAMDMNDRALREIIVG
CCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHCCCCHHHHHHHHHH
LGGKANGFPRQDGFIITVASEVMAILCLAQDLMDLKRRIGDIIVAYDKDGNPVTARDLKA
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEHHHCCC
DGAMTVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAG
CCCEEEEEHHHCCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
FGADLGAEKFFDIKSRFGGLTPNAAVIVATVRALKMHGGVKKEDLQKEDVEAVRRGIENL
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHH
EKQVENVRKFGVPVVVALNRFVFDTEREIEEVRKACEEMGVDMAVAEVWEKGGEGGIELA
HHHHHHHHHHCCHHEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
EKVVKACETPSNFHVLYDETLPIKDKLHIIATEIYGADGVEYTASALKDIANLERLGFDK
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRVSMGAGFVVVFTGDIMTMPGLPKHPAA
CCEEEEEEECCCCCCHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCEEECCCCCCCCCC
ENIDIDENGRITGLF
CCCCCCCCCCEEECC
>Mature Secondary Structure
MKSDIEIAQEAKMLHIREVAKKLDIEEDYLEYYGKYKAKISPALSEKIKDRKDGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHEEECHHHHHHHHCCCCCCEEEEE
AITPTPAGEGKTTLTVGLGQALAKIGKKAMIALREPSLGPCMGIKGGAAGGGYSQVVPME
EECCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDLHAITAAHNLLAAMIDNHIHHGNELNIDIRAITWKRAMDMNDRALREIIVG
CCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHHHCCCCHHHHHHHHHH
LGGKANGFPRQDGFIITVASEVMAILCLAQDLMDLKRRIGDIIVAYDKDGNPVTARDLKA
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEHHHCCC
DGAMTVLLKDAIKPNLVQTIENVPAFVHGGPFANIAHGCNSLIATKYGLKLADYLVTEAG
CCCEEEEEHHHCCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
FGADLGAEKFFDIKSRFGGLTPNAAVIVATVRALKMHGGVKKEDLQKEDVEAVRRGIENL
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHH
EKQVENVRKFGVPVVVALNRFVFDTEREIEEVRKACEEMGVDMAVAEVWEKGGEGGIELA
HHHHHHHHHHCCHHEEEHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHH
EKVVKACETPSNFHVLYDETLPIKDKLHIIATEIYGADGVEYTASALKDIANLERLGFDK
HHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
MPIVVAKTQYSLSDDPKLLGRPRGFKITVRELRVSMGAGFVVVFTGDIMTMPGLPKHPAA
CCEEEEEEECCCCCCHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCEEECCCCCCCCCC
ENIDIDENGRITGLF
CCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA