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The map label for this gene is argH

Identifier: 167039323

GI number: 167039323

Start: 696280

End: 697605

Strand: Direct

Name: argH

Synonym: Teth514_0664

Alternate gene names: 167039323

Gene position: 696280-697605 (Clockwise)

Preceding gene: 167039322

Following gene: 167039324

Centisome position: 28.34

GC content: 36.35

Gene sequence:

>1326_bases
ATGAAGCTGTGGGGAGGTAGGTTTAAAAGCGAGACGGACAAACTAATGGAGGAGTTTAATTCCTCCATTTCTTTTGATAT
TAGGCTTTTAAAGCATGACATATTAGGCTCAATTGCCCATGCAAAAGGACTTTATAAAGCTGGAGTGCTGACAGAAGATG
AACTCAATTTAATAGAAAAAGGGTTAAAGGAAATTCTTGATGAAACCAATGTTGGAGAGATACCAAATGATGAAGATGTT
CATTCTTATGTTGAAAGGCTTTTAACTGAGAAAATAGGCGATGTAGGGCGCAAACTTCACACAGGAAGAAGTCGAAACGA
CCAAGTTGCGACAGATGAAAGGCTTTATTTAAGAGATGAGATAGACAAAATAAAAGAGGATTTAATAAAACTTATAGATA
CCTTAAAAGAAATGGCTGAAACTTATAAAAAGGCGATTATGCCGGGATATACGCATCTGCAAAGGGCTCAGCCTGTGACT
TTTGGACATCATCTTCTTGCCTATGTTGAAATGTTTAAAAGAGATTTATCAAGGCTTGAGGATATGTACAAGAGGGTCAA
TGTAATGCCTTTAGGTTCAGGTGCTCTTGCAGGTACTACATTTGATATTGATAGAAAATATGTAGCCTCCCTTTTAGGGT
TCGATGATATAACTTTAAATAGTATGGACGGTGTAAGCGATAGAGACTTTGTAATAGAATTTTTAAGCTTTGCCTCTATA
ACAATGATGCATTTAAGTAGGTTTTGTGAAGAATTAATTTTGTGGTCCACCAAAGAATTTGATTTTATTGAAATGGACGA
TAGATTCTCAACAGGAAGCAGCATGATGCCACAAAAGAAAAACCCCGATGCAGCAGAATTAATAAGGGGTAAAACCGGCA
GGGTTTACGGCGATTTGATTACAATACTTACTGTGATGAAAGGACTCTCTCTTGCATATAACAAAGACATGCAGGAGGAT
AAAGAGGCTTTGTTTGATGGAATAGACACTTTAAAAATGTCTTTGAAAGTATTTACTGAGATGATAAAGACGATTAAAGT
AAAGACTGACAACATGGAAAAAGCCGCAAAATATGGTTATATGAATGCCACAGATTTTGCGGACTATCTCGTGTCAAAGG
GTATCCCTTTCAGAACTGCCCATGAAATTGCAGGCAAAGTCGTTTTATACGCAATAGAGAGAAACTTAGCTATTGAAGAT
TTGCCACTTAATGAACTTAAAAAATTCAGCGATGTGATAGATGAAGATGTATATGAGGCAATAGACCTTAAAAACACATT
AAAAAAGAAAAAGACAATAGGTGCGCCAACGTCAATCCAATCTTGA

Upstream 100 bases:

>100_bases
GACGAAGTCTACAACCAAAAAGACGCAGAAGGATTTATAAACCTCTTTGGGCTTTCTTTAAAAATTAAGGCGTTGATGGA
AATGGAGAGGAAGGATATGG

Downstream 100 bases:

>100_bases
TTTTACGAATAGATCCATTTTTACAAAAAGTATTTTTTATTATATAATAAGTATTGAAAATAAAAAACTAGATTATTCTT
TACGTTAAAGGGGAGTAGCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKLWGGRFKSETDKLMEEFNSSISFDIRLLKHDILGSIAHAKGLYKAGVLTEDELNLIEKGLKEILDETNVGEIPNDEDV
HSYVERLLTEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKKAIMPGYTHLQRAQPVT
FGHHLLAYVEMFKRDLSRLEDMYKRVNVMPLGSGALAGTTFDIDRKYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLSLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVSKGIPFRTAHEIAGKVVLYAIERNLAIED
LPLNELKKFSDVIDEDVYEAIDLKNTLKKKKTIGAPTSIQS

Sequences:

>Translated_441_residues
MKLWGGRFKSETDKLMEEFNSSISFDIRLLKHDILGSIAHAKGLYKAGVLTEDELNLIEKGLKEILDETNVGEIPNDEDV
HSYVERLLTEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKKAIMPGYTHLQRAQPVT
FGHHLLAYVEMFKRDLSRLEDMYKRVNVMPLGSGALAGTTFDIDRKYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLSLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVSKGIPFRTAHEIAGKVVLYAIERNLAIED
LPLNELKKFSDVIDEDVYEAIDLKNTLKKKKTIGAPTSIQS
>Mature_441_residues
MKLWGGRFKSETDKLMEEFNSSISFDIRLLKHDILGSIAHAKGLYKAGVLTEDELNLIEKGLKEILDETNVGEIPNDEDV
HSYVERLLTEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKKAIMPGYTHLQRAQPVT
FGHHLLAYVEMFKRDLSRLEDMYKRVNVMPLGSGALAGTTFDIDRKYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLSLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVSKGIPFRTAHEIAGKVVLYAIERNLAIED
LPLNELKKFSDVIDEDVYEAIDLKNTLKKKKTIGAPTSIQS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=437, Percent_Identity=47.8260869565217, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI68303542, Length=437, Percent_Identity=47.8260869565217, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI68303547, Length=437, Percent_Identity=45.766590389016, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=437, Percent_Identity=45.3089244851259, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI1790398, Length=444, Percent_Identity=52.2522522522522, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6321806, Length=440, Percent_Identity=45.9090909090909, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221473854, Length=441, Percent_Identity=46.2585034013605, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI78706858, Length=441, Percent_Identity=46.2585034013605, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_THEP3 (B0KBW6)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001664238.1
- ProteinModelPortal:   B0KBW6
- SMR:   B0KBW6
- GeneID:   5874222
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_0230
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   TPSE340099:TETH39_0230-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50191; Mature: 50191

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKSETDKLMEEFNSSISFDIRLLKHDILGSIAHAKGLYKAGVLTEDELNLIEK
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GLKEILDETNVGEIPNDEDVHSYVERLLTEKIGDVGRKLHTGRSRNDQVATDERLYLRDE
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IDKIKEDLIKLIDTLKEMAETYKKAIMPGYTHLQRAQPVTFGHHLLAYVEMFKRDLSRLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DMYKRVNVMPLGSGALAGTTFDIDRKYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
HHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHH
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLI
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHH
TILTVMKGLSLAYNKDMQEDKEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
MNATDFADYLVSKGIPFRTAHEIAGKVVLYAIERNLAIEDLPLNELKKFSDVIDEDVYEA
CCHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
IDLKNTLKKKKTIGAPTSIQS
HHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKLWGGRFKSETDKLMEEFNSSISFDIRLLKHDILGSIAHAKGLYKAGVLTEDELNLIEK
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GLKEILDETNVGEIPNDEDVHSYVERLLTEKIGDVGRKLHTGRSRNDQVATDERLYLRDE
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IDKIKEDLIKLIDTLKEMAETYKKAIMPGYTHLQRAQPVTFGHHLLAYVEMFKRDLSRLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DMYKRVNVMPLGSGALAGTTFDIDRKYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
HHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHH
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLI
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHH
TILTVMKGLSLAYNKDMQEDKEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
MNATDFADYLVSKGIPFRTAHEIAGKVVLYAIERNLAIEDLPLNELKKFSDVIDEDVYEA
CCHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
IDLKNTLKKKKTIGAPTSIQS
HHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA