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The map label for this gene is thiD [H]

Identifier: 167039224

GI number: 167039224

Start: 589853

End: 590647

Strand: Direct

Name: thiD [H]

Synonym: Teth514_0565

Alternate gene names: 167039224

Gene position: 589853-590647 (Clockwise)

Preceding gene: 167039223

Following gene: 167039225

Centisome position: 24.0

GC content: 37.48

Gene sequence:

>795_bases
ATGAAATTAGCCCTTACTATTGCCGGTTCTGATTCTGGGGGAGGAGCAGGTATACAGGCAGATTTAAAGACTTTTTCAGC
CCATGGAGTATACGGCATGAGTGTCATTACTTCAATAACAGCGCAAAATACCATGGGGGTTTTGGGAATTGAGGATATAA
GCCCCGATATGGTGTATTTGCAGATGAAGGCAATTTTTGAGGATTTATATCCAGATGCAGTGAAGATAGGTATGGTATCT
AATGAAAGCATAATTAAAATGATTGCAAAAGGGTTAAAAGATTACAATGTAAAAAATGTTGTGCTGGACCCTGTCATGAT
TTCAAAGAGTGGAAGCTATTTATTAAAGCCGGAAGCAGTGGAGGCTTTGAAAAAGGAATTGATTCCTTTAAGCCTTGTAG
TTACTCCAAATCTTATGGAAGCGGGAGAATTAATTGGAAAAGAAATTAAAAATGTATCGGATATGAAGGAAGCGGCTAAA
AAAATTTTAGATTATGGAGCAAAGACAGTAATTGTAAAAGGTGGACATCTTACAGGAGATGCTTTAGATGTATTTTACGA
TGGAAAAGAGTTTTATGAAATTACATCAGAGAGGATTGATACTAAAAACACGCATGGTACAGGCTGCACATTTTCCTCAG
CTATAGCTGCCAATATTGCTTTAGGCCATGATTTAGTTGAGTCGATAAAAAGAGCGAAAGCATACATTACAGGGGCTATA
AAACATTCGTTGGCCATAGGGCATGGAGTAGGTCCTACTAACCATTTTTGGAATATAGAAATAAGGAAGGTGTGA

Upstream 100 bases:

>100_bases
CTGTCAGGGTAATGCCTGCGTAGGGAAGCATGCTTTTTAAAACATTTGTAAAAATGCTCACCTCACAGGTGGGCTTATTT
TATTATTTGGAGGTGTTTTT

Downstream 100 bases:

>100_bases
GATATGGACTTAACCCTTTATGCTATAACGGATAGGTCTTACATAAAGAATATGGATATTGCTGAAGCAGTAGAACTAGC
GATAAAAGGCGGTGCAACAG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMKAIFEDLYPDAVKIGMVS
NESIIKMIAKGLKDYNVKNVVLDPVMISKSGSYLLKPEAVEALKKELIPLSLVVTPNLMEAGELIGKEIKNVSDMKEAAK
KILDYGAKTVIVKGGHLTGDALDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAI
KHSLAIGHGVGPTNHFWNIEIRKV

Sequences:

>Translated_264_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMKAIFEDLYPDAVKIGMVS
NESIIKMIAKGLKDYNVKNVVLDPVMISKSGSYLLKPEAVEALKKELIPLSLVVTPNLMEAGELIGKEIKNVSDMKEAAK
KILDYGAKTVIVKGGHLTGDALDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAI
KHSLAIGHGVGPTNHFWNIEIRKV
>Mature_264_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYLQMKAIFEDLYPDAVKIGMVS
NESIIKMIAKGLKDYNVKNVVLDPVMISKSGSYLLKPEAVEALKKELIPLSLVVTPNLMEAGELIGKEIKNVSDMKEAAK
KILDYGAKTVIVKGGHLTGDALDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAI
KHSLAIGHGVGPTNHFWNIEIRKV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=44.3579766536965, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17507757, Length=287, Percent_Identity=27.5261324041812, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507759, Length=277, Percent_Identity=26.3537906137184, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=34.4202898550725, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=34.6570397111913, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324517, Length=277, Percent_Identity=33.2129963898917, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28273; Mature: 28273

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYL
CEEEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEH
QMKAIFEDLYPDAVKIGMVSNESIIKMIAKGLKDYNVKNVVLDPVMISKSGSYLLKPEAV
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEECCCCEEECHHHH
EALKKELIPLSLVVTPNLMEAGELIGKEIKNVSDMKEAAKKILDYGAKTVIVKGGHLTGD
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
ALDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHSLAIGHGVGPTNHFWNIEIRKV
HHHHHHCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MKLALTIAGSDSGGGAGIQADLKTFSAHGVYGMSVITSITAQNTMGVLGIEDISPDMVYL
CEEEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEH
QMKAIFEDLYPDAVKIGMVSNESIIKMIAKGLKDYNVKNVVLDPVMISKSGSYLLKPEAV
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEECCCCEEECHHHH
EALKKELIPLSLVVTPNLMEAGELIGKEIKNVSDMKEAAKKILDYGAKTVIVKGGHLTGD
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
ALDVFYDGKEFYEITSERIDTKNTHGTGCTFSSAIAANIALGHDLVESIKRAKAYITGAI
EEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHSLAIGHGVGPTNHFWNIEIRKV
HHHHHHCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]