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The map label for this gene is purM [H]

Identifier: 167039182

GI number: 167039182

Start: 539074

End: 540084

Strand: Direct

Name: purM [H]

Synonym: Teth514_0523

Alternate gene names: 167039182

Gene position: 539074-540084 (Clockwise)

Preceding gene: 167039181

Following gene: 167039183

Centisome position: 21.94

GC content: 35.11

Gene sequence:

>1011_bases
ATGAATTATAAAGATGCTGGGGTAAATATAGATGAAGGCAATAAACTGGTGAAAATGATAAAACCTATTGCAAAAACGAC
TTTGACAGCCAATGTTTTAGAAGGCATTGGGGGATTTGCGGGGCTTTTCGAGATAAAAAATTATAAAAATCCTGTGCTTA
TATCCAGCACTGATGGAGTTGGGACAAAACTTAAAATAGCCTTTATGATGGACAAACACGATACTGTAGGGATAGACCTT
GTAGCTATGTGTGTAAATGACGTTATTGTAACTGGGGCTAAGCCTTTGTTTTTTCTTGACTATTTTGCTACAGGAAAGTT
AAAAAGTGAGACTGCAGTAGAAGTAATCAAAGGAATAGCAGAGGGTTGTAAAATAGCCGGGTGTGCTTTGATAGGAGGAG
AAACAGCAGAACTTCCAGGTTTTTATAAAGAAGGAGAGTATGATTTAGCAGGCTTTTGTGTAGGAATTGTAGAAAAAGAA
GAGCTGATTGATACAAAATCAATAAAAAAAGGAGATGCCATAATTGGGCTTGCCTCTTCTGGAATTCACAGCAATGGCTA
TTCTTTAGTGAGGAAAGTCTTTTTTGAGAAAAACAATTTTTCAGTAAAAGACTTTATACCAGAGCTTGGCATGAATTTAG
GAGATGCACTCCTTACCCCTACAAAAATATATGTCAAGTCAATAGAGGCTTTAAAAGAGTTAAAAATTAAAGGAATGGCT
CATATTACCGGAGGAGGTTTTATTGACAATATTCCAAGAATACTAAGAAAAAGTATAGCTGCAAAAATAAATAAAGGAAG
TTGGAAAATTCCAACCATTTTTAACTTGATTCAAAGATTGGGAGATATTGAAGAAAGAGAAATGTATCGCACTTTTAATA
TGGGGATTGGCATGGTAGTTATAGTAGACCCTTCTGATGTAGATAAGGCTTTAGAAAAATTAAATGGCATAGGTGAAAAA
GCTTATGTAATAGGGGAGATAGTAGAAAGCGAAGGCGGTGTAATTTTATGA

Upstream 100 bases:

>100_bases
CTATTTGCACAGGTTGCTTTGATGACGACTATCCTATGTATGTTCCAAAAGAAGGGAGTAAGTATCTTTTTGAGAAAAAA
TAAAAAGTAGGTGTATAATT

Downstream 100 bases:

>100_bases
ACCTTGTGGTGATGGCATCAGGTAACGGGACTGATTTGCAGTCAATAATTGATGCCATTGAAGAAGGATATATAAATGCC
AGGATAATTGCCGTCATTAG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIAEGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
ELIDTKSIKKGDAIIGLASSGIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMA
HITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVVIVDPSDVDKALEKLNGIGEK
AYVIGEIVESEGGVIL

Sequences:

>Translated_336_residues
MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIAEGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
ELIDTKSIKKGDAIIGLASSGIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMA
HITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVVIVDPSDVDKALEKLNGIGEK
AYVIGEIVESEGGVIL
>Mature_336_residues
MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGVGTKLKIAFMMDKHDTVGIDL
VAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIAEGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKE
ELIDTKSIKKGDAIIGLASSGIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMA
HITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVVIVDPSDVDKALEKLNGIGEK
AYVIGEIVESEGGVIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=48.377581120944, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=48.377581120944, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=48.377581120944, Blast_Score=321, Evalue=7e-88,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=53.1157270029674, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=43.2748538011696, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=42.4778761061947, Blast_Score=285, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=44.0559440559441, Blast_Score=244, Evalue=8e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36324; Mature: 36324

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCC
GTKLKIAFMMDKHDTVGIDLVAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIA
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCCHHHHHHHHHHHH
EGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKEELIDTKSIKKGDAIIGLASS
HCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHHHHHCCCCCCEEEEEECC
GIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCEE
HITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVV
EECCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHHCCCCCEEE
IVDPSDVDKALEKLNGIGEKAYVIGEIVESEGGVIL
EECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEC
>Mature Secondary Structure
MNYKDAGVNIDEGNKLVKMIKPIAKTTLTANVLEGIGGFAGLFEIKNYKNPVLISSTDGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCC
GTKLKIAFMMDKHDTVGIDLVAMCVNDVIVTGAKPLFFLDYFATGKLKSETAVEVIKGIA
CCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHEEEEHHHCCCCCHHHHHHHHHHHH
EGCKIAGCALIGGETAELPGFYKEGEYDLAGFCVGIVEKEELIDTKSIKKGDAIIGLASS
HCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHEEEHHHHHHHHHHHCCCCCCEEEEEECC
GIHSNGYSLVRKVFFEKNNFSVKDFIPELGMNLGDALLTPTKIYVKSIEALKELKIKGMA
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCEE
HITGGGFIDNIPRILRKSIAAKINKGSWKIPTIFNLIQRLGDIEEREMYRTFNMGIGMVV
EECCCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHHCCCCCEEE
IVDPSDVDKALEKLNGIGEKAYVIGEIVESEGGVIL
EECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA