Click here to switch to the map view.

The map label for this gene is gcvPA [H]

Identifier: 167038899

GI number: 167038899

Start: 241677

End: 243020

Strand: Reverse

Name: gcvPA [H]

Synonym: Teth514_0230

Alternate gene names: 167038899

Gene position: 243020-241677 (Counterclockwise)

Preceding gene: 167038900

Following gene: 167038898

Centisome position: 9.89

GC content: 37.5

Gene sequence:

>1344_bases
ATGTTTCCTTACCTTCCTGCCTCCTCCAATGACGAAAAAGAAATGCTTAAAACAATAGGAAAAAATTCTATAGAAGAGCT
ATTTGAAAACATACCTCAAGAAGTTCGCTTAAAAAGGCCTTTAAATCTTGGAAATCCAATGTCAGAAGTAGAACTTACAG
CTCACATAAAGAAATGCGCCAAAGAAAATAAAAGCCTTGAAGAGCTGACAAGTTTTTTAGGCGCTGGAGTATATGACCAT
TACATTCCTTCTGTGGTAAAGCACATAATATCTCGTTCTGAATTCTACACGGCCTACACTCCTTACCAGCCAGAAATAAG
CCAAGGAACACTACAAGCTATCTTTGAGTACCAGACAATGATTACAAAACTTACAGGAATGGAAGTCACAAACGCTTCAA
TGTACGACGGAGCAACAGCCTGCGCAGAAGCTGCAATTATGGCTTGTGAAAACACCAAAAGGAAGTCTATAATAGTTTCA
AAAACTGTAAATCCAGAAACGCGAAAAGTTTTAAAGACTTATATGCATTTTAGAGATATCCAAGTAATTGAAATAGACGA
TAATGAAGGAGTAACAGATTTAGAAAAATTAAAAGCGGAAATTGGGACTAACACTGCGGCAGTAATTGTACAGTATCCTA
ATTTCATGGGAATCATCGAAGACCTGCAAGAAATTGAGAAAATAACCCATGAAAATAAAGCAATGTTGATAACTTACGTA
CATCCAATACCTCTCGGCATACTTAAATCGCCAGGAGAAATTGGCGCAGATATAGCTGTAGGAGACGGTCAGTCTCTTGG
CAATGGGTTAAATTTTGGTGGCCCTTATCTTGGTTTTTTAGCTACAACACAAAAGCTTGTGCGGAAAATGCCAGGAAGAA
TAGTAGGCCAGACAAAAGACGTAGATGGTAGACGTGCTTTTGTGCTTACTTTGCAAGCAAGAGAGCAACACATAAGAAGG
GAAAAAGCCACTTCGAATATATGCTCAAACCACTCATTAAATGCCTTAACAGCTGCAGTGTATCTAGCAACTATGGGCAA
AAAAGGTATAAAAGAAGTGGCTTATCAGTGCACTCAAAAGGCTCATTACGCTTTTTCAATGCTTACCGCATCAGGAAAAT
ATAAACCTGCTTTTAACAAGCCCTTCTTTATGGAATTTGCATTAAAGGCTGATGTAGATGTAGACTTAATTAATAAAAAA
CTTTTAGAAAAGGGCATATTAGGCGGATACAACCTCCACAGAGATTACGACAAATACAAAAATACAATGTTACTGGCCTT
TACAGAAAAAAGGACAAAAGAAGAAATTGATGAGTTAAAAGCTCTGTTGGAGGTGATAGAATGA

Upstream 100 bases:

>100_bases
GGCAGTTGGATGGCATTAGTAGAACTCAAAGACAAGTCACAGCTTGATAATTTGATGACAGCCGAAGAATATAAAAAATT
TTTAGATGAGGAGTGAGAGC

Downstream 100 bases:

>100_bases
AAGAGTACAATAAATTGATATTTGAATTGTCAAAGAAAGGAAGAAAAGCCTACACTCTCCCTAAGTTGGATATAGAAGAA
AAACCTTTAGAAGACATACT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFPYLPASSNDEKEMLKTIGKNSIEELFENIPQEVRLKRPLNLGNPMSEVELTAHIKKCAKENKSLEELTSFLGAGVYDH
YIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITKLTGMEVTNASMYDGATACAEAAIMACENTKRKSIIVS
KTVNPETRKVLKTYMHFRDIQVIEIDDNEGVTDLEKLKAEIGTNTAAVIVQYPNFMGIIEDLQEIEKITHENKAMLITYV
HPIPLGILKSPGEIGADIAVGDGQSLGNGLNFGGPYLGFLATTQKLVRKMPGRIVGQTKDVDGRRAFVLTLQAREQHIRR
EKATSNICSNHSLNALTAAVYLATMGKKGIKEVAYQCTQKAHYAFSMLTASGKYKPAFNKPFFMEFALKADVDVDLINKK
LLEKGILGGYNLHRDYDKYKNTMLLAFTEKRTKEEIDELKALLEVIE

Sequences:

>Translated_447_residues
MFPYLPASSNDEKEMLKTIGKNSIEELFENIPQEVRLKRPLNLGNPMSEVELTAHIKKCAKENKSLEELTSFLGAGVYDH
YIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITKLTGMEVTNASMYDGATACAEAAIMACENTKRKSIIVS
KTVNPETRKVLKTYMHFRDIQVIEIDDNEGVTDLEKLKAEIGTNTAAVIVQYPNFMGIIEDLQEIEKITHENKAMLITYV
HPIPLGILKSPGEIGADIAVGDGQSLGNGLNFGGPYLGFLATTQKLVRKMPGRIVGQTKDVDGRRAFVLTLQAREQHIRR
EKATSNICSNHSLNALTAAVYLATMGKKGIKEVAYQCTQKAHYAFSMLTASGKYKPAFNKPFFMEFALKADVDVDLINKK
LLEKGILGGYNLHRDYDKYKNTMLLAFTEKRTKEEIDELKALLEVIE
>Mature_447_residues
MFPYLPASSNDEKEMLKTIGKNSIEELFENIPQEVRLKRPLNLGNPMSEVELTAHIKKCAKENKSLEELTSFLGAGVYDH
YIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMITKLTGMEVTNASMYDGATACAEAAIMACENTKRKSIIVS
KTVNPETRKVLKTYMHFRDIQVIEIDDNEGVTDLEKLKAEIGTNTAAVIVQYPNFMGIIEDLQEIEKITHENKAMLITYV
HPIPLGILKSPGEIGADIAVGDGQSLGNGLNFGGPYLGFLATTQKLVRKMPGRIVGQTKDVDGRRAFVLTLQAREQHIRR
EKATSNICSNHSLNALTAAVYLATMGKKGIKEVAYQCTQKAHYAFSMLTASGKYKPAFNKPFFMEFALKADVDVDLINKK
LLEKGILGGYNLHRDYDKYKNTMLLAFTEKRTKEEIDELKALLEVIE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=415, Percent_Identity=35.1807228915663, Blast_Score=258, Evalue=6e-69,
Organism=Escherichia coli, GI1789269, Length=348, Percent_Identity=35.632183908046, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17535605, Length=369, Percent_Identity=38.2113821138211, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6323843, Length=452, Percent_Identity=32.9646017699115, Blast_Score=243, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24645648, Length=388, Percent_Identity=37.6288659793814, Blast_Score=265, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 50029; Mature: 50029

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPYLPASSNDEKEMLKTIGKNSIEELFENIPQEVRLKRPLNLGNPMSEVELTAHIKKCA
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KENKSLEELTSFLGAGVYDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTM
HHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCHHHHHHHHHHHHH
ITKLTGMEVTNASMYDGATACAEAAIMACENTKRKSIIVSKTVNPETRKVLKTYMHFRDI
HHHHCCCEECCCCHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCE
QVIEIDDNEGVTDLEKLKAEIGTNTAAVIVQYPNFMGIIEDLQEIEKITHENKAMLITYV
EEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEE
HPIPLGILKSPGEIGADIAVGDGQSLGNGLNFGGPYLGFLATTQKLVRKMPGRIVGQTKD
CCCCHHHCCCCCCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCC
VDGRRAFVLTLQAREQHIRREKATSNICSNHSLNALTAAVYLATMGKKGIKEVAYQCTQK
CCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYAFSMLTASGKYKPAFNKPFFMEFALKADVDVDLINKKLLEKGILGGYNLHRDYDKYK
HHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHC
NTMLLAFTEKRTKEEIDELKALLEVIE
CEEEEEEECHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFPYLPASSNDEKEMLKTIGKNSIEELFENIPQEVRLKRPLNLGNPMSEVELTAHIKKCA
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KENKSLEELTSFLGAGVYDHYIPSVVKHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTM
HHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCHHHHHHHHHHHHH
ITKLTGMEVTNASMYDGATACAEAAIMACENTKRKSIIVSKTVNPETRKVLKTYMHFRDI
HHHHCCCEECCCCHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCE
QVIEIDDNEGVTDLEKLKAEIGTNTAAVIVQYPNFMGIIEDLQEIEKITHENKAMLITYV
EEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEE
HPIPLGILKSPGEIGADIAVGDGQSLGNGLNFGGPYLGFLATTQKLVRKMPGRIVGQTKD
CCCCHHHCCCCCCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCC
VDGRRAFVLTLQAREQHIRREKATSNICSNHSLNALTAAVYLATMGKKGIKEVAYQCTQK
CCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYAFSMLTASGKYKPAFNKPFFMEFALKADVDVDLINKKLLEKGILGGYNLHRDYDKYK
HHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHC
NTMLLAFTEKRTKEEIDELKALLEVIE
CEEEEEEECHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]