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The map label for this gene is gcvPB [H]

Identifier: 167038898

GI number: 167038898

Start: 240226

End: 241680

Strand: Reverse

Name: gcvPB [H]

Synonym: Teth514_0229

Alternate gene names: 167038898

Gene position: 241680-240226 (Counterclockwise)

Preceding gene: 167038899

Following gene: 167038889

Centisome position: 9.84

GC content: 38.42

Gene sequence:

>1455_bases
ATGAAAGAGTACAATAAATTGATATTTGAATTGTCAAAGAAAGGAAGAAAAGCCTACACTCTCCCTAAGTTGGATATAGA
AGAAAAACCTTTAGAAGACATACTTCCGCAACAAATGATGAGAAAAGAAGAAATAGAGCTTCCCGAAGTAAGTGAAGTAG
ACATAATAAGACATTACACCCTTTTGTCAAATAAAAACTACGGCGTCGATACGGGTTTTTATCCATTAGGTTCTTGTACT
ATGAAGTACAATCCTAAAATAAATGAAGACATGGCATCCCTTATCGGTTTTACAGCTCTACATCCCTATCAACCAGTAGA
AACTGTGCAAGGCGCTTTGAAACTCATGTATGAATTAGAAAACATGCTCTCTGAAATAACTGGAATGGACAAATTTTCAT
TACAGCCTGCTGCAGGTGCCCACGGAGAATTGACGGGACTCATGATAATTAAGGCCTATCACGAACACAGAAATGACAAA
AAACGTAAAAAAATAATCGTGCCAGACTCTGCTCATGGTACTAACCCCGCCAGTGCAGCAGTTGCAGGTTTTGACGTTAT
TGAAATTAAGTCTAACAAAGAAGGTGCAATAGACCTTGAGGCGTTAAAAGCCGTTTTAAATGAGGAAGTAGCAGGACTTA
TGCTTACAAACCCCAGCACTTTAGGGCTTTTTGAAGAAAATATAGTAGAAATCGCAAGACTAGTACACGAAGCAGGAGGA
CTTTTGTATTACGATGGTGCAAATCTAAATGCTATAATGGGAATCACACGCCCTGGAGACATGGGATTTGACGTTGTACA
TCTAAATCTTCACAAGACCTTCTCTACACCTCATGGCGGTGGTGGCCCGGGTTCTGGACCTGTAGGTGTCAAAAAAGAGC
TTGCCGACTTTTTGCCAGTGCCTGTAATAGAATTTAAAGACGGCATATATAGCTTAAACTATGATAGGCCGCTTTCTATT
GGAAAAGTGAGAAGCTTTTATGGCAACTTCAATGTGCTTATAAAGGCTTATTCCTACATTTTAACTATGGGAGCTGAAGG
ACTTAAGAGAGCCAGCGAAATGGCAGTTTTAAATGCTAATTATCTTAAAGAAAAACTCAAAAATCACTACAAAGTCGCTA
TTGACAAAGTATGCATGCATGAATTTGTTTTAGCTGGTCTTTTAGAAAAAGTCAATGATATCACAACATTAGATGTAGCT
AAAAGACTTATAGATTACGGTTTCCATCCACCCACAATATATTTCCCATTAATTGTTGACAGCGCCATAATGGTAGAGCC
TACTGAAACAGAAAGTAAAGAAACATTAGACGCTTTCATTGAAGCAATGATTAAAATAGCAGAGGAAGCAAAAGAAAATC
CGCAACTTTTAAAAGAAGCTCCACACAACACGCCTGTAAGAAGGGTTGATGAGGTACTGGCTGCAAGAAATCCTGTTTTA
AAGTGGAGCAAATAG

Upstream 100 bases:

>100_bases
GAGATTACGACAAATACAAAAATACAATGTTACTGGCCTTTACAGAAAAAAGGACAAAAGAAGAAATTGATGAGTTAAAA
GCTCTGTTGGAGGTGATAGA

Downstream 100 bases:

>100_bases
AGGGGGACCATTGAAAAAGCGGGGGATAAAAAAGACGGGACATACCCGTCTTTTTTATCTTTCCTTGCTGCGAGTTGCTA
CATCAAATATGACAGCGGCA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKEYNKLIFELSKKGRKAYTLPKLDIEEKPLEDILPQQMMRKEEIELPEVSEVDIIRHYTLLSNKNYGVDTGFYPLGSCT
MKYNPKINEDMASLIGFTALHPYQPVETVQGALKLMYELENMLSEITGMDKFSLQPAAGAHGELTGLMIIKAYHEHRNDK
KRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNEEVAGLMLTNPSTLGLFEENIVEIARLVHEAGG
LLYYDGANLNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPVIEFKDGIYSLNYDRPLSI
GKVRSFYGNFNVLIKAYSYILTMGAEGLKRASEMAVLNANYLKEKLKNHYKVAIDKVCMHEFVLAGLLEKVNDITTLDVA
KRLIDYGFHPPTIYFPLIVDSAIMVEPTETESKETLDAFIEAMIKIAEEAKENPQLLKEAPHNTPVRRVDEVLAARNPVL
KWSK

Sequences:

>Translated_484_residues
MKEYNKLIFELSKKGRKAYTLPKLDIEEKPLEDILPQQMMRKEEIELPEVSEVDIIRHYTLLSNKNYGVDTGFYPLGSCT
MKYNPKINEDMASLIGFTALHPYQPVETVQGALKLMYELENMLSEITGMDKFSLQPAAGAHGELTGLMIIKAYHEHRNDK
KRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNEEVAGLMLTNPSTLGLFEENIVEIARLVHEAGG
LLYYDGANLNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPVIEFKDGIYSLNYDRPLSI
GKVRSFYGNFNVLIKAYSYILTMGAEGLKRASEMAVLNANYLKEKLKNHYKVAIDKVCMHEFVLAGLLEKVNDITTLDVA
KRLIDYGFHPPTIYFPLIVDSAIMVEPTETESKETLDAFIEAMIKIAEEAKENPQLLKEAPHNTPVRRVDEVLAARNPVL
KWSK
>Mature_484_residues
MKEYNKLIFELSKKGRKAYTLPKLDIEEKPLEDILPQQMMRKEEIELPEVSEVDIIRHYTLLSNKNYGVDTGFYPLGSCT
MKYNPKINEDMASLIGFTALHPYQPVETVQGALKLMYELENMLSEITGMDKFSLQPAAGAHGELTGLMIIKAYHEHRNDK
KRKKIIVPDSAHGTNPASAAVAGFDVIEIKSNKEGAIDLEALKAVLNEEVAGLMLTNPSTLGLFEENIVEIARLVHEAGG
LLYYDGANLNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPVPVIEFKDGIYSLNYDRPLSI
GKVRSFYGNFNVLIKAYSYILTMGAEGLKRASEMAVLNANYLKEKLKNHYKVAIDKVCMHEFVLAGLLEKVNDITTLDVA
KRLIDYGFHPPTIYFPLIVDSAIMVEPTETESKETLDAFIEAMIKIAEEAKENPQLLKEAPHNTPVRRVDEVLAARNPVL
KWSK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=45.1162790697674, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1789269, Length=447, Percent_Identity=42.7293064876958, Blast_Score=302, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17535605, Length=427, Percent_Identity=43.3255269320843, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI32564013, Length=381, Percent_Identity=44.6194225721785, Blast_Score=283, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323843, Length=451, Percent_Identity=43.9024390243902, Blast_Score=327, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24645648, Length=439, Percent_Identity=46.2414578587699, Blast_Score=330, Evalue=9e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53832; Mature: 53832

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYNKLIFELSKKGRKAYTLPKLDIEEKPLEDILPQQMMRKEEIELPEVSEVDIIRHYT
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LLSNKNYGVDTGFYPLGSCTMKYNPKINEDMASLIGFTALHPYQPVETVQGALKLMYELE
HCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NMLSEITGMDKFSLQPAAGAHGELTGLMIIKAYHEHRNDKKRKKIIVPDSAHGTNPASAA
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCEEECCCCCCCCCCHHHH
VAGFDVIEIKSNKEGAIDLEALKAVLNEEVAGLMLTNPSTLGLFEENIVEIARLVHEAGG
HCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
PVIEFKDGIYSLNYDRPLSIGKVRSFYGNFNVLIKAYSYILTMGAEGLKRASEMAVLNAN
CCEEECCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
YLKEKLKNHYKVAIDKVCMHEFVLAGLLEKVNDITTLDVAKRLIDYGFHPPTIYFPLIVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEHHHHC
SAIMVEPTETESKETLDAFIEAMIKIAEEAKENPQLLKEAPHNTPVRRVDEVLAARNPVL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCC
KWSK
CCCC
>Mature Secondary Structure
MKEYNKLIFELSKKGRKAYTLPKLDIEEKPLEDILPQQMMRKEEIELPEVSEVDIIRHYT
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LLSNKNYGVDTGFYPLGSCTMKYNPKINEDMASLIGFTALHPYQPVETVQGALKLMYELE
HCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NMLSEITGMDKFSLQPAAGAHGELTGLMIIKAYHEHRNDKKRKKIIVPDSAHGTNPASAA
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCEEECCCCCCCCCCHHHH
VAGFDVIEIKSNKEGAIDLEALKAVLNEEVAGLMLTNPSTLGLFEENIVEIARLVHEAGG
HCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKKELADFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCC
PVIEFKDGIYSLNYDRPLSIGKVRSFYGNFNVLIKAYSYILTMGAEGLKRASEMAVLNAN
CCEEECCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
YLKEKLKNHYKVAIDKVCMHEFVLAGLLEKVNDITTLDVAKRLIDYGFHPPTIYFPLIVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEHHHHC
SAIMVEPTETESKETLDAFIEAMIKIAEEAKENPQLLKEAPHNTPVRRVDEVLAARNPVL
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCC
KWSK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]