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The map label for this gene is yqjI [H]

Identifier: 167038812

GI number: 167038812

Start: 136314

End: 137723

Strand: Direct

Name: yqjI [H]

Synonym: Teth514_0139

Alternate gene names: 167038812

Gene position: 136314-137723 (Clockwise)

Preceding gene: 167038811

Following gene: 167038813

Centisome position: 5.55

GC content: 31.28

Gene sequence:

>1410_bases
ATGATAAAAGCTGACATTGGTTTAATAGGCCTTGGGGTGATGGGACAAAATTTAGCATTGAATATTGCAAGAAATGGATA
TGCTGTCTCTGTATTTAACAAAACAGAGGAAAAGACGAGAGAGTTTATTGATGAGAAAGTAAAAGAAGAGAAAATTTATC
CTTTTTACACATTAAAAGATTTTGTCGAAAGTCTAAAAAAACCAAGAAAAATTATACTTATAATAAAAGCAGGAACACCT
GTAGATGATGTGATAAACGAACTCTTATCGTATTTAGAAAAAGGGGATCTTATTGTTGACAGTGGGAATTCTTATTTTAT
GGATACTTCCAGGAGGTTAAAAGTTTTAAAAGAAAAGAATATTTTATTTTTAGGCATGGGAATTTCTGGTGGAGAGTATG
GTGCATTATATGGTCCTTCTTTAATGCCAGGTGGAACAAAAGAAGCTTATGAGTTGATAAAAGATGTACTTTTAAAAGTA
GCTGCAAAAACAGAAGATGGGCCTTGTTGTACGTATGTGGGCAACGATTCTGCAGGGCATTTTGTAAAAATGGTTCATAA
TGGTATTGAATATGCTATTATGCAATTGATTGCTGAAGTGTATGATTTTATGAGGAAAATATTGAATATGACTAATGAAG
AGATAGGGGATGTGTTTGAAAGGTGGAATCAGGAAGAACTTGATTCTTATTTAATGGAAATTTCTTATAAAATTATGAGA
TATAAAGACAAAGAAACTGGAGGATTTTTATTAGATTACATTTTAGATAAAGCAGAACAAAAAGGCACTGGAAAGTGGAC
TGCTCAAACTTCTTTGGATTTAGGAGTTCCTACACCAACATTGAATTTGGCGGTAGAGGCCAGAGTTATTTCTCATTACA
AGGAAGAAAGAAAAACTTTATCAAAATTATATTCGAAAGAAAAGAATACAATCTCTGTGAATAAAGAAGAAATGATAGAG
CATTTAAAAAAGACACTGCTTTTTGGAGTATTCATGTCATTTTCACAAGGATTATGGCTCATTTATGAAGCTTCAAAACA
ATATAATTATGGAGTAGACCTTAGCGAAATATTAAGAATTTGGAAAGGAGGCTGTATTATAAGAGCAAAAATTTTAGACT
TTTTGAGGGATATCATCAGAGAAAATGAAAAATATGCAAATCTTTTGCATAGTGATAAGTCTATAGAATTTATTAAGGAT
AAATTAAATTCTGTCTATCAAGTTCTAGAAATTGGAAGAAATTATAGAATACCTCTCATGATAATAAATTCTGCAGTTGA
TTATTATTTTGCTTTAACAGAGGAAAATCTTCCTGCAAATCTTATTCAAGCCCAACGTGACTTTTTTGGAGCTCATACTT
ATGAAAGAGTCGATAAAGAAGGAATATTCCACACAGAGTGGGAAAAATAA

Upstream 100 bases:

>100_bases
CAATTATAGAAGAAATGAATAGGACAAAAGGGAAAGGGTATAATTCAACAAAGCCTTTAAAAATATGCAAGTAAACTATT
TATATAATGGGAGGTAATGT

Downstream 100 bases:

>100_bases
GCCATGGAGAAGTTGCTCCATGGCTTTATAACTAAAAGAAATAGCATGATTGACTCGATGACAGTAATCTGCTATAATTT
AAGCGTTGAAAATTTGACTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MIKADIGLIGLGVMGQNLALNIARNGYAVSVFNKTEEKTREFIDEKVKEEKIYPFYTLKDFVESLKKPRKIILIIKAGTP
VDDVINELLSYLEKGDLIVDSGNSYFMDTSRRLKVLKEKNILFLGMGISGGEYGALYGPSLMPGGTKEAYELIKDVLLKV
AAKTEDGPCCTYVGNDSAGHFVKMVHNGIEYAIMQLIAEVYDFMRKILNMTNEEIGDVFERWNQEELDSYLMEISYKIMR
YKDKETGGFLLDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARVISHYKEERKTLSKLYSKEKNTISVNKEEMIE
HLKKTLLFGVFMSFSQGLWLIYEASKQYNYGVDLSEILRIWKGGCIIRAKILDFLRDIIRENEKYANLLHSDKSIEFIKD
KLNSVYQVLEIGRNYRIPLMIINSAVDYYFALTEENLPANLIQAQRDFFGAHTYERVDKEGIFHTEWEK

Sequences:

>Translated_469_residues
MIKADIGLIGLGVMGQNLALNIARNGYAVSVFNKTEEKTREFIDEKVKEEKIYPFYTLKDFVESLKKPRKIILIIKAGTP
VDDVINELLSYLEKGDLIVDSGNSYFMDTSRRLKVLKEKNILFLGMGISGGEYGALYGPSLMPGGTKEAYELIKDVLLKV
AAKTEDGPCCTYVGNDSAGHFVKMVHNGIEYAIMQLIAEVYDFMRKILNMTNEEIGDVFERWNQEELDSYLMEISYKIMR
YKDKETGGFLLDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARVISHYKEERKTLSKLYSKEKNTISVNKEEMIE
HLKKTLLFGVFMSFSQGLWLIYEASKQYNYGVDLSEILRIWKGGCIIRAKILDFLRDIIRENEKYANLLHSDKSIEFIKD
KLNSVYQVLEIGRNYRIPLMIINSAVDYYFALTEENLPANLIQAQRDFFGAHTYERVDKEGIFHTEWEK
>Mature_469_residues
MIKADIGLIGLGVMGQNLALNIARNGYAVSVFNKTEEKTREFIDEKVKEEKIYPFYTLKDFVESLKKPRKIILIIKAGTP
VDDVINELLSYLEKGDLIVDSGNSYFMDTSRRLKVLKEKNILFLGMGISGGEYGALYGPSLMPGGTKEAYELIKDVLLKV
AAKTEDGPCCTYVGNDSAGHFVKMVHNGIEYAIMQLIAEVYDFMRKILNMTNEEIGDVFERWNQEELDSYLMEISYKIMR
YKDKETGGFLLDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARVISHYKEERKTLSKLYSKEKNTISVNKEEMIE
HLKKTLLFGVFMSFSQGLWLIYEASKQYNYGVDLSEILRIWKGGCIIRAKILDFLRDIIRENEKYANLLHSDKSIEFIKD
KLNSVYQVLEIGRNYRIPLMIINSAVDYYFALTEENLPANLIQAQRDFFGAHTYERVDKEGIFHTEWEK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=45.7446808510638, Blast_Score=401, Evalue=1e-112,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=49.3589743589744, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=42.6751592356688, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321695, Length=455, Percent_Identity=44.3956043956044, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=44.078947368421, Blast_Score=388, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24639279, Length=467, Percent_Identity=43.0406852248394, Blast_Score=377, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53814; Mature: 53814

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKADIGLIGLGVMGQNLALNIARNGYAVSVFNKTEEKTREFIDEKVKEEKIYPFYTLKD
CCCCCCCEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
FVESLKKPRKIILIIKAGTPVDDVINELLSYLEKGDLIVDSGNSYFMDTSRRLKVLKEKN
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHCCC
ILFLGMGISGGEYGALYGPSLMPGGTKEAYELIKDVLLKVAAKTEDGPCCTYVGNDSAGH
EEEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHH
FVKMVHNGIEYAIMQLIAEVYDFMRKILNMTNEEIGDVFERWNQEELDSYLMEISYKIMR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YKDKETGGFLLDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARVISHYKEERKTL
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SKLYSKEKNTISVNKEEMIEHLKKTLLFGVFMSFSQGLWLIYEASKQYNYGVDLSEILRI
HHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHH
WKGGCIIRAKILDFLRDIIRENEKYANLLHSDKSIEFIKDKLNSVYQVLEIGRNYRIPLM
HCCCCEEHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IINSAVDYYFALTEENLPANLIQAQRDFFGAHTYERVDKEGIFHTEWEK
EECCHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIKADIGLIGLGVMGQNLALNIARNGYAVSVFNKTEEKTREFIDEKVKEEKIYPFYTLKD
CCCCCCCEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
FVESLKKPRKIILIIKAGTPVDDVINELLSYLEKGDLIVDSGNSYFMDTSRRLKVLKEKN
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHCCC
ILFLGMGISGGEYGALYGPSLMPGGTKEAYELIKDVLLKVAAKTEDGPCCTYVGNDSAGH
EEEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHH
FVKMVHNGIEYAIMQLIAEVYDFMRKILNMTNEEIGDVFERWNQEELDSYLMEISYKIMR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YKDKETGGFLLDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARVISHYKEERKTL
CCCCCCCCHHHHHHHHHHHCCCCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SKLYSKEKNTISVNKEEMIEHLKKTLLFGVFMSFSQGLWLIYEASKQYNYGVDLSEILRI
HHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHH
WKGGCIIRAKILDFLRDIIRENEKYANLLHSDKSIEFIKDKLNSVYQVLEIGRNYRIPLM
HCCCCEEHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IINSAVDYYFALTEENLPANLIQAQRDFFGAHTYERVDKEGIFHTEWEK
EECCHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]