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The map label for this gene is serA [H]

Identifier: 167038811

GI number: 167038811

Start: 135112

End: 136119

Strand: Direct

Name: serA [H]

Synonym: Teth514_0138

Alternate gene names: 167038811

Gene position: 135112-136119 (Clockwise)

Preceding gene: 167038810

Following gene: 167038812

Centisome position: 5.5

GC content: 37.6

Gene sequence:

>1008_bases
ATGGGTGTTAAAATTGCCATTGTAAATTCCAGCAGTTTTGGCAAGCATTTTCCTGAACATATTGAAAGGTTAAAAGCATT
AGGAGAAGTCGAAAGATTTGAACTTCCCCACGATATGAGAGGGAAGGCATTAGCGGAAAAGCTAATGGGGTATTCTGTAA
TAATTGCCAGTGTCAAGCCATATTACGATAAGGAGTTTTTTGAGCATAAAGACAAAACTCTTTTAATAACACGTCACGGC
ATAGGTTATGATACAATAGACATTAAAAGTGCTACTGAAAAAGGAGTTATTGTAACGAAAGTTGAAGGCATTGTAGAAAG
GGAAGCTGTAGCCGAAAACGCTATTGCACTTTTACTAGATGTTATGAAAAAAGTAAGGTCTGCCTCACTTAAAGTGAAAG
AAGGAAAGTGGGGGGAAAGAGCGAGCTTCATTGGATATGAAATAAAAGGCAAAGTTGCAGGAATTATAGGTATTGGAAAT
ATTGGAAGCAGAGTTTGTGAAATCCTGAAATATGGGTTTGGTGCTAAAGTAGTGGCTTATGACCCTAATCTTTCAGCGGA
AGAAATAGAAAAAAGGGGAGCAGAGCCTGTCACATTAGAGGAACTTTTAAAGAGGGCAGATATAATTTCTTTAAATGCTT
CGCTAAATCGCGACAATTATCACATTCTTTCTCATAAAGAATTTGCCATGATGAAAAAAGGTACATTTATTGTCAATACA
GCAAGAGGAGAACTTATAGACACAGAGGCTTTGATTAAGGCGTTAAAGGAAGGAATAGTTTTAGGAGCAGGGTTAGATGT
TATAGAAGGGGAACCTATTGACGAAAATCATCCTCTTTTGGCATTTGACAACGTCATAATAACGCCTCATACTTCTGCAT
ACACTTATGAATGCCTAAAAGGCATGGGGGACAAAGTGGTTTCTGATGTAGAGAAAGTTTTAAGAGGAGAAATACCTGAA
GGGGTAATAAATCCAGAAGTTTTGGAGGGTAGGCCATGGAAAATTTGA

Upstream 100 bases:

>100_bases
AGCAGGTTTAGCCTTATCAGGACTTAAGGAACCATCATAAAATTTAATATGACAGACAATACGTAATTCATTAGTAAATT
AAATTTGGGAGGCATAAAAA

Downstream 100 bases:

>100_bases
TTTTTTCTGTTGATATATAAATAAAGAAAGCAAATAACAACCATTTATTGGAAATTATTAACAAAAAAGCAATGATACAA
AAAATTAAATGTTACAATTA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDMRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHG
IGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAIALLLDVMKKVRSASLKVKEGKWGERASFIGYEIKGKVAGIIGIGN
IGSRVCEILKYGFGAKVVAYDPNLSAEEIEKRGAEPVTLEELLKRADIISLNASLNRDNYHILSHKEFAMMKKGTFIVNT
ARGELIDTEALIKALKEGIVLGAGLDVIEGEPIDENHPLLAFDNVIITPHTSAYTYECLKGMGDKVVSDVEKVLRGEIPE
GVINPEVLEGRPWKI

Sequences:

>Translated_335_residues
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDMRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHG
IGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAIALLLDVMKKVRSASLKVKEGKWGERASFIGYEIKGKVAGIIGIGN
IGSRVCEILKYGFGAKVVAYDPNLSAEEIEKRGAEPVTLEELLKRADIISLNASLNRDNYHILSHKEFAMMKKGTFIVNT
ARGELIDTEALIKALKEGIVLGAGLDVIEGEPIDENHPLLAFDNVIITPHTSAYTYECLKGMGDKVVSDVEKVLRGEIPE
GVINPEVLEGRPWKI
>Mature_334_residues
GVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDMRGKALAEKLMGYSVIIASVKPYYDKEFFEHKDKTLLITRHGI
GYDTIDIKSATEKGVIVTKVEGIVEREAVAENAIALLLDVMKKVRSASLKVKEGKWGERASFIGYEIKGKVAGIIGIGNI
GSRVCEILKYGFGAKVVAYDPNLSAEEIEKRGAEPVTLEELLKRADIISLNASLNRDNYHILSHKEFAMMKKGTFIVNTA
RGELIDTEALIKALKEGIVLGAGLDVIEGEPIDENHPLLAFDNVIITPHTSAYTYECLKGMGDKVVSDVEKVLRGEIPEG
VINPEVLEGRPWKI

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=269, Percent_Identity=33.0855018587361, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI145580578, Length=274, Percent_Identity=33.9416058394161, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4557499, Length=274, Percent_Identity=33.9416058394161, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=34.7490347490347, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=33.457249070632, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=33.457249070632, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI6912396, Length=293, Percent_Identity=27.9863481228669, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=30.6772908366534, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=33.4600760456274, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789279, Length=279, Percent_Identity=29.7491039426523, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17532191, Length=279, Percent_Identity=31.1827956989247, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=31.2741312741313, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=35.655737704918, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=314, Percent_Identity=29.2993630573248, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=299, Percent_Identity=29.4314381270903, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=225, Percent_Identity=29.3333333333333, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=31.3725490196078, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646446, Length=290, Percent_Identity=32.7586206896552, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=290, Percent_Identity=32.7586206896552, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=290, Percent_Identity=32.7586206896552, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=290, Percent_Identity=32.7586206896552, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=290, Percent_Identity=33.1034482758621, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19921140, Length=261, Percent_Identity=32.5670498084291, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=315, Percent_Identity=28.2539682539683, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=238, Percent_Identity=29.4117647058824, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=27.4509803921569, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=26.7716535433071, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585514, Length=246, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574282, Length=246, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574284, Length=246, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45551003, Length=246, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36967; Mature: 36836

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDMRGKALAEKLMGYSVIIASVKP
CCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCEEEEECCCC
YYDKEFFEHKDKTLLITRHGIGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAIALLLD
CHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
VMKKVRSASLKVKEGKWGERASFIGYEIKGKVAGIIGIGNIGSRVCEILKYGFGAKVVAY
HHHHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEEECHHHHHHHHHHHCCCCCEEEEE
DPNLSAEEIEKRGAEPVTLEELLKRADIISLNASLNRDNYHILSHKEFAMMKKGTFIVNT
CCCCCHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCEEEECCHHHHHHCCCCEEEEC
ARGELIDTEALIKALKEGIVLGAGLDVIEGEPIDENHPLLAFDNVIITPHTSAYTYECLK
CCCCEECHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEECCEEECCCCCHHHHHHHH
GMGDKVVSDVEKVLRGEIPEGVINPEVLEGRPWKI
CCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure 
GVKIAIVNSSSFGKHFPEHIERLKALGEVERFELPHDMRGKALAEKLMGYSVIIASVKP
CEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHCCCEEEEECCCC
YYDKEFFEHKDKTLLITRHGIGYDTIDIKSATEKGVIVTKVEGIVEREAVAENAIALLLD
CHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
VMKKVRSASLKVKEGKWGERASFIGYEIKGKVAGIIGIGNIGSRVCEILKYGFGAKVVAY
HHHHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEEECHHHHHHHHHHHCCCCCEEEEE
DPNLSAEEIEKRGAEPVTLEELLKRADIISLNASLNRDNYHILSHKEFAMMKKGTFIVNT
CCCCCHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCEEEECCHHHHHHCCCCEEEEC
ARGELIDTEALIKALKEGIVLGAGLDVIEGEPIDENHPLLAFDNVIITPHTSAYTYECLK
CCCCEECHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEECCEEECCCCCHHHHHHHH
GMGDKVVSDVEKVLRGEIPEGVINPEVLEGRPWKI
CCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]