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The map label for this gene is tmk

Identifier: 167038727

GI number: 167038727

Start: 56986

End: 57597

Strand: Direct

Name: tmk

Synonym: Teth514_0053

Alternate gene names: 167038727

Gene position: 56986-57597 (Clockwise)

Preceding gene: 167038726

Following gene: 167038728

Centisome position: 2.32

GC content: 35.13

Gene sequence:

>612_bases
ATGAAAGGGAAATTTATAAGCTTTGAAGGAATAGATGGATGCGGTAAGACTACTCAGATAAAATTTCTGGAGGAGTATCT
TTTAAAACAGGGTTATAATATTTTGGTATTAAGGGAGCCTGGAGGCACAAAAGTTGGAGAAAAAGTTAGAGATATTTTAT
TGGATAAAAATAATTTCATTTCTCCAGTCACAGAAATGCTTTTATACGCTTCTTCTAGGGCTCAGCTAGTGGAGGAGAAA
ATATTGCCGGCCATTGAGGAGGGTAAAATTGTACTCTTAGACCGCTTTGTGGATAGCTCTTATGTGTATCAGGGTTATGC
GAGGGGCTTAGGGATAGAAAAGGTTAAGGTAGTTAACGAAATAGCTACAATGGGGATTTTGCCTGATGTAACAATTTATA
TAGACATTACTCCTGAAGAAGCAATGAAAAGACGAGGCAAAAGAGAAGCAGACAGATTAGAGAGAGAAAGTTGGGATTTT
CATAAAAAAGTAAGAGAAGGGTATATTAAGCTAGTTAAAGAATTTCCTAAAAGGTTTGTATTTATAGACGGAATGCAAGA
GCTTATGAAGGTGCATAAAGACATAATTGATGTAGTAAAAAAATATTTGTAA

Upstream 100 bases:

>100_bases
AGCGCATAAAAAAAGATATGGTAAAATATATAAATGTATTATATAATAAAGGTATTAAGATATTAGGTCTTAAAAATAAC
AACCTATTGGTGTGTGAAAT

Downstream 100 bases:

>100_bases
GGAGGGCATAAGATGAAGTTAGTGTTAGCTATTGTGCAGGACGAGGATGTAAGAAGACTTATGGATGGTTTGACTGAGGG
AGGATTTAGTTTTACGAGAA

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MKGKFISFEGIDGCGKTTQIKFLEEYLLKQGYNILVLREPGGTKVGEKVRDILLDKNNFISPVTEMLLYASSRAQLVEEK
ILPAIEEGKIVLLDRFVDSSYVYQGYARGLGIEKVKVVNEIATMGILPDVTIYIDITPEEAMKRRGKREADRLERESWDF
HKKVREGYIKLVKEFPKRFVFIDGMQELMKVHKDIIDVVKKYL

Sequences:

>Translated_203_residues
MKGKFISFEGIDGCGKTTQIKFLEEYLLKQGYNILVLREPGGTKVGEKVRDILLDKNNFISPVTEMLLYASSRAQLVEEK
ILPAIEEGKIVLLDRFVDSSYVYQGYARGLGIEKVKVVNEIATMGILPDVTIYIDITPEEAMKRRGKREADRLERESWDF
HKKVREGYIKLVKEFPKRFVFIDGMQELMKVHKDIIDVVKKYL
>Mature_203_residues
MKGKFISFEGIDGCGKTTQIKFLEEYLLKQGYNILVLREPGGTKVGEKVRDILLDKNNFISPVTEMLLYASSRAQLVEEK
ILPAIEEGKIVLLDRFVDSSYVYQGYARGLGIEKVKVVNEIATMGILPDVTIYIDITPEEAMKRRGKREADRLERESWDF
HKKVREGYIKLVKEFPKRFVFIDGMQELMKVHKDIIDVVKKYL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_THEP3 (B0K7K7)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001666109.1
- ProteinModelPortal:   B0K7K7
- GeneID:   5874506
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_2150
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK900620
- BioCyc:   TPSE340099:TETH39_2150-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23440; Mature: 23440

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFISFEGIDGCGKTTQIKFLEEYLLKQGYNILVLREPGGTKVGEKVRDILLDKNNFI
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCH
SPVTEMLLYASSRAQLVEEKILPAIEEGKIVLLDRFVDSSYVYQGYARGLGIEKVKVVNE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHH
IATMGILPDVTIYIDITPEEAMKRRGKREADRLERESWDFHKKVREGYIKLVKEFPKRFV
HHHHCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
FIDGMQELMKVHKDIIDVVKKYL
EHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKGKFISFEGIDGCGKTTQIKFLEEYLLKQGYNILVLREPGGTKVGEKVRDILLDKNNFI
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCH
SPVTEMLLYASSRAQLVEEKILPAIEEGKIVLLDRFVDSSYVYQGYARGLGIEKVKVVNE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHH
IATMGILPDVTIYIDITPEEAMKRRGKREADRLERESWDFHKKVREGYIKLVKEFPKRFV
HHHHCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
FIDGMQELMKVHKDIIDVVKKYL
EHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA