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The map label for this gene is dnaX [H]

Identifier: 167038707

GI number: 167038707

Start: 37909

End: 39465

Strand: Direct

Name: dnaX [H]

Synonym: Teth514_0033

Alternate gene names: 167038707

Gene position: 37909-39465 (Clockwise)

Preceding gene: 167038706

Following gene: 167038708

Centisome position: 1.54

GC content: 31.86

Gene sequence:

>1557_bases
ATGTATCAGTCTTTATATAGGAAGTACAGGCCCAAAAGCTTTAAAGAGGTGGTGGGGCAAGAGCATATTGTAAAAACTTT
AAAAAATCAGATAAAACTTAATAAGATAGGACATGCTTATCTTTTTACAGGTACAAGAGGAACAGGAAAAACCAGTGTAG
CTAAGATTTTTGCAAAAGCAGTTAATTGTTTAAATAATACAGATGGAGAGCCTTGTAATTCTTGTGAGATTTGTCAAGCT
ATAAATAACAACACTACGATGGATGTTTTAGAGATTGATGCTGCGTCTAATAACAGTGTAAATGATGTAAGAGAATTGAG
AGAGTCTGTAATTTACGCTCCTTCTCAAGCTAAGTACAAAGTATATATAATTGATGAAGTGCATATGCTTTCTACAGGGG
CTTTTAATGCTCTTTTAAAAACGTTGGAAGAACCTCCTCCTCATGTGATTTTTATTCTTGCTACTACTGAACCGGATAAA
TTGCCTGATACTATTTTATCAAGGTGTCAAAGGTTTGACTTTAAAAGAATACCTACGCGGTTAATTGCTCAAAATCTTGA
TAGAATTTGCAATGACAGTGGAATAAAAATCGAAGAAAAGGGACTTAAAACTATTGCCATCTATGGAAATGGTTCTATGA
GAGATGCGATAAGTCTACTAGAACAATGTGCTTCTTACAAAGAAGGCCTTATAACCTATGAAGATGTATGCGAAATGTTA
GGTGTAGCTAATGATGAAGTGTTATTTTCCCTTTTGGATTACATGAATGCTAAAGATGTAGCAGCTTCATTGAAACAATT
AGATAAAATTTTGTCTTATGGAATAGACGTGGGAAATTTTTTAAAATCCTTAACTTATATTTTGAGAGATATGGTGCTTT
ACAAAACAGGAGGAGAAGAATTAAAAGAAATTTTGTATAGCGATGTAGAAACTATAAAAGAAAGAGTACAAAACTTTGGT
ACAGCTTTTTTGACTAACGCTTTAGAAAAATTTACAAATCTGCAAAAAGAAGTTAGATATGCTATATCTCCGTTAACCCT
CTTAGAAGTAACTATTTTGAGGTTGATAAAACCGGAAATTTCTTACGATATGATGAGTTTGTTAGCAAGAGTAGAACAAA
TAGAAGACAAATTAGAAAAAGGCCAATTTTTTTTGAAGGAAGAAAAAAAAGAAGTCGAAAATAAGAAGATAAATATTTCG
CTAGAAAAAGAAGAAAACGTGACACCGCAAATAGTACAGCAAGAGGATATAGATCTAGAAAAGGTGTGGGCTGAAGTAAA
AGAAATGATAAAAAAAGGAAGAATAGCTTTGTATGCCTTTATAGAAAAAGGGACTCCTTATTTAAAAAAAGGAACAATTG
TGGTAGAATATCCTGAAGAATATGCTTTATTAAAGGAGGAATTGAGCAAAGCGGAAAACAAAAGTTTTATTGAAGGAATA
TTAAAAGAACTAGTTGGGAAGGCAATTCCTTTAAAGTTTGAATTAAGAAAAAATGAAGAGGAATTACTTGTACAGCAAGT
TAAAGAGTTTTTTGGTGAAGATATAGAGATAATATAA

Upstream 100 bases:

>100_bases
CTAGAAGAGATAAAAAATCAAGTTTTTTCAAATGCTTCTTAAGAGATATAGAAATATCTCTTTTTTTTTGTTACAATTGA
ATATAACGAGGTGTTAAAGT

Downstream 100 bases:

>100_bases
TTTTCACAAATCATTTAAAAAAGCATATAAATATTTTTAGAATAAAATTTAGGAGGTTATAGTGTTATGGCAAAAGGCGG
ATTTCCGGGCGGGTTTAATA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MYQSLYRKYRPKSFKEVVGQEHIVKTLKNQIKLNKIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNNTDGEPCNSCEICQA
INNNTTMDVLEIDAASNNSVNDVRELRESVIYAPSQAKYKVYIIDEVHMLSTGAFNALLKTLEEPPPHVIFILATTEPDK
LPDTILSRCQRFDFKRIPTRLIAQNLDRICNDSGIKIEEKGLKTIAIYGNGSMRDAISLLEQCASYKEGLITYEDVCEML
GVANDEVLFSLLDYMNAKDVAASLKQLDKILSYGIDVGNFLKSLTYILRDMVLYKTGGEELKEILYSDVETIKERVQNFG
TAFLTNALEKFTNLQKEVRYAISPLTLLEVTILRLIKPEISYDMMSLLARVEQIEDKLEKGQFFLKEEKKEVENKKINIS
LEKEENVTPQIVQQEDIDLEKVWAEVKEMIKKGRIALYAFIEKGTPYLKKGTIVVEYPEEYALLKEELSKAENKSFIEGI
LKELVGKAIPLKFELRKNEEELLVQQVKEFFGEDIEII

Sequences:

>Translated_518_residues
MYQSLYRKYRPKSFKEVVGQEHIVKTLKNQIKLNKIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNNTDGEPCNSCEICQA
INNNTTMDVLEIDAASNNSVNDVRELRESVIYAPSQAKYKVYIIDEVHMLSTGAFNALLKTLEEPPPHVIFILATTEPDK
LPDTILSRCQRFDFKRIPTRLIAQNLDRICNDSGIKIEEKGLKTIAIYGNGSMRDAISLLEQCASYKEGLITYEDVCEML
GVANDEVLFSLLDYMNAKDVAASLKQLDKILSYGIDVGNFLKSLTYILRDMVLYKTGGEELKEILYSDVETIKERVQNFG
TAFLTNALEKFTNLQKEVRYAISPLTLLEVTILRLIKPEISYDMMSLLARVEQIEDKLEKGQFFLKEEKKEVENKKINIS
LEKEENVTPQIVQQEDIDLEKVWAEVKEMIKKGRIALYAFIEKGTPYLKKGTIVVEYPEEYALLKEELSKAENKSFIEGI
LKELVGKAIPLKFELRKNEEELLVQQVKEFFGEDIEII
>Mature_518_residues
MYQSLYRKYRPKSFKEVVGQEHIVKTLKNQIKLNKIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNNTDGEPCNSCEICQA
INNNTTMDVLEIDAASNNSVNDVRELRESVIYAPSQAKYKVYIIDEVHMLSTGAFNALLKTLEEPPPHVIFILATTEPDK
LPDTILSRCQRFDFKRIPTRLIAQNLDRICNDSGIKIEEKGLKTIAIYGNGSMRDAISLLEQCASYKEGLITYEDVCEML
GVANDEVLFSLLDYMNAKDVAASLKQLDKILSYGIDVGNFLKSLTYILRDMVLYKTGGEELKEILYSDVETIKERVQNFG
TAFLTNALEKFTNLQKEVRYAISPLTLLEVTILRLIKPEISYDMMSLLARVEQIEDKLEKGQFFLKEEKKEVENKKINIS
LEKEENVTPQIVQQEDIDLEKVWAEVKEMIKKGRIALYAFIEKGTPYLKKGTIVVEYPEEYALLKEELSKAENKSFIEGI
LKELVGKAIPLKFELRKNEEELLVQQVKEFFGEDIEII

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=308, Percent_Identity=26.6233766233766, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI31881687, Length=308, Percent_Identity=26.6233766233766, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI194306571, Length=265, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI194306567, Length=265, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI6677723, Length=265, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786676, Length=359, Percent_Identity=38.7186629526462, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI1787119, Length=239, Percent_Identity=26.3598326359833, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=225, Percent_Identity=28, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541988, Length=305, Percent_Identity=23.6065573770492, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=220, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=323, Percent_Identity=24.1486068111455, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=307, Percent_Identity=25.0814332247557, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=256, Percent_Identity=22.65625, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859927, Length=259, Percent_Identity=27.7992277992278, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647857, Length=273, Percent_Identity=24.9084249084249, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 59061; Mature: 59061

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQSLYRKYRPKSFKEVVGQEHIVKTLKNQIKLNKIGHAYLFTGTRGTGKTSVAKIFAKA
CCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
VNCLNNTDGEPCNSCEICQAINNNTTMDVLEIDAASNNSVNDVRELRESVIYAPSQAKYK
HHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHEECCCCCCEE
VYIIDEVHMLSTGAFNALLKTLEEPPPHVIFILATTEPDKLPDTILSRCQRFDFKRIPTR
EEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHCCHH
LIAQNLDRICNDSGIKIEEKGLKTIAIYGNGSMRDAISLLEQCASYKEGLITYEDVCEML
HHHHHHHHHHCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVANDEVLFSLLDYMNAKDVAASLKQLDKILSYGIDVGNFLKSLTYILRDMVLYKTGGEE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
LKEILYSDVETIKERVQNFGTAFLTNALEKFTNLQKEVRYAISPLTLLEVTILRLIKPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
SYDMMSLLARVEQIEDKLEKGQFFLKEEKKEVENKKINISLEKEENVTPQIVQQEDIDLE
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCHH
KVWAEVKEMIKKGRIALYAFIEKGTPYLKKGTIVVEYPEEYALLKEELSKAENKSFIEGI
HHHHHHHHHHHHCCEEEEEEECCCCCCEECCEEEEECCHHHHHHHHHHHHHCCHHHHHHH
LKELVGKAIPLKFELRKNEEELLVQQVKEFFGEDIEII
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYQSLYRKYRPKSFKEVVGQEHIVKTLKNQIKLNKIGHAYLFTGTRGTGKTSVAKIFAKA
CCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
VNCLNNTDGEPCNSCEICQAINNNTTMDVLEIDAASNNSVNDVRELRESVIYAPSQAKYK
HHHHCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHEECCCCCCEE
VYIIDEVHMLSTGAFNALLKTLEEPPPHVIFILATTEPDKLPDTILSRCQRFDFKRIPTR
EEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCHHHCCHH
LIAQNLDRICNDSGIKIEEKGLKTIAIYGNGSMRDAISLLEQCASYKEGLITYEDVCEML
HHHHHHHHHHCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVANDEVLFSLLDYMNAKDVAASLKQLDKILSYGIDVGNFLKSLTYILRDMVLYKTGGEE
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
LKEILYSDVETIKERVQNFGTAFLTNALEKFTNLQKEVRYAISPLTLLEVTILRLIKPEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
SYDMMSLLARVEQIEDKLEKGQFFLKEEKKEVENKKINISLEKEENVTPQIVQQEDIDLE
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCHH
KVWAEVKEMIKKGRIALYAFIEKGTPYLKKGTIVVEYPEEYALLKEELSKAENKSFIEGI
HHHHHHHHHHHHCCEEEEEEECCCCCCEECCEEEEECCHHHHHHHHHHHHHCCHHHHHHH
LKELVGKAIPLKFELRKNEEELLVQQVKEFFGEDIEII
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]