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The map label for this gene is gmk [H]

Identifier: 16273629

GI number: 16273629

Start: 1829263

End: 1829889

Strand: Reverse

Name: gmk [H]

Synonym: HI1743

Alternate gene names: 16273629

Gene position: 1829889-1829263 (Counterclockwise)

Preceding gene: NA

Following gene: 16273628

Centisome position: 99.99

GC content: 36.04

Gene sequence:

>627_bases
ATGTCTCAAGGTAATCTTTATATTTTATCTGCACCAAGTGGCGCAGGAAAATCTTCATTAATTTCAGCGTTATTGGCATC
AGATAGCTCAACTCAAAAAATGGTTTCTGTGTCACATACGACCCGTGCCCCACGCCCGGGTGAAGTTGAAGGCGTACACT
ATTATTTTGTATCAAAAGAAGAGTTTGAATCACTCATTGAGCAAGATTTATTTCTAGAATATGCCAAAGTTTTTGGTGGC
AATTATTATGGAACCTCTTTACCTGCGATTGAGGAAAATTTAGCAAAAGGCATTGATGTATTTTTAGATATTGATTGGCA
GGGCGCCCAACAAATCCGTAAAAAAGTGCCTTCAGTAAAAAGCATTTTTATTTTACCGCCTTCATTGCCTGAATTAGAGC
GTCGTTTAATTGGTCGAGGGCAAGATAGTGAAGAGGTTATCGCTGAACGAATGTCAAAAGCGATGAGTGAAATTTCGCAT
TATGACGAATATGATTATGTCATTGTGAATGATGATTTTGAGAAAACATTAAAAGATTTACAAAGTATTTTGCAATCGGA
ACGCTTAACTAAAGATTATCAACAAAAACAAAATGCAATGTTAATTCAACAGCTACTAGCAAAATAG

Upstream 100 bases:

>100_bases
AGAATGAAAAAGTACCGTAAAAAATCACCGCACTTTTGATGATTTTTTATAGAGAAATCTGCATAATAGACTGAAATTGT
CAGAGAAGGTTAAATATTCT

Downstream 100 bases:

>100_bases
GGCGAAATTGAGTATTATAACGCCCTTTCAATAGAGTAATTTTTGACAAATCGGAGTAAATTATGGCTCGTGTTACTGTG
CAAGATGCAGTAGAAAAAAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISH
YDEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK

Sequences:

>Translated_208_residues
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGG
NYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISH
YDEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK
>Mature_207_residues
SQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKEEFESLIEQDLFLEYAKVFGGN
YYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVKSIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISHY
DEYDYVIVNDDFEKTLKDLQSILQSERLTKDYQQKQNAMLIQQLLAK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=40.1041666666667, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=40.1041666666667, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=40.1041666666667, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI111154074, Length=180, Percent_Identity=32.2222222222222, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=30.2564102564103, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=31.638418079096, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI52630447, Length=193, Percent_Identity=28.4974093264249, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI21536464, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21361598, Length=203, Percent_Identity=27.0935960591133, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=64.7342995169082, Blast_Score=279, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=38.0434782608696, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=38.0434782608696, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557440, Length=184, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=140, Percent_Identity=33.5714285714286, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=25.9668508287293, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=152, Percent_Identity=28.2894736842105, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=43.3526011560694, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=29.8342541436464, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161077626, Length=175, Percent_Identity=30.2857142857143, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=29.8342541436464, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=29.8342541436464, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=29.8342541436464, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=29.8342541436464, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23419; Mature: 23288

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKE
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECHH
EFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISHYDEYDYVIVNDDFEKTLKDL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
QSILQSERLTKDYQQKQNAMLIQQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQGNLYILSAPSGAGKSSLISALLASDSSTQKMVSVSHTTRAPRPGEVEGVHYYFVSKE
CCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECHH
EFESLIEQDLFLEYAKVFGGNYYGTSLPAIEENLAKGIDVFLDIDWQGAQQIRKKVPSVK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCC
SIFILPPSLPELERRLIGRGQDSEEVIAERMSKAMSEISHYDEYDYVIVNDDFEKTLKDL
EEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
QSILQSERLTKDYQQKQNAMLIQQLLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA