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The map label for this gene is dld

Identifier: 16273537

GI number: 16273537

Start: 1714592

End: 1716286

Strand: Reverse

Name: dld

Synonym: HI1649

Alternate gene names: 16273537

Gene position: 1716286-1714592 (Counterclockwise)

Preceding gene: 16273539

Following gene: 16273655

Centisome position: 93.78

GC content: 39.41

Gene sequence:

>1695_bases
ATGTCTGTTCAACAACTCATTTCACGACTGACCGATATTGTTGGCTCTCGTTATATTATTACTGATCCAACTAAAACAGA
AGCTTATCGAAGTGGTTATCGATTTGGAACAGGAAACGCCCTAGCTGTAGTTCGCCCTGCCACTCTACTTGAGTTTTGGA
ACATTGTAAAAGTTTGCGTTGAACATGATGTTATTGTTATAAACCAAGCGGCGAATACAGGTTTAACTGGTGGCTCTACA
CCAGATGGCAATGATTATGATCGCGATATTGTCGTCATCAATACAATGCGAATTGACGGAATCCAACTCATCAATAACGC
TTCCCAAGTTATTTGCTTACCAGGCTCTACACTCAATGAATTAGAAAATCAACTTAAACCGTTTGGTCGTGAACCCCACT
CTGTTATTGGCTCATCTTGCATTGGCGCATCAGTTATTGGTGGGATTTGTAACAACTCAGGTGGAGCATTAGTTCAACGT
GGACCAGCCTATACAGAAATGGCACTTTACGCTCAACTTAATGAAAAAGGTGAATTAGAACTAAAAAATCATTTAGGCAT
TGATTTAGGAGAAACTCCTGAAGAAATTTTAACTAATCTACAAGAAAAACGTTATCAGGTTAAAGATATTCGACAAGATT
GCGGACATGGTCACGACCATTACTACTGCAACTATGTTCGTCAAGTTGATGAAGGCTCCCCTGCTCGTTTTAATGCCGAC
CCAGCTCGCCACTATGAAGCCTCAGGCTGTGCAGGAAAACTTGCTGTCTTTGCGGTTCGTTTAGACACCTTTCCGCTTGA
AAAAGAGACGGCTGTTTTCTATATCGGCACCAATCAAACTTCTGTGTTGAGCGATATTCGTCGCCACATGTTAGTAAACT
TCGAAGTGCTACCCATTTCAGGTGAATATATCCATCGTGATGCATTTGACATCGCAGCAAAATATGGCAAAGATACCTTT
TGGGTCATTAAAAAGTTTGGTACACATTGGCTACCAAAACTCTTTTCCTTAAAATCAAACGTGGATCGCATCGGCAAAAA
ATTCTTCTTTTTACCACAACATTTAAGCGATAAATTTATGCAAACTGTGTCTAAATTCATCCCAGAACATCTTCCACAAA
GCTTATGGGATTATCGCAACAAATACGAGCATCACTTAATTATCAAAATGGGTGGAAAAGGCATTCAAGAAGCCCGTGAA
TATTTGGAATCCTACATTGCAGATGGCTCAAAAGGTGGCTATTTTGAATGTAATGCAATCGAAACCCAAGCAGCAATGCT
TCATCGTTTCGCTGTTGCAAGTGCTGCAATTCGTTATCGTGCAATTCACGAAAAAGAAGTAGAAGAAATAGTTGCTTTAG
ATGTTGCATTACGTCGCAATGATCAAGATTGGTTTGAAGTGTTACCGCCAGAAATTGATAACAGAATTATCTCTAAACTT
TACTACGGACATTTTATGTGCCATGTCTTTCACCAAGATTACATTGTAAAAAAAGGTTATGATTATGAAGAACTAGAATA
CGAAATGTTGAAATTACTTGACAAGCGTGGTGCGCAATACCCAGCCGAACACAATGTAGGGCATTTATACGAGGCTAAAC
CAACCTTGAGAAAATTCTATAAAGAGTTGGATCCAACCAATAGCTTTAATCCAGGTATTGGTAAAACGACGAGGAAAAAA
TACTGGGCGGAATAA

Upstream 100 bases:

>100_bases
AATTCCAAAAAAAACACCGATTAAAGCCTAAAATATCCTTATCCAAATGGGAATTATTCTGTTATAGTGCTATTAATTCT
TATTACAAGAGGATAATAAA

Downstream 100 bases:

>100_bases
ACCTCTAAAATGCAAACAAGATGTCAAATGTGACCGCTTGTTTATTATTTCCTCTTCTTAGATAGAGCCAACTCATCAAA
ATAAGGTCAGCAAATTATCT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGST
PDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQR
GPAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNAD
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDTF
WVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEARE
YLESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKK
YWAE

Sequences:

>Translated_564_residues
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGST
PDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQR
GPAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNAD
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDTF
WVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEARE
YLESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKK
YWAE
>Mature_563_residues
SVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGSTP
DGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRG
PAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNADP
ARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDTFW
VIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREY
LESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKLY
YGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKKY
WAE

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1788454, Length=561, Percent_Identity=59.7147950089127, Blast_Score=718, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LDHD_HAEIN (P45295)

Other databases:

- EMBL:   L42023
- PIR:   I64134
- RefSeq:   NP_439791.1
- ProteinModelPortal:   P45295
- SMR:   P45295
- GeneID:   950490
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1649
- NMPDR:   fig|71421.1.peg.1563
- TIGR:   HI_1649
- HOGENOM:   HBG289102
- OMA:   LYYGHFF
- ProtClustDB:   PRK11183
- BioCyc:   HINF71421:HI_1649-MONOMER
- BRENDA:   1.1.1.28
- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.70.610
- Gene3D:   G3DSA:3.30.1370.20
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.30.465.20
- PIRSF:   PIRSF000101

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb; SSF55103 FAD-binding_2; SSF56176 FAD-binding_2

EC number: =1.1.1.28

Molecular weight: Translated: 64127; Mature: 63995

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51387 FAD_PCMH; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCV
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EHDVIVINQAANTGLTGGSTPDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNE
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCCEEEEECCCHHHH
LENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYAQLNEKGELE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCEE
LKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNAD
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPIS
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEEEECC
GEYIHRDAFDIAAKYGKDTFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFM
CCHHHHHHHHHHHHHCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHH
QTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGSKGGYFECNAI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KELDPTNSFNPGIGKTTRKKYWAE
HHCCCCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
SVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCV
CHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
EHDVIVINQAANTGLTGGSTPDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNE
CCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCCEEEEECCCHHHH
LENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYAQLNEKGELE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCEE
LKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNAD
EHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCC
PARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPIS
HHHCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEEEECC
GEYIHRDAFDIAAKYGKDTFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFM
CCHHHHHHHHHHHHHCCCCEEHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHH
QTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGSKGGYFECNAI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KELDPTNSFNPGIGKTTRKKYWAE
HHCCCCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800