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The map label for this gene is sapD

Identifier: 16273530

GI number: 16273530

Start: 1706506

End: 1707555

Strand: Direct

Name: sapD

Synonym: HI1641

Alternate gene names: 16273530

Gene position: 1706506-1707555 (Clockwise)

Preceding gene: 16273529

Following gene: 16273531

Centisome position: 93.24

GC content: 36.57

Gene sequence:

>1050_bases
ATGGCACTTTTAGACATTTGTAACCTCAATATTGAAATTCAAACCTCCAATGGACGTATAAAAATTGTAGATGGCGTCAA
TCTTTCCCTTAACGAAGGGGAAATCAGTGGATTAGTTGGCGAATCAGGCTCAGGAAAAAGCTTAATCGCTAAAGTCATTT
GTAATGCAATCAAAGAAAATTGGATTATTACTGCCGATCGCTTTCGTTTTCACGATGTCGAATTACTTAAACTCAGTCCC
AATAAACGCCGAAAGTTAGTGGGTAAAGAAATATCCATGATTTTCCAAAATCCCTTATCTTGCCTTGATCCAAGTCGAAA
AATAGGGAAACAACTAATCCAAAATATTCCTAATTGGACATTTAAAAATAAATGGTGGAAATGGTTTGGGTGGAAAAAAA
GACGTGCTATTGAATTGTTACATCGCGTAGGAATTAAAGATCATCGTGATATTATGGCAAGCTATCCTAACGAACTGACA
GAAGGCGAAGGACAAAAAGTTATGATCGCAATGGCTGTCGCTAATCAGCCACGTTTATTAATCGCAGATGAACCAACAAA
TGCATTAGAATCAACCACTGCCCTACAAGTTTTTCGTTTACTTTCCAGTATGAACCAAAATCAGGGAACAACAATTTTAC
TTACGAGTAACGATATTAAAAGTATTAGTGAATGGTGCGATCAAATTTCAGTGCTTTATTGTGGGCAAAATACCGAATCT
GCCCCGACTGAAATATTAATCGAAAGTCCCCATCATCCTTATACCCAAGCCTTAATTAATGCAGTACCCGATTTTACTCA
ACCTTTGGGGTTTAAAACTAAATTGGGTACGTTAGAAGGCACCGCGCCTATTTTAGAGCAAATGCCAATTGGCTGTCGTC
TTGGCCCAAGATGCCCTTTTGCACAAAAAAAATGTATGGAAAAACCAAGACGATTGAAAATAAAACAACACGAATTTTCT
TGTCATTATCCTATTAATTTACGAGAAAAAAATTTCAAAGAAAAAACAACCGCCACCCCTTTTATACTTAATTGCAAAGG
AAATGAATAA

Upstream 100 bases:

>100_bases
AGTACTTTTACCCGGTTTCGCTATTATTTTTACTATTTTATTAAGTATTATTTTCAGTAATGGCTTAACTAAAGCCATCA
ATCAACATCAAGAATAGCCT

Downstream 100 bases:

>100_bases
TGCCCTTATTACAAGTGGAAGATTTAACTAAAACTTTTAAAGGTCACGCCAGTTTATTTGGTCGAAATCAATTCAATGCA
GTGGATAAAGTGAGTTTTAC

Product: peptide ABC transporter ATP-binding protein

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MALLDICNLNIEIQTSNGRIKIVDGVNLSLNEGEISGLVGESGSGKSLIAKVICNAIKENWIITADRFRFHDVELLKLSP
NKRRKLVGKEISMIFQNPLSCLDPSRKIGKQLIQNIPNWTFKNKWWKWFGWKKRRAIELLHRVGIKDHRDIMASYPNELT
EGEGQKVMIAMAVANQPRLLIADEPTNALESTTALQVFRLLSSMNQNQGTTILLTSNDIKSISEWCDQISVLYCGQNTES
APTEILIESPHHPYTQALINAVPDFTQPLGFKTKLGTLEGTAPILEQMPIGCRLGPRCPFAQKKCMEKPRRLKIKQHEFS
CHYPINLREKNFKEKTTATPFILNCKGNE

Sequences:

>Translated_349_residues
MALLDICNLNIEIQTSNGRIKIVDGVNLSLNEGEISGLVGESGSGKSLIAKVICNAIKENWIITADRFRFHDVELLKLSP
NKRRKLVGKEISMIFQNPLSCLDPSRKIGKQLIQNIPNWTFKNKWWKWFGWKKRRAIELLHRVGIKDHRDIMASYPNELT
EGEGQKVMIAMAVANQPRLLIADEPTNALESTTALQVFRLLSSMNQNQGTTILLTSNDIKSISEWCDQISVLYCGQNTES
APTEILIESPHHPYTQALINAVPDFTQPLGFKTKLGTLEGTAPILEQMPIGCRLGPRCPFAQKKCMEKPRRLKIKQHEFS
CHYPINLREKNFKEKTTATPFILNCKGNE
>Mature_348_residues
ALLDICNLNIEIQTSNGRIKIVDGVNLSLNEGEISGLVGESGSGKSLIAKVICNAIKENWIITADRFRFHDVELLKLSPN
KRRKLVGKEISMIFQNPLSCLDPSRKIGKQLIQNIPNWTFKNKWWKWFGWKKRRAIELLHRVGIKDHRDIMASYPNELTE
GEGQKVMIAMAVANQPRLLIADEPTNALESTTALQVFRLLSSMNQNQGTTILLTSNDIKSISEWCDQISVLYCGQNTESA
PTEILIESPHHPYTQALINAVPDFTQPLGFKTKLGTLEGTAPILEQMPIGCRLGPRCPFAQKKCMEKPRRLKIKQHEFSC
HYPINLREKNFKEKTTATPFILNCKGNE

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides

COG id: COG4170

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Escherichia coli, GI1787548, Length=330, Percent_Identity=62.7272727272727, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789963, Length=328, Percent_Identity=37.5, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1787759, Length=308, Percent_Identity=36.038961038961, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI48994883, Length=308, Percent_Identity=34.4155844155844, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1787500, Length=330, Percent_Identity=32.1212121212121, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI145693107, Length=269, Percent_Identity=30.8550185873606, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788506, Length=266, Percent_Identity=33.4586466165414, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789962, Length=280, Percent_Identity=30, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787758, Length=306, Percent_Identity=28.7581699346405, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789890, Length=254, Percent_Identity=29.1338582677165, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786398, Length=256, Percent_Identity=30.078125, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787547, Length=266, Percent_Identity=26.6917293233083, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081834, Length=236, Percent_Identity=30.0847457627119, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994997, Length=237, Percent_Identity=26.5822784810127, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789891, Length=245, Percent_Identity=28.1632653061224, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790544, Length=232, Percent_Identity=28.448275862069, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789032, Length=251, Percent_Identity=25.4980079681275, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787105, Length=220, Percent_Identity=26.8181818181818, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787029, Length=248, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788450, Length=239, Percent_Identity=25.9414225941423, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788225, Length=264, Percent_Identity=25.3787878787879, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789672, Length=265, Percent_Identity=26.0377358490566, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786345, Length=226, Percent_Identity=25.2212389380531, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790190, Length=229, Percent_Identity=29.6943231441048, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081791, Length=306, Percent_Identity=23.8562091503268, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788644, Length=263, Percent_Identity=26.9961977186312, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786319, Length=236, Percent_Identity=23.728813559322, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790525, Length=231, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786563, Length=217, Percent_Identity=27.1889400921659, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAPD_HAEIN (P45288)

Other databases:

- EMBL:   L42023
- PIR:   D64134
- RefSeq:   NP_439783.1
- ProteinModelPortal:   P45288
- GeneID:   950483
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1641
- NMPDR:   fig|71421.1.peg.1555
- TIGR:   HI_1641
- HOGENOM:   HBG758042
- OMA:   MSKWADR
- ProtClustDB:   CLSK2517332
- BioCyc:   HINF71421:HI_1641-MONOMER
- InterPro:   IPR003439
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563
- SMART:   SM00382
- TIGRFAMs:   TIGR01727

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY

EC number: NA

Molecular weight: Translated: 39478; Mature: 39347

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDICNLNIEIQTSNGRIKIVDGVNLSLNEGEISGLVGESGSGKSLIAKVICNAIKEN
CCEEEEECCEEEEEECCCEEEEEECCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCC
WIITADRFRFHDVELLKLSPNKRRKLVGKEISMIFQNPLSCLDPSRKIGKQLIQNIPNWT
EEEEECCEEECCEEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCC
FKNKWWKWFGWKKRRAIELLHRVGIKDHRDIMASYPNELTEGEGQKVMIAMAVANQPRLL
CCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCEEE
IADEPTNALESTTALQVFRLLSSMNQNQGTTILLTSNDIKSISEWCDQISVLYCGQNTES
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCEEEEEECCCCCC
APTEILIESPHHPYTQALINAVPDFTQPLGFKTKLGTLEGTAPILEQMPIGCRLGPRCPF
CCCEEEEECCCCHHHHHHHHHCCCHHCCCCCCEECCCCCCCHHHHHCCCCCCCCCCCCCH
AQKKCMEKPRRLKIKQHEFSCHYPINLREKNFKEKTTATPFILNCKGNE
HHHHHHCCCHHCEEEECCCEEECCCCCCCCCCCHHCCCCCEEEEECCCC
>Mature Secondary Structure 
ALLDICNLNIEIQTSNGRIKIVDGVNLSLNEGEISGLVGESGSGKSLIAKVICNAIKEN
CEEEEECCEEEEEECCCEEEEEECCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCC
WIITADRFRFHDVELLKLSPNKRRKLVGKEISMIFQNPLSCLDPSRKIGKQLIQNIPNWT
EEEEECCEEECCEEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCC
FKNKWWKWFGWKKRRAIELLHRVGIKDHRDIMASYPNELTEGEGQKVMIAMAVANQPRLL
CCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCEEE
IADEPTNALESTTALQVFRLLSSMNQNQGTTILLTSNDIKSISEWCDQISVLYCGQNTES
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCEEEEEECCCCCC
APTEILIESPHHPYTQALINAVPDFTQPLGFKTKLGTLEGTAPILEQMPIGCRLGPRCPF
CCCEEEEECCCCHHHHHHHHHCCCHHCCCCCCEECCCCCCCHHHHHCCCCCCCCCCCCCH
AQKKCMEKPRRLKIKQHEFSCHYPINLREKNFKEKTTATPFILNCKGNE
HHHHHHCCCHHCEEEECCCEEECCCCCCCCCCCHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800