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The map label for this gene is sapC

Identifier: 16273529

GI number: 16273529

Start: 1705615

End: 1706502

Strand: Direct

Name: sapC

Synonym: HI1640

Alternate gene names: 16273529

Gene position: 1705615-1706502 (Clockwise)

Preceding gene: 16273528

Following gene: 16273530

Centisome position: 93.2

GC content: 34.8

Gene sequence:

>888_bases
ATGCAAAATAAAGAACCTGATGAATTCCGCGAAAGCACCTCAATCTTTCAAATTTGGTTACGCTTTCGTCAAAATACCAT
CGCACTTTTTAGCTTTTATTTATTAATCGCATTAATTTTTACCGCACTTTTTGCTAGTTATCTTGCACCTTATGCTGATA
ATCGACAATTTATTGGGCAAGAATTAATGCCTCCATCTTGGGTAGATAGAGGAAAAATTGCTTTTTTCTTTGGTACTGAT
GATTTAGGTCGCGACATATTAAGTCGTTTAATTATGGGTACTCGTTATACCTTAGGTTCTGCTTTACTGGTTGTCTTTTC
AGTGGCAATAATAGGCGGCGCACTAGGAATTATTGCAGGACTACTGAAAGGTATTAAAGCTCGTTTTGTCGGGCATATTT
TTGATGCTTTTTTATCGTTACCTATTCTATTAATTGCCGTTGTTATTTCAACATTAATGGAACCAAGTTTATGGAATGCA
ATGTTTGCTACGCTATTAGCGATTTTGCCTTATTTCATTCACACTATCTATCGTGCTATTCAAAAAGAATTAGAAAAGGA
TTATGTTGTAATGCTAAAACTTGAAGGCATTTCCAATCAAGCCTTATTAAAAAGCACTATTTTACCGAATATTACTGTTA
TTTATATTCAAGAAGTGGCTCGTGCTTTTGTGATAGCCGTGTTGGATATTAGCGCGTTAAGTTTTATTTCTCTTGGTGCA
CAACGACCTACACCAGAATGGGGGGCAATGATAAAAGACTCTTTGGAACTACTTTATCTTGCACCTTGGACAGTACTTTT
ACCCGGTTTCGCTATTATTTTTACTATTTTATTAAGTATTATTTTCAGTAATGGCTTAACTAAAGCCATCAATCAACATC
AAGAATAG

Upstream 100 bases:

>100_bases
GCCGCAGGTGTAATTGTTATTGGTGTATGTATTATTTTGATTGATACATTCACTAAAATATTCACTTTTATACTCGATCC
ATTTAAAAAGAAAGGTTGGT

Downstream 100 bases:

>100_bases
CCTATGGCACTTTTAGACATTTGTAACCTCAATATTGAAATTCAAACCTCCAATGGACGTATAAAAATTGTAGATGGCGT
CAATCTTTCCCTTAACGAAG

Product: peptide ABC transporter permease

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MQNKEPDEFRESTSIFQIWLRFRQNTIALFSFYLLIALIFTALFASYLAPYADNRQFIGQELMPPSWVDRGKIAFFFGTD
DLGRDILSRLIMGTRYTLGSALLVVFSVAIIGGALGIIAGLLKGIKARFVGHIFDAFLSLPILLIAVVISTLMEPSLWNA
MFATLLAILPYFIHTIYRAIQKELEKDYVVMLKLEGISNQALLKSTILPNITVIYIQEVARAFVIAVLDISALSFISLGA
QRPTPEWGAMIKDSLELLYLAPWTVLLPGFAIIFTILLSIIFSNGLTKAINQHQE

Sequences:

>Translated_295_residues
MQNKEPDEFRESTSIFQIWLRFRQNTIALFSFYLLIALIFTALFASYLAPYADNRQFIGQELMPPSWVDRGKIAFFFGTD
DLGRDILSRLIMGTRYTLGSALLVVFSVAIIGGALGIIAGLLKGIKARFVGHIFDAFLSLPILLIAVVISTLMEPSLWNA
MFATLLAILPYFIHTIYRAIQKELEKDYVVMLKLEGISNQALLKSTILPNITVIYIQEVARAFVIAVLDISALSFISLGA
QRPTPEWGAMIKDSLELLYLAPWTVLLPGFAIIFTILLSIIFSNGLTKAINQHQE
>Mature_295_residues
MQNKEPDEFRESTSIFQIWLRFRQNTIALFSFYLLIALIFTALFASYLAPYADNRQFIGQELMPPSWVDRGKIAFFFGTD
DLGRDILSRLIMGTRYTLGSALLVVFSVAIIGGALGIIAGLLKGIKARFVGHIFDAFLSLPILLIAVVISTLMEPSLWNA
MFATLLAILPYFIHTIYRAIQKELEKDYVVMLKLEGISNQALLKSTILPNITVIYIQEVARAFVIAVLDISALSFISLGA
QRPTPEWGAMIKDSLELLYLAPWTVLLPGFAIIFTILLSIIFSNGLTKAINQHQE

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides

COG id: COG4171

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1787549, Length=284, Percent_Identity=42.9577464788732, Blast_Score=259, Evalue=1e-70,
Organism=Escherichia coli, GI1789964, Length=279, Percent_Identity=36.2007168458781, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1787054, Length=291, Percent_Identity=29.553264604811, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1787760, Length=269, Percent_Identity=28.996282527881, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789889, Length=222, Percent_Identity=24.7747747747748, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787498, Length=272, Percent_Identity=24.2647058823529, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788505, Length=192, Percent_Identity=22.3958333333333, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAPC_HAEIN (P45287)

Other databases:

- EMBL:   L42023
- PIR:   C64134
- RefSeq:   NP_439782.1
- GeneID:   950835
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1640
- NMPDR:   fig|71421.1.peg.1554
- TIGR:   HI_1640
- HOGENOM:   HBG729429
- OMA:   EPDEFRE
- ProtClustDB:   CLSK870295
- BioCyc:   HINF71421:HI_1640-MONOMER
- InterPro:   IPR000515

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 33015; Mature: 33015

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xece8d90)-; HASH(0xe911d84)-; HASH(0xeed3254)-; HASH(0xeecb9a0)-; HASH(0xe662228)-; HASH(0xe93bc7c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKEPDEFRESTSIFQIWLRFRQNTIALFSFYLLIALIFTALFASYLAPYADNRQFIGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ELMPPSWVDRGKIAFFFGTDDLGRDILSRLIMGTRYTLGSALLVVFSVAIIGGALGIIAG
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKGIKARFVGHIFDAFLSLPILLIAVVISTLMEPSLWNAMFATLLAILPYFIHTIYRAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKELEKDYVVMLKLEGISNQALLKSTILPNITVIYIQEVARAFVIAVLDISALSFISLGA
HHHHCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QRPTPEWGAMIKDSLELLYLAPWTVLLPGFAIIFTILLSIIFSNGLTKAINQHQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH
>Mature Secondary Structure
MQNKEPDEFRESTSIFQIWLRFRQNTIALFSFYLLIALIFTALFASYLAPYADNRQFIGQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ELMPPSWVDRGKIAFFFGTDDLGRDILSRLIMGTRYTLGSALLVVFSVAIIGGALGIIAG
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKGIKARFVGHIFDAFLSLPILLIAVVISTLMEPSLWNAMFATLLAILPYFIHTIYRAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKELEKDYVVMLKLEGISNQALLKSTILPNITVIYIQEVARAFVIAVLDISALSFISLGA
HHHHCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QRPTPEWGAMIKDSLELLYLAPWTVLLPGFAIIFTILLSIIFSNGLTKAINQHQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800