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The map label for this gene is alr

Identifier: 16273470

GI number: 16273470

Start: 1643226

End: 1644308

Strand: Direct

Name: alr

Synonym: HI1575

Alternate gene names: 16273470

Gene position: 1643226-1644308 (Clockwise)

Preceding gene: 16273469

Following gene: 161350019

Centisome position: 89.79

GC content: 40.54

Gene sequence:

>1083_bases
ATGAACGTAAAACCGGCGACAGCGAAAATTAGTTCGCACGCCTTAAAACAGAATTTAGAAATAATTAAACAAAAAGCACC
AAATAGCAAAATTATTGCTGTGGTTAAAGCAAACGCCTATGGTCACGGCGTTGTATTCGTTGCTTCAACCTTAGAACAAA
ATGTTGATTGCTTTGGCGTGGCGCGTTTAGAAGAGGCTTTAGCATTACGCTCCAACGGCATTACTAAACCGATTTTATTG
CTTGAAGGTTTTTTCAATGAACAAGATTTGCCTATTCTAGCCGTTAATAATATTGAAACCGTGGTACACAATCACGAACA
GCTTGATGCTTTAAAACGTGCGAATTTACCAAGTCCAATTAAGGTTTGGTTAAAAATAGATACGGGAATGCATCGCTTGG
GCGTTGCTCTTGATGAAGTGGATTATTTTTATCAAGAACTGAAAAAACTCCCTCAAATTCAACCGCACTTAGGCTTTGTC
AGCCATTTCAGCCGAGCCGATGAACTAGAATCAGATTACACCCAACTTCAAATCAATCGTTTTTTATCCGTCACAAAAGA
TAAACAAGGTGAACGTACTATTGCAGCGTCAGGCGGCATTCTTTTCTGGCCAAAATCCCACTTAGAATGTATCCGCCCAG
GCATTATTATGTACGGCATTTCTCCAACTGATACTATCGGTAAAGAGTTTGGCTTAACGCCAGTGATGAATTTAACCTCG
TCATTAATTGCCGTTCGCCATCATAAACAAGGCGATCCTGTAGGTTACGGCGGTATTTGGACAAGTCCACGAGATACCAA
AATTGGAGTGGTCGCAATGGGTTATGGCGATGGTTATCCGCGCGATGTGCCAGAAGGTACACCTGTTTATTTAAATGGCC
GTCTTGTACCAATTGTTGGACGTGTGTCAATGGATATGCTTACTGTTGATTTAGGCGCAGATAGCCAAGATTTGGTAGGC
GATGAAGTAATTTTATGGGGCAAGGAATTACCTATTGAAACCGTAGCTAAATTCACAGGCATTTTAAGCTACGAGCTAAT
TACAAAATTAACACCTCGTGTTATAACTGAATACGTTGATTAA

Upstream 100 bases:

>100_bases
CCCAATTGGTCGAGTGCGGTTAAAATTTAATGGACAATTTTCACGCTTCGACAATCTCGCCGAACAACGTGAATATCGAG
ATGATTATTAAGGAAAAATA

Downstream 100 bases:

>100_bases
TCACTGCATTTTTTGAACAGAGGGAGTCATTCTCCCTAATAAAAATTCCAGAAAGTGCGGTTAAAATTTCAATTATTTTT
AATGAAAGGAAATACCATGA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGVARLEEALALRSNGITKPILL
LEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPIKVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFV
SHFSRADELESDYTQLQINRFLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVGRVSMDMLTVDLGADSQDLVG
DEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD

Sequences:

>Translated_360_residues
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGVARLEEALALRSNGITKPILL
LEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPIKVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFV
SHFSRADELESDYTQLQINRFLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVGRVSMDMLTVDLGADSQDLVG
DEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD
>Mature_360_residues
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGVARLEEALALRSNGITKPILL
LEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPIKVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFV
SHFSRADELESDYTQLQINRFLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVGRVSMDMLTVDLGADSQDLVG
DEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=360, Percent_Identity=56.9444444444444, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1787439, Length=353, Percent_Identity=41.643059490085, Blast_Score=273, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_HAEIN (P45257)

Other databases:

- EMBL:   L42023
- PIR:   E64130
- RefSeq:   NP_439721.1
- ProteinModelPortal:   P45257
- SMR:   P45257
- GeneID:   950435
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1575
- NMPDR:   fig|71421.1.peg.1497
- TIGR:   HI_1575
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- BioCyc:   HINF71421:HI_1575-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39705; Mature: 39705

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 36-36 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEHHHCCCCEEEH
ARLEEALALRSNGITKPILLLEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPI
HHHHHHHHHHHCCCCCHHHEEECCCCCCCCCEEEECCHHHHHHCHHHHHHHHHCCCCCCE
KVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFVSHFSRADELESDYTQLQINR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
HHHHCCCCCCCEEEEECCCEEECCHHHHHHHCCCEEEEECCCCHHHHHHCCCCHHHHHHH
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVG
HHHHHHHCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEC
RVSMDMLTVDLGADSQDLVGDEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD
CCEEEEEEEECCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEHHHCCCCEEEH
ARLEEALALRSNGITKPILLLEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPI
HHHHHHHHHHHCCCCCHHHEEECCCCCCCCCEEEECCHHHHHHCHHHHHHHHHCCCCCCE
KVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFVSHFSRADELESDYTQLQINR
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
HHHHCCCCCCCEEEEECCCEEECCHHHHHHHCCCEEEEECCCCHHHHHHCCCCHHHHHHH
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVG
HHHHHHHCCCCCCCCCCCEECCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEC
RVSMDMLTVDLGADSQDLVGDEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD
CCEEEEEEEECCCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800