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The map label for this gene is pgi [H]

Identifier: 161350019

GI number: 161350019

Start: 1644405

End: 1646054

Strand: Direct

Name: pgi [H]

Synonym: HI1576

Alternate gene names: 161350019

Gene position: 1644405-1646054 (Clockwise)

Preceding gene: 16273470

Following gene: 16273473

Centisome position: 89.85

GC content: 36.91

Gene sequence:

>1650_bases
ATGAAAAATATTAACCCAACTCACACCCATGCGTGGAAATCTCTCGAAGCACATAAAGCTGAATTGTCAAACATCACCAT
CCAAGATTTATTTAAACAAGAAAAAAATCGTTTTGACGATTATTCTTTAACATTCAATAACCAAATTCTTATCGATTTTT
CCAAAAACAACATCAATCAAACAACCCTTTCACATCTTCGCCAACTTGCTCAAGAATGCGCGCTTGATAGCGCAAAAGAA
GCAATGTTTACCGGTGAAAAAATCAATCGTACAGAAAATCGTGCCGTACTACATACCGCACTACGCAATCGCACTAATAC
GCCAGTGCTTGTTGATGGCAAAGATGTTATGCCTGAAGTCAATGCTGTGCTAGCTAAAATGAAAGATTTCTGTCAGCGTA
TTATTTCTGGCGAATGGAAAGGCTATACAGGTAAAGCCATTACGGATGTTGTGAATATTGGTATTGGTGGCTCTGACTTA
GGCCCTTATATGGTAACCGAAGCACTTCGCCCGTATAAAAATCATCTAAATATGCACTTTGTTTCAAATGTCGATGGTAC
ACATATTGCGGAAACCTTAAAAAAAGTCAATCCAGAAACGACTCTTTTCTTAGTAGCATCGAAAACTTTTACAACTCAAG
AAACCATGACAAATGCTCAAAGTGCGCGTGATTGGTTACTAAAAGCAGCGAAAGATGAAAGTGCAGTTGCAAAACATTTT
GCAGCATTATCAACCAATGCTAAAGATGTAGAAAAATTTGGCATTGATACCAATAATATGTTTGAATTTTGGGATTGGGT
TGGCGGTCGTTACTCTTTATGGTCAGCTATTGGTCTTTCAATTGCACTATCAATTGGCTTTGAAAACTTTGAAGCGTTAT
TAAATGGTGCGCATGAAATGGATAAACATTTCCTCTCTACTCCAATCGAACAAAATATCCCAACCACTTTAGCATTAGTT
GGTTTATGGAATACCAATTTCCTTGGTGCGCAAACAGAAGCTATCTTACCTTATGATCAATATTTACATCGCTTCGCGGC
TTATTTTCAACAAGGTAATATGGAATCAAATGGTAAATATGTGGATCGTGATGGCAATGTCATTAAAAATTATCAAACTG
GCCCTATCATTTGGGGAGAACCTGGTACAAACGGACAACACGCGTTCTATCAATTAATTCACCAAGGCACTACTTTAATT
CCTTGTGATTTTATTGCGCCAGCCCAAAGACATAACCCATTGGCAGATCATCACAATAAATTGCTTTCTAACTTCTTCGC
ACAAACAGAAGCATTAGCATTCGGAAAAACAAAAGAGGAAGTCGAGGCTGAATTTGTAAAAGCGGGGAAATCTTTGGATG
ATGTGAAAAATATTGTTCCATTTAAAGTATTCACTGGTAATAAGCCAACTAATTCGATTCTCGTTCAAAAAATCACGCCA
TTTACTTTAGGGGCATTAATTGCGATGTATGAACACAAAATCTTCGTACAAGGTGTGATTTTTAATATCTTTAGCTTCGA
TCAATGGGGTGTAGAACTAGGCAAACAACTTGCAAACAGAATTCTTCCTGAATTAACAGATTCTGAAAAAGTAGCAAGTC
ATGACAGTTCAACTAATGGATTAATTAATCAATTTAAAGCATGGCGTTAA

Upstream 100 bases:

>100_bases
TTAATCACTGCATTTTTTGAACAGAGGGAGTCATTCTCCCTAATAAAAATTCCAGAAAGTGCGGTTAAAATTTCAATTAT
TTTTAATGAAAGGAAATACC

Downstream 100 bases:

>100_bases
TTATTTGGATTTGAATAATTCTAGAGCTGTCACAAATAACGACTAAAAACTCTATTTAGGTTAAGATAATCAAATGAGAG
AAAGTCGCTTAAGTCAATAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTHTHAWKSLEAHKAELSNITIQDLFKQEKNRFDDYSLTFNNQILIDFSKNNINQTTLSHLRQLAQECALDSAKE
AMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEVNAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHF
AALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEMDKHFLSTPIEQNIPTTLALV
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRDGNVIKNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQRHNPLADHHNKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNGLINQFKAWR

Sequences:

>Translated_549_residues
MKNINPTHTHAWKSLEAHKAELSNITIQDLFKQEKNRFDDYSLTFNNQILIDFSKNNINQTTLSHLRQLAQECALDSAKE
AMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEVNAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHF
AALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEMDKHFLSTPIEQNIPTTLALV
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRDGNVIKNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQRHNPLADHHNKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNGLINQFKAWR
>Mature_549_residues
MKNINPTHTHAWKSLEAHKAELSNITIQDLFKQEKNRFDDYSLTFNNQILIDFSKNNINQTTLSHLRQLAQECALDSAKE
AMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEVNAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHF
AALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEMDKHFLSTPIEQNIPTTLALV
GLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKYVDRDGNVIKNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLI
PCDFIAPAQRHNPLADHHNKLLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITP
FTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNGLINQFKAWR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=538, Percent_Identity=64.6840148698885, Blast_Score=734, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=538, Percent_Identity=60.4089219330855, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=77.0491803278689, Blast_Score=905, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=519, Percent_Identity=63.776493256262, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=519, Percent_Identity=63.776493256262, Blast_Score=693, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=550, Percent_Identity=58.7272727272727, Blast_Score=647, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=541, Percent_Identity=65.9889094269871, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=541, Percent_Identity=65.9889094269871, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=541, Percent_Identity=65.9889094269871, Blast_Score=731, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61622; Mature: 61622

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTHTHAWKSLEAHKAELSNITIQDLFKQEKNRFDDYSLTFNNQILIDFSKNNINQ
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCH
TTLSHLRQLAQECALDSAKEAMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEV
HHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHH
NAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEM
HHHCCCHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHH
DKHFLSTPIEQNIPTTLALVGLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKY
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRDGNVIKNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLIPCDFIAPAQRHNPLADHHNK
ECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCHHHHHHH
LLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCCCEEEECCCH
FTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHH
LINQFKAWR
HHHHHHCCC
>Mature Secondary Structure
MKNINPTHTHAWKSLEAHKAELSNITIQDLFKQEKNRFDDYSLTFNNQILIDFSKNNINQ
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCH
TTLSHLRQLAQECALDSAKEAMFTGEKINRTENRAVLHTALRNRTNTPVLVDGKDVMPEV
HHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHH
NAVLAKMKDFCQRIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETLKKVNPETTLFLVASKTFTTQETMTNAQSARDWLLKAAKDESAVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AALSTNAKDVEKFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSIGFENFEALLNGAHEM
HHHCCCHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHH
DKHFLSTPIEQNIPTTLALVGLWNTNFLGAQTEAILPYDQYLHRFAAYFQQGNMESNGKY
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRDGNVIKNYQTGPIIWGEPGTNGQHAFYQLIHQGTTLIPCDFIAPAQRHNPLADHHNK
ECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCHHHHHHH
LLSNFFAQTEALAFGKTKEEVEAEFVKAGKSLDDVKNIVPFKVFTGNKPTNSILVQKITP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEEECCCCCCCEEEECCCH
FTLGALIAMYEHKIFVQGVIFNIFSFDQWGVELGKQLANRILPELTDSEKVASHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHH
LINQFKAWR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA