Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 16273346

GI number: 16273346

Start: 1527362

End: 1529239

Strand: Direct

Name: dxs [H]

Synonym: HI1439

Alternate gene names: 16273346

Gene position: 1527362-1529239 (Clockwise)

Preceding gene: 16273345

Following gene: 16273351

Centisome position: 83.46

GC content: 39.03

Gene sequence:

>1878_bases
ATGACTAACAATATGAACAATTATCCTCTTTTATCTTTAATTAATTCTCCAGAAGATTTGCGTCTTTTAAATAAAGATCA
GCTACCACAACTCTGTCAAGAATTACGTGCTTATCTTTTAGAATCTGTTAGTCAAACTAGCGGACATTTAGCGTCAGGTT
TAGGCACTGTAGAGCTAACCGTTGCGCTGCATTATGTATATAAGACGCCATTTGATCAGTTAATTTGGGATGTGGGACAT
CAAGCTTATCCACATAAAATCCTAACGGGTCGCCGAGAGCAAATGTCCACAATTCGCCAAAAAGACGGTATTCATCCTTT
TCCTTGGCGTGAAGAAAGTGAATTTGATGTATTAAGTGTTGGTCACTCCTCTACGTCTATTAGTGCGGGATTAGGCATTG
CCGTTGCCGCAGAACGAGAAAATGCAGGTAGAAAAACAGTATGCGTAATCGGTGATGGCGCAATTACTGCGGGAATGGCA
TTTGAGGCATTAAATCACGCGGGGGCATTGCATACAGATATGTTAGTTATTTTAAATGATAACGAAATGTCTATTTCAGA
AAACGTTGGTGCATTAAATAATCATCTTGCGCGTATTTTCTCTGGCTCTCTTTACTCTACGCTTCGTGATGGCAGTAAAA
AAATCCTTGATAAAGTTCCTCCAATCAAAAATTTTATGAAAAAAACCGAAGAACATATGAAAGGTGTAATGTTTTCGCCA
GAAAGTACATTATTTGAAGAACTCGGTTTTAACTATATTGGCCCAGTGGATGGGCATAACATTGATGAATTAGTGGCTAC
GCTTACGAATATGCGTAATCTGAAAGGCCCACAATTTTTGCATATAAAAACGAAAAAAGGTAAAGGATACGCACCCGCAG
AAAAAGATCCGATTGGTTTCCACGGTGTACCTAAATTTGATCCAATCAGTGGCGAATTGCCCAAAAACAATAGTAAACCA
ACTTATTCGAAAATTTTTGGCGATTGGCTATGTGAAATGGCAGAAAAAGATGCCAAAATTATAGGTATCACACCTGCAAT
GCGTGAGGGTTCAGGTATGGTAGAATTTTCCCAACGCTTCCCAAAACAATATTTTGACGTAGCGATTGCAGAACAGCACG
CTGTCACGTTTGCCACAGGACTTGCAATTGGCGGATATAAACCTGTCGTCGCAATTTACTCGACATTTTTACAACGTGCT
TACGATCAATTAATTCACGATGTTGCCATTCAAAATCTCCCTGTGCTATTTGCAATTGATCGAGCAGGGATAGTTGGTGC
AGATGGGGCTACACATCAAGGTGCATTCGATATTAGCTTTATGCGTTGCATTCCAAATATGATCATTATGACGCCGAGTG
ATGAAAATGAATGCCGTCAAATGCTCTATACAGGTTATCAATGTGGAAAACCTGCGGCAGTGCGCTACCCTCGCGGAAAT
GCCGTTGGTGTAAAACTTACTCCTTTAGAAATGCTTCCTATTGGTAAATCACGTTTAATTCGAAAAGGTCAAAAAATTGC
GATTTTAAATTTTGGTACTCTATTACCATCCGCTTTAGAGTTATCAGAAAAACTCAATGCAACGGTTGTCGATATGCGTT
TTGTGAAACCGATTGATATTGAAATGATTAATGTGCTTGCACAAACTCACGATTATTTGGTCACATTGGAAGAAAATGCA
ATTCAAGGTGGAGCGGGATCTGCTGTTGCGGAAGTACTAAATTCATCAGGAAAATCAACCGCACTTTTACAACTTGGCTT
GCCAGATTATTTTATTCCACAAGCGACACAGCAAGAAGCATTGGCAGATTTAGGATTGGATACAAAAGGCATTGAAGAAA
AAATTCTCAACTTTATTGCAAAACAAGGTAATTTATAA

Upstream 100 bases:

>100_bases
TTCCTTTTGATACAACCGTTCGTGCATTAGCTGAATTCATTATTACCAGAAAAAGTTAAATACCCACAAAAGTGCGGTCA
AAATTTATCACGTTTTTAAA

Downstream 100 bases:

>100_bases
AAATAAACGCGATGATAATTTCATCGCGTTTTTTCTTAATCCACAATTCTTAAATGGGAAACTGATTTTGTTTTCTTTTT
TTCTTCTCGTTTTTTAGGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MTNNMNNYPLLSLINSPEDLRLLNKDQLPQLCQELRAYLLESVSQTSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGH
QAYPHKILTGRREQMSTIRQKDGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAERENAGRKTVCVIGDGAITAGMA
FEALNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSLYSTLRDGSKKILDKVPPIKNFMKKTEEHMKGVMFSP
ESTLFEELGFNYIGPVDGHNIDELVATLTNMRNLKGPQFLHIKTKKGKGYAPAEKDPIGFHGVPKFDPISGELPKNNSKP
TYSKIFGDWLCEMAEKDAKIIGITPAMREGSGMVEFSQRFPKQYFDVAIAEQHAVTFATGLAIGGYKPVVAIYSTFLQRA
YDQLIHDVAIQNLPVLFAIDRAGIVGADGATHQGAFDISFMRCIPNMIIMTPSDENECRQMLYTGYQCGKPAAVRYPRGN
AVGVKLTPLEMLPIGKSRLIRKGQKIAILNFGTLLPSALELSEKLNATVVDMRFVKPIDIEMINVLAQTHDYLVTLEENA
IQGGAGSAVAEVLNSSGKSTALLQLGLPDYFIPQATQQEALADLGLDTKGIEEKILNFIAKQGNL

Sequences:

>Translated_625_residues
MTNNMNNYPLLSLINSPEDLRLLNKDQLPQLCQELRAYLLESVSQTSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGH
QAYPHKILTGRREQMSTIRQKDGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAERENAGRKTVCVIGDGAITAGMA
FEALNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSLYSTLRDGSKKILDKVPPIKNFMKKTEEHMKGVMFSP
ESTLFEELGFNYIGPVDGHNIDELVATLTNMRNLKGPQFLHIKTKKGKGYAPAEKDPIGFHGVPKFDPISGELPKNNSKP
TYSKIFGDWLCEMAEKDAKIIGITPAMREGSGMVEFSQRFPKQYFDVAIAEQHAVTFATGLAIGGYKPVVAIYSTFLQRA
YDQLIHDVAIQNLPVLFAIDRAGIVGADGATHQGAFDISFMRCIPNMIIMTPSDENECRQMLYTGYQCGKPAAVRYPRGN
AVGVKLTPLEMLPIGKSRLIRKGQKIAILNFGTLLPSALELSEKLNATVVDMRFVKPIDIEMINVLAQTHDYLVTLEENA
IQGGAGSAVAEVLNSSGKSTALLQLGLPDYFIPQATQQEALADLGLDTKGIEEKILNFIAKQGNL
>Mature_624_residues
TNNMNNYPLLSLINSPEDLRLLNKDQLPQLCQELRAYLLESVSQTSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGHQ
AYPHKILTGRREQMSTIRQKDGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAERENAGRKTVCVIGDGAITAGMAF
EALNHAGALHTDMLVILNDNEMSISENVGALNNHLARIFSGSLYSTLRDGSKKILDKVPPIKNFMKKTEEHMKGVMFSPE
STLFEELGFNYIGPVDGHNIDELVATLTNMRNLKGPQFLHIKTKKGKGYAPAEKDPIGFHGVPKFDPISGELPKNNSKPT
YSKIFGDWLCEMAEKDAKIIGITPAMREGSGMVEFSQRFPKQYFDVAIAEQHAVTFATGLAIGGYKPVVAIYSTFLQRAY
DQLIHDVAIQNLPVLFAIDRAGIVGADGATHQGAFDISFMRCIPNMIIMTPSDENECRQMLYTGYQCGKPAAVRYPRGNA
VGVKLTPLEMLPIGKSRLIRKGQKIAILNFGTLLPSALELSEKLNATVVDMRFVKPIDIEMINVLAQTHDYLVTLEENAI
QGGAGSAVAEVLNSSGKSTALLQLGLPDYFIPQATQQEALADLGLDTKGIEEKILNFIAKQGNL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=581, Percent_Identity=21.8588640275387, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4507521, Length=581, Percent_Identity=21.8588640275387, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637459, Length=418, Percent_Identity=24.4019138755981, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI225637463, Length=418, Percent_Identity=24.4019138755981, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI225637461, Length=418, Percent_Identity=24.4019138755981, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI133778974, Length=544, Percent_Identity=21.6911764705882, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156564403, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786622, Length=622, Percent_Identity=72.6688102893891, Blast_Score=952, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=584, Percent_Identity=23.972602739726, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666278, Length=619, Percent_Identity=24.232633279483, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551847, Length=627, Percent_Identity=23.9234449760766, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550715, Length=627, Percent_Identity=23.9234449760766, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645119, Length=528, Percent_Identity=24.2424242424242, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21358145, Length=231, Percent_Identity=25.1082251082251, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650940, Length=231, Percent_Identity=25.1082251082251, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68504; Mature: 68372

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNMNNYPLLSLINSPEDLRLLNKDQLPQLCQELRAYLLESVSQTSGHLASGLGTVELT
CCCCCCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEE
VALHYVYKTPFDQLIWDVGHQAYPHKILTGRREQMSTIRQKDGIHPFPWREESEFDVLSV
HEEHHHHHCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGIAVAAERENAGRKTVCVIGDGAITAGMAFEALNHAGALHTDMLVILND
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLARIFSGSLYSTLRDGSKKILDKVPPIKNFMKKTEEHMKGVMFSP
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECC
ESTLFEELGFNYIGPVDGHNIDELVATLTNMRNLKGPQFLHIKTKKGKGYAPAEKDPIGF
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
HGVPKFDPISGELPKNNSKPTYSKIFGDWLCEMAEKDAKIIGITPAMREGSGMVEFSQRF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHC
PKQYFDVAIAEQHAVTFATGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAID
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGIVGADGATHQGAFDISFMRCIPNMIIMTPSDENECRQMLYTGYQCGKPAAVRYPRGN
CCCEEECCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCC
AVGVKLTPLEMLPIGKSRLIRKGQKIAILNFGTLLPSALELSEKLNATVVDMRFVKPIDI
EEEEEECCCEECCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHH
EMINVLAQTHDYLVTLEENAIQGGAGSAVAEVLNSSGKSTALLQLGLPDYFIPQATQQEA
HHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHH
LADLGLDTKGIEEKILNFIAKQGNL
HHHCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNNMNNYPLLSLINSPEDLRLLNKDQLPQLCQELRAYLLESVSQTSGHLASGLGTVELT
CCCCCCCCEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEE
VALHYVYKTPFDQLIWDVGHQAYPHKILTGRREQMSTIRQKDGIHPFPWREESEFDVLSV
HEEHHHHHCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGIAVAAERENAGRKTVCVIGDGAITAGMAFEALNHAGALHTDMLVILND
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLARIFSGSLYSTLRDGSKKILDKVPPIKNFMKKTEEHMKGVMFSP
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECC
ESTLFEELGFNYIGPVDGHNIDELVATLTNMRNLKGPQFLHIKTKKGKGYAPAEKDPIGF
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
HGVPKFDPISGELPKNNSKPTYSKIFGDWLCEMAEKDAKIIGITPAMREGSGMVEFSQRF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHC
PKQYFDVAIAEQHAVTFATGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQNLPVLFAID
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGIVGADGATHQGAFDISFMRCIPNMIIMTPSDENECRQMLYTGYQCGKPAAVRYPRGN
CCCEEECCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCC
AVGVKLTPLEMLPIGKSRLIRKGQKIAILNFGTLLPSALELSEKLNATVVDMRFVKPIDI
EEEEEECCCEECCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHH
EMINVLAQTHDYLVTLEENAIQGGAGSAVAEVLNSSGKSTALLQLGLPDYFIPQATQQEA
HHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHH
LADLGLDTKGIEEKILNFIAKQGNL
HHHCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA