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The map label for this gene is purM [H]

Identifier: 16273334

GI number: 16273334

Start: 1517222

End: 1518256

Strand: Reverse

Name: purM [H]

Synonym: HI1429

Alternate gene names: 16273334

Gene position: 1518256-1517222 (Counterclockwise)

Preceding gene: 16273338

Following gene: 16273333

Centisome position: 82.96

GC content: 44.44

Gene sequence:

>1035_bases
GTGAGCAACACACAACTGAGCTATAAAGATGCTGGCGTCGATATTCACACTGGAAATGAATTAGTCGAACGTATCAAAGG
CGATGTAAAACGCACTCGCCGCTCTGAAGTTATGGGCGGATTGGGTGGTTTCGGCGCATTATGTGCTTTACCCACCAAAT
ATAAAGAGCCAATTTTAGTTTCTGGTACAGATGGCGTTGGCACAAAATTACGACTTGCGATTGACTTGAAAAAACACGAT
ACCATCGGTCAAGATTTAGTGGCAATGTGTGTAAACGACTTAATCGTACAAGGGGCAGAACCGCTTTTCTTCTTAGATTA
CTATGCTACAGGGAAATTAGACGTTGATGTGGCAGCAAGTGTGATCAAAGGTATTGCAGATGGTTGTGAAATGTCTGGCT
GTGCGTTAGTGGGTGGCGAAACCGCCGAAATGCCAGGAATGTATCACGAAGGGGACTATGATTTGGCGGGTTTCTGCGTA
GGCGTGGTTGAAAAATCAGAGATTATTGACGGCACAGCAGTGAAAACAGGCGACACGCTTATCGCACTCGGCTCAAGCGG
TGCACACTCAAACGGTTATTCGTTAATTCGCAAAGTGCTTGAAGTAAGTGGTGCAAATCCAACGGATTTATTAGAAGGCA
AACCGCTTAGCGAGCATCTTTTAGCCCCAACCAAAATCTATGTAAAATCGATTTTACAGTTGATCAAGCAGACCGAAGTT
CACGCCATTGCTCACTTAACAGGTGGTGGTTTCTGGGAAAATATCCCGCGTGTATTACCTGACAATACTAAAGCAGTGAT
TGATGAATCAAGCTGGCAATGGCCTGCGATCTTCAACTGGTTACAAGAAAAAGGCAATATCAGCCGTTATGAAATGTATC
GCACCTTTAACTGTGGCGTAGGTATGGTAATTGCATTACCAGAAAAAGAGGTTGAAACCGCTCTTGCATTGCTTGAACAA
TCGGGCGAAAAAGCGTGGGTTATCGGCAAAATTGAACATCTTGGCGAAAGCGAGGCACAGGTTGAGATTCAATAA

Upstream 100 bases:

>100_bases
TTTTAAAAATGTCATTAAATGAATTAATTTAACAATATCGCAAACGTTTGCTTGATGATATAATCTGCCCAATTTTTATT
TCAATTGATCGAGGTTAATC

Downstream 100 bases:

>100_bases
TAAAATCTTAAATTTAAATTCAGCCCTTTTGGGCTGATTTCTATAAGGAAGAAAATGAAAAAAATTGCCGTCCTTATTTC
TGGTCAAGGAACAAATTTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLKKHD
TIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAASVIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCV
GVVEKSEIIDGTAVKTGDTLIALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEV
HAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGVGMVIALPEKEVETALALLEQ
SGEKAWVIGKIEHLGESEAQVEIQ

Sequences:

>Translated_344_residues
MSNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLKKHD
TIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAASVIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCV
GVVEKSEIIDGTAVKTGDTLIALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEV
HAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGVGMVIALPEKEVETALALLEQ
SGEKAWVIGKIEHLGESEAQVEIQ
>Mature_343_residues
SNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLKKHDT
IGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAASVIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCVG
VVEKSEIIDGTAVKTGDTLIALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEVH
AIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGVGMVIALPEKEVETALALLEQS
GEKAWVIGKIEHLGESEAQVEIQ

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=49.1329479768786, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=49.1329479768786, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=49.1329479768786, Blast_Score=338, Evalue=5e-93,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=77.1929824561403, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=41.6909620991254, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=46.9026548672566, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24582400, Length=290, Percent_Identity=43.1034482758621, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37067; Mature: 36936

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILV
CCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLKKHDTIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAS
ECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHH
VIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCVGVVEKSEIIDGTAVKTGDTL
HHHHHHCCCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEE
IALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEV
EEECCCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
HAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGV
HEEEEECCCCHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCC
GMVIALPEKEVETALALLEQSGEKAWVIGKIEHLGESEAQVEIQ
EEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEEC
>Mature Secondary Structure 
SNTQLSYKDAGVDIHTGNELVERIKGDVKRTRRSEVMGGLGGFGALCALPTKYKEPILV
CCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLKKHDTIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAS
ECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHH
VIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCVGVVEKSEIIDGTAVKTGDTL
HHHHHHCCCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEE
IALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEV
EEECCCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
HAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGV
HEEEEECCCCHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCC
GMVIALPEKEVETALALLEQSGEKAWVIGKIEHLGESEAQVEIQ
EEEEECCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA