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The map label for this gene is pyrD [H]

Identifier: 16273310

GI number: 16273310

Start: 1497588

End: 1498607

Strand: Reverse

Name: pyrD [H]

Synonym: HI1401

Alternate gene names: 16273310

Gene position: 1498607-1497588 (Counterclockwise)

Preceding gene: 30995447

Following gene: 16273309

Centisome position: 81.88

GC content: 37.84

Gene sequence:

>1020_bases
ATGTATCAATTATTCCGTCACGGCATTTTCCAAATGGATGCTGAAAAGGCTCATAATTTCACGATTCAATGCTTGAAATT
AGCTGGTAATCCTTTATTTCAACCGATCTTAAAATCTCTTATTCATGCTCCCAAAGGCTTTCCGAAAACGGTAATGGGTG
TGAATTTCCCTAATCCCATTGGATTGGCGGCAGGAGCGGATAAAAATGGCGATGCGATTGACGGCTTTGGTGCATTGGGT
TTTGGTTTTTTAGAACTGGGAACTGTCACGCCCGTTGCACAAGATGGGAATGCAAAGCCACGTCAGTTTCGTTTGATTGA
AGCTGAAGGCATTATTAACCGTAATGGTTTTAATAATAATGGTATTGACTATCTTATAGAAAATGTGAAAAACGCCCGTT
ATAAAGGTGTGATAGGCATCAATATTGGTAAGAATAAATTTACATCTTTGGAACAAGGCAAAGATGATTATATTTTCTGT
TTGAACAAAGCCTATAACTACGCAGGTTATATTACGGTGAATATTTCATCTCCCAATACACCAGATTTGCGTCAATTACA
ATATGGTGATTATTTCGATGATTTATTGCGAAGCATTAAGGATCGTCAGGCTATTTTGGCAAACCAATACAATAAATATG
TGCCGATTGCGGTAAAAATTGCACCAGATTTAACGGAAAGTGAATTAGTGCAAATTGCGGATACATTGGTTCGTCATAAA
ATGGATGGCGTTATTGCAACGAATACTACAATTTCTCGTGATACGGTTACGGGGATGAAAAATGCCGAACAGCAAGGCGG
ATTAAGTGGAAAGCCGTTGCAGCATAAAAGCACGGAGATTATTAAGCGATTACATCAAGAACTGAAAGGTCAGATTCCCA
TTATTGGTAGCGGTGGCATTGATGGGTTGCAAAATGCACAAGAGAAAATTGAGGCTGGTGCAGAGTTGTTGCAAGTTTAT
TCAGGATTGATTTATCACGGTCCAAAATTAGTAAAAGAATTAGTAAAAAATATTAAATAA

Upstream 100 bases:

>100_bases
CATTTTTGTTCCTCGTAGAATACGACCAACCTTACCTTTAAAGTGCGGTGAAAATTGACCGCACTTTCTTACAGTAAACT
ATCCCGAGAGATAAACGAGT

Downstream 100 bases:

>100_bases
TGACAAAAAAATACGACTTACATTGTCATAGTACCGCATCAGATGGAGTGTTGAGTCCAACCGAATTAGTGCATCGTGCT
TATGCGCAAGGCGTGAACGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MYQLFRHGIFQMDAEKAHNFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK

Sequences:

>Translated_339_residues
MYQLFRHGIFQMDAEKAHNFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK
>Mature_339_residues
MYQLFRHGIFQMDAEKAHNFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=338, Percent_Identity=37.8698224852071, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=60.6508875739645, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17509475, Length=344, Percent_Identity=39.8255813953488, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI281361352, Length=342, Percent_Identity=41.2280701754386, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17137316, Length=342, Percent_Identity=41.2280701754386, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37271; Mature: 37271

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQLFRHGIFQMDAEKAHNFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPI
CCCHHHCCHHHCCHHHHCCHHEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCC
GLAAGADKNGDAIDGFGALGFGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCC
GIDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFCLNKAYNYAGYITVNISSPNT
CHHHHHHHHCCCCCCEEEEEECCCCHHCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCC
PDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
MDGVIATNTTISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGI
HCCEEEECCEECHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
DGLQNAQEKIEAGAELLQVYSGLIYHGPKLVKELVKNIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MYQLFRHGIFQMDAEKAHNFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPI
CCCHHHCCHHHCCHHHHCCHHEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCC
GLAAGADKNGDAIDGFGALGFGFLELGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCC
GIDYLIENVKNARYKGVIGINIGKNKFTSLEQGKDDYIFCLNKAYNYAGYITVNISSPNT
CHHHHHHHHCCCCCCEEEEEECCCCHHCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCC
PDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
MDGVIATNTTISRDTVTGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGI
HCCEEEECCEECHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
DGLQNAQEKIEAGAELLQVYSGLIYHGPKLVKELVKNIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA