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The map label for this gene is tyrA

Identifier: 16273204

GI number: 16273204

Start: 1371056

End: 1372189

Strand: Direct

Name: tyrA

Synonym: HI1290

Alternate gene names: 16273204

Gene position: 1371056-1372189 (Clockwise)

Preceding gene: 16273203

Following gene: 16273210

Centisome position: 74.92

GC content: 38.45

Gene sequence:

>1134_bases
GTGAGTTTTATGGAAGCCCTTAAAGATTTACGTTCTGAAATTGATTCGCTTGATCGCGAACTTATCCAACTTTTTGCTAA
ACGTCTTGAGTTGGTTTCTCAAGTCGGTAAAGTGAAACATCAACATGGATTACCTATTTATGCGCCAGAACGTGAAATAG
CAATGCTCCAAGCACGTCGTTTAGAAGCTGAAAAAGCAGGCATTTCAGCCGATTTAATTGAAGATGTTCTACGCCGTTTT
ATGCGTGAATCCTATGCCAATGAAAACCAATTTGGTTTTAAAACTATCAATTCTGATATTCACAAAATTGTTATTGTGGG
CGGTTATGGTAAATTAGGCGGCTTATTTGCCCGTTATTTACGTGCATCTGGCTATCCAATTTCTATTTTAGATCGCGAAG
ATTGGGCGGTGGCTGAAAGTATTTTAGCGAATGCTGATGTCGTGATCGTTTCCGTCCCTATTAATCTCACCTTAGAAACA
ATTGAACGCTTAAAACCTTATTTAACGGAAAACATGCTACTTGCAGATTTAACCTCTGTTAAGCGTGAACCGCTAGCGAA
AATGCTTGAAGTTCATACTGGTGCTGTTTTAGGTTTACATCCAATGTTTGGTGCAGATATTGCAAGTATGGCAAAACAAG
TGGTTGTGCGTTGTGATGGACGTTTTCCTGAACGTTATGAATGGTTACTTGAGCAAATTCAAATTTGGGGTGCAAAAATT
TATCAAACCAATGCCACAGAACACGATCATAATATGACTTATATACAAGCCTTGCGCCATTTTTCGACTTTTGCGAATGG
TTTACACCTTTCCAAACAGCCCATTAATCTCGCTAATTTATTGGCACTTTCTTCCCCTATTTATCGGTTAGAACTTGCGA
TGATAGGTCGTTTATTTGCGCAAGATGCAGAGCTTTACGCAGATATTATTATGGATAAGTCAGAAAATTTAGCGGTAATT
GAAACGCTAAAACAAACTTACGACGAAGCCTTAACTTTCTTTGAAAATAATGATCGTCAAGGTTTTATTGATGCTTTCCA
CAAGGTGCGTGACTGGTTTGGCGATTATTCCGAACAATTTTTAAAAGAAAGCCGTCAGCTATTGCAACAGGCAAATGATT
TGAAACAAGGGTAG

Upstream 100 bases:

>100_bases
TTAATTACACAATCCGCATAACTTCATTGCCTTTCCTGTAAAATTCTAGTAATCTCCTTGTAATTAATTTTTTACAATAT
ATGTAAGATAAAAATTACAG

Downstream 100 bases:

>100_bases
AGAAAAGTGCGGTGAAATTTCACCGCAGTTTTTTACTGTCTCGCTAATCTTAAATTTTCAGGTAAATTCTCAAAATTAGA
GCGGAATGGATTAATGTCTA

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSFMEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRF
MRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINLTLET
IERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKI
YQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKSENLAVI
ETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG

Sequences:

>Translated_377_residues
MSFMEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRF
MRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINLTLET
IERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKI
YQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKSENLAVI
ETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG
>Mature_376_residues
SFMEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRFM
RESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINLTLETI
ERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIY
QTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKSENLAVIE
TLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain

Homologues:

Organism=Escherichia coli, GI1788952, Length=370, Percent_Identity=58.1081081081081, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TYRA_HAEIN (P43902)

Other databases:

- EMBL:   L42023
- PIR:   H64114
- RefSeq:   NP_439442.1
- PDB:   2PV7
- PDBsum:   2PV7
- ProteinModelPortal:   P43902
- SMR:   P43902
- GeneID:   950220
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1290
- NMPDR:   fig|71421.1.peg.1230
- TIGR:   HI_1290
- HOGENOM:   HBG538602
- OMA:   HGLPIYA
- ProtClustDB:   PRK11199
- BioCyc:   HINF71421:HI_1290-MONOMER
- BRENDA:   1.3.1.12
- BRENDA:   5.4.99.5
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099
- Gene3D:   G3DSA:1.20.59.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF001499
- SMART:   SM00830
- TIGRFAMs:   TIGR01799

Pfam domain/function: PF01817 CM_2; PF02153 PDH; SSF48179 6DGDH_C_like; SSF48600 Chorismate_mut

EC number: =5.4.99.5; =1.3.1.12

Molecular weight: Translated: 43023; Mature: 42892

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS51168 CHORISMATE_MUT_2; PS51176 PDH_ADH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFMEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LEAEKAGISADLIEDVLRRFMRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHH
RASGYPISILDREDWAVAESILANADVVIVSVPINLTLETIERLKPYLTENMLLADLTSV
HCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
KREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKI
HHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHE
YQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFA
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
QDAELYADIIMDKSENLAVIETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKESRQLLQQANDLKQG
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFMEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LEAEKAGISADLIEDVLRRFMRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHH
RASGYPISILDREDWAVAESILANADVVIVSVPINLTLETIERLKPYLTENMLLADLTSV
HCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
KREPLAKMLEVHTGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKI
HHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHE
YQTNATEHDHNMTYIQALRHFSTFANGLHLSKQPINLANLLALSSPIYRLELAMIGRLFA
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
QDAELYADIIMDKSENLAVIETLKQTYDEALTFFENNDRQGFIDAFHKVRDWFGDYSEQF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKESRQLLQQANDLKQG
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800